Hydrogel vascular micro stent and preparation method thereof

Abstract

The invention provides a hydrogel vascular micro stent and a preparation method thereof. The preparation method comprises the following steps that (a), 3D printing of a mixed solution of GelMA hydrogel and photoinitiator is carried out to obtain GelMA hydrogel tablet; and (b), the GelMA hydrogel tablet obtained from step (a) is self-coiled in imitation of apple peel to obtain the hydrogel vascularmicro stent. Compared with the prior art, the preparation method, different from the previous 3D printing, constructs the hydrogel vascular micro stent in the self-crimping way by imitating the applepeel and can construct a more fine micro-hollow tube (less than 200 [mu]m),the hydrogel vascular micro stent can first construct gel sheets of different shapes and sizes, and then obtain gel tubes ofcorresponding forms with a higher accuracy and controllability; and moreover, the hydrogel vascular micro stent obtained by the preparation method has good cell affinity, good biocompatibility and rich forms, the bionic need of all forms of vascular stents can be basically met, and great development prospects can be reached.

Description

technical field [0001] The invention relates to the technical field of microvascular stents, in particular to a hydrogel vascular microstent and a preparation method thereof. Background technique [0002] The complex vascular network is crucial to the survival and repair of tissues. Through the large blood vessels to the micro vascular network, blood continuously circulates and transports nutrients and metabolites; otherwise, it will lead to some difficult problems such as skin flap necrosis, coronary heart disease, and osteonecrosis . During the process of vascularization, various angiogenic cells such as endothelial cells migrate to form primary capillaries, which further develop into arterioles and venules. Based on this, many studies are dedicated to improving tissue blood supply, accelerating tissue regeneration, and reducing inflammatory responses through functional cells (e.g., mesenchymalstem cells), cytokines (e.g., VEGF), and drugs (e.g., aminoguanidine). However...

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Problems solved by technology

However, the effect is often unsatisfactory, and the following problems may also exist in actual use: 1) the transplanted cells lack normal tissue structure in the local area, and the survival rate and differentiation rate are low; 2) the cytokines are unevenly distributed locally and easily destroyed Normal tissue structure; 3) The release and clearance of drugs are difficult to predict and control; 4) It takes at least 7 days for microvessels to mature from neogenesis, and the reconstruction of microcirculation takes a certain amount of time

[0004] However, the accuracy of the existing method is difficult to make the diameter of the tube less than 600 μm, and the structure cannot completely simulate the hollow tube. 20-200μm diameter) are difficult to simulate remodeling by existing means; at the same time, the process is cumbersome and the controllability is not good, thus limiting the exploration of the early stage of microvascular regeneration

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