Molecular markers INHBA and SPP1 and application thereof

A technology of molecular markers and markers, applied in the direction of recombinant DNA technology, biochemical equipment and methods, DNA/RNA fragments, etc., can solve the problem of inability to better meet clinical needs, incomplete clarity of molecular markers for lymph node metastasis, etc. problem, to achieve high accuracy, high repeatability, and small sample size
CN110295230APending Publication Date: 2019-10-01SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SUN YAT SEN UNIV
Publication Date
2019-10-01

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Abstract

The invention discloses a set of markers used for early gastric cancer diagnosis. The markers are composed of INHBA and SPP1. The invention also discloses application of the INHBA and the SPP1 in preparing a kit for early gastric cancer diagnosis and a kit for predicting lymphatic metastasis status of a gastric cancer patient. The expression quantities of the INHBA and SPP1 are detected by adopting a semi-quantitative fluorescence real-time enzyme-linked reaction method, and compared with traditional pathological cytology detection, the detection of molecular markers has the advantages of small required sample size, specificity, sensitivity, accuracy, high repeatability, automation and the like. The molecular markers lay an ideal clinical application basis for the early gastric cancer diagnosis and the prediction of the lymphatic metastasis.
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Description

technical field

[0001] The invention relates to the technical field of gastric cancer detection, in particular to molecular markers INHBA and SPP1 and applications thereof. Background technique

[0002] Gastric cancer is one of the most common malignant tumors in China. Gastric cancer in my country has the characteristics of high morbidity and mortality, low proportion of early gastric cancer, and advanced and metastatic gastric cancer cases. In recent years, with the rapid development of molecular biology technology, the application of molecular markers for tumor screening, diagnosis and prognosis has attracted more and more attention. However, there is no effective molecular marker with high sensitivity and specificity. features. Introducing a non-invasive or minimally invasive, objective, efficient, specific and sensitive new detection method for asymptomatic and high-risk groups is crucial to improving the diagnostic rate of early gastric cancer. At the same time, it ...

Claims

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