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A nitrogen-containing organic acid compound in purslane and its extraction and separation method and use

A separation method, the technology of purslane, applied in the direction of organic chemistry, food ingredients containing natural extracts, food extraction, etc., can solve the problem of low structural novelty, and achieve the effect of environmentally friendly process method, simple and fast operation method

Active Publication Date: 2022-05-13
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • A nitrogen-containing organic acid compound in purslane and its extraction and separation method and use
  • A nitrogen-containing organic acid compound in purslane and its extraction and separation method and use
  • A nitrogen-containing organic acid compound in purslane and its extraction and separation method and use

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Embodiment Construction

[0027] The invention provides a nitrogen-containing organic acid compound in purslane, the molecular formula is C 11 h 13 NO 6 , the chemical structural formula is:

[0028]

[0029] The new compound is named (2-(furan-2-yl)-2-oxoethyl)glutamic acid according to the structure, and Table 1 is the NMR data of the new compound: 1 H-NMR with 13 C-NMR in DMSO.

[0030] The nuclear magnetic data of table 1 novel compound of the present invention

[0031] serial number δC type δH,mult(J in Hz) 1 174.92 C 2 59.93 CH 4.17(m) 3 22.68 CH 2

2.00(m) 2.30(m) 4 28.82 CH 2.30(m) 5 174.92 C 1′ N 2′ 47.36 CH 2

4.30(d,18) 4.87(d,17.88) 3′ 182.95 C 1″ O 2″ 150.26 C 3″ 118.89 CH 7.56(d,3.54) 4″ 112.56 CH 6.74 (dd, 1.56; 3.48) 5″ 148.05 CH 8.03(d,1.02)

[0032] (2-(furan-2-yl)-2-oxoethyl)glutamic acid: purple oil, easily soluble in methan...

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Abstract

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a new compound extracted, separated and identified from purslane medicinal material and its extraction and separation method and application, specifically a method for extraction and separation of a nitrogen-containing organic acid compound in purslane and its application. The extraction and separation method of the new compound adopts ethanol extraction, silica gel column chromatography, polyamide column chromatography, macroporous resin column chromatography, ODS medium pressure column and Sephadex LH‑20 purification, liquid phase separation and preparation in sequence, and its structure adopts UHPLC‑ESI‑TOF‑MS, 1 H-NMR, 13 The method of C-NMR and two-dimensional nuclear magnetic spectrum analysis identified it as a new nitrogen-containing organic acid compound. The compound has potential anti-inflammatory and neuroprotective activities. The new compound and its salt or derivative can be used as a lead for the synthesis of other compounds, as well as a raw material for new drug development and pharmacological activity research, providing a lead for the development of new drugs and new components. and theoretical basis.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a new compound extracted, separated and identified from purslane medicinal material and its extraction and separation method, specifically a method for extraction and separation of a nitrogen-containing organic acid compound in purslane and its application. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane is drought and waterlogging resistant, light and shade resistant, widely distributed, and rich in resources. It has attracted much attention as a wild plant for both medicine and food. The 2015 edition of "Pharmacopia of the People's Republic of China" recorded the dry aerial parts of purslane as medicine. , has the functions of clearing away heat and detoxification, cooling blood to stop bleeding, and stopping dysentery. [000...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/52A61P29/00A61P25/00A23L33/105
CPCC07D307/52A61P29/00A61P25/00A23L33/105A23V2002/00A23V2200/30A23V2200/322A23V2250/21A23V2300/14
Inventor 英锡相英哲铭刘锡龙张文洁
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE