3-Amide-4-phenylcoumarin and preparation method thereof

CN110294729AInactive Publication Date: 2019-10-01LIAONING UNIVERSITY OF PETROLEUM AND CHEMICAL TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
LIAONING UNIVERSITY OF PETROLEUM AND CHEMICAL TECHNOLOGY
Publication Date
2019-10-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of 3-amide-4-phenylcoumarin. Phenylpropiolic acid ester, oxamide, potassium persulfate, silver nitrate, natrium aceticum and a solvent are added into a reaction container in sequence for standby use; nitrogen is introduced into the reaction container, so that the inside of the reactioncontainer is in a nitrogen atmosphere; the reaction container is placed in an environment at 60-120 DEG C, a reaction is conducted at the stirring speed of 500-1,000 r / min, in the reaction process, the concentration of the phenylpropiolic acid ester in reaction liquid is monitored, and after it is monitored that the phenylpropiolic acid ester reacts completely, the reaction is finished; the reaction liquid is filtered and concentrated, and the 3-amide-4-phenylcoumarin is obtained. According to the synthesis method, under the mild condition, the 3-amide-4-phenylcoumarin is efficiently prepared, the cleanliness of the synthesis reaction is improved, the environmental pollution is reduced, and the adopted raw materials are single in type; the cost is reduced, and the economical efficiency ofthe technology is improved.
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Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a synthesis method of 3-amide-4-phenylcoumarin. Background technique

[0002] In the industrial synthesis of coumarin, the intermediate o-cresol phosphate is obtained through the action of o-cresol and phosphorus oxychloride, and chlorinated at 180 ° C to change the methyl group into -CHCl 2 , and then react with sodium acetate at 160-180°C for 5 hours for cyclization.

[0003] With the development of environmental economy, the disadvantages of unsustainable development, high cost, and highly toxic raw materials exposed by traditional production methods urgently need to be replaced by more environmentally friendly and low-cost methods. Contents of the invention

[0004] The invention provides a method for synthesizing novel coumarin derivatives 3-amide-4-phenylcoumarin under mild conditions, which solves the problem that the traditional production method ...

Claims

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