Traditional Chinese medicine composition for treatment of liver lenticular degeneration hepatic fibrosis and application

Abstract

The invention provides a traditional Chinese medicine composition for treatment of liver lenticular degeneration hepatic fibrosis. The traditional Chinese medicine composition is prepared from the following raw materials of radix rehmanniae preparata, fructus schisandrae, radix morindae officinalis, radix salviae miltiorrhizae, curcuma zedoary, rhizoma curcumae longae, radix et rhizoma rhei, herbalysimachiae and rhizoma coptidis. The invention further provides application of the traditional Chinese medicine composition to the treatment of liver lenticular degeneration hepatic fibrosis. According to the traditional Chinese medicine composition for the treatment of liver lenticular degeneration hepatic fibrosis, the action of tonifying the kidney and resolving the turbidity, and activatingthe blood and removing the stasis is achieved, the action of a Chinese herbal compound is performed in multiple links and at multiple levels for pathogenesis (copper metabolic block)-kidney deficiency, a key link (liver sternzellen activation and proliferation)-phlegm stagnation, the end (hepatic fibrosis)-accumulation and the like, and the characteristic of treating both the symptoms and root causes is achieved; theories of 'homogeny of the liver and kidney' and 'marrow losing and liver producing' of the traditional Chinese medicine are applied for the first time, and WD hepatic fibrosis is diagnosed and treated from the 'kidney'; and mutual confirmation is achieved from clinical and experimental aspects, the traditional Chinese medicine composition has the remarkable therapeutic effect on WD hepatic fibrosis, the purpose of treating both the symptoms and root causes is achieved, and good application prospects are achieved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating hepatolenticular degeneration and liver fibrosis and its application. Background technique [0002] Wilson disease (WD), also known as hepatolenticular degeneration (hepatolenticular degeneration), is an autosomal recessive disorder of copper metabolism. Cheng N et al. found that the incidence rate of this patient population is about 1.96 / 100,000. The disease rate is about 5.87 / 100,000. WD tends to occur in adolescents, and clinically, it mainly presents symptoms such as chronic liver disease, renal dysfunction, and nervous system disorders, and is a difficult disease involving multiple systems. [0003] The liver is the first and most important organ of copper metabolism in patients with hepatolenticular degeneration. Liver damage is the most common first symptom of WD patients at the age of 5-10 years. The pr...

AI Technical Summary

Problems solved by technology

There is a lack of effective methods for overall regulation: it can not only promote copper excretion, but also reduce adverse drug reactions;

[0009] 2. The treatment of liver fibrosis is mainly based on liver protection, but the mechanism of action of each liver protection drug is limited, and there is a lack of drugs that intervene in liver fibrosis through multiple channels and multi-target effects

Although there is no animal model that can fully replicate all the clinical features of WD, studies have shown (Li Yuwen, Wan Xiaohua, Ning Qin, et al. Copper overload leads to hepatocyte apoptosis and its effect on Bax Bcl-2 gene expression [J]. Chinese Journal of Contemporary Pediatrics, 2008,10(1):42-46.) The WD copper overload rat model can be used to simulate the process of liver damage induced by hepatic copper deposition, and has good repeatability and low price. It is easy to feed and other advantages. After 6, 8, and 12 weeks of copper loading, a large amount of copper ions can be observed in the liver cells. It is also found that the serum transaminases of rats after copper loading also increase, indicating that the function of liver cells in the copper loading rat model is affected. destruction, and there is a clear time-degree correlation

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