Autologous-regenerating repair dressing for caesarean incision and preparation method thereof

A caesarean section and autologous technology, applied in medical science, bandages, etc., can solve the problems of hemostasis, healing, and clinical needs of incision scars, and achieve the effects of reducing poor prognosis, good patient compliance, and reducing scarring

Inactive Publication Date: 2019-10-15
THE INT PEACE MATERNITY & CHILD HEALTH HOSPITAL OF CHINA WELFARE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it cannot meet the clinical needs of hemostasis, healing and scarring of incisions for special pregnant women.

Method used

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  • Autologous-regenerating repair dressing for caesarean incision and preparation method thereof
  • Autologous-regenerating repair dressing for caesarean incision and preparation method thereof
  • Autologous-regenerating repair dressing for caesarean incision and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A specific embodiment of the present invention, a kind of preparation method of cesarean section incision autologous regeneration repair dressing is as follows:

[0050] Step 1. Prepare the substrate

[0051] The polyacrylamide hydrogel was prepared, and the polyacrylamide hydrogel was used as the matrix.

[0052] Step 2. Preparation of Biocrosslinking Components

[0053] Chitosan, carboxymethyl cellulose and sodium alginate were aseptically treated, respectively, and prepared into 1.5% buffer solutions with a pH of 5.0, and then the three buffer solutions were mixed uniformly in a ratio of 1:1:1 , to obtain biocrosslinked components.

[0054] Step 3. Preparation of autologous functional components

[0055] Collect blood produced during cesarean section to prepare platelet-rich plasma, the steps are as follows:

[0056] Inject the blood into a centrifuge tube with a shunt mechanism and place it in a centrifuge for centrifugation;

[0057] The centrifuged blood is l...

Embodiment 2

[0066] A specific embodiment of the present invention, a kind of preparation method of cesarean section incision autologous regeneration repair dressing is as follows:

[0067] Step 1. Prepare the substrate

[0068] The polyvinylpyrrolidone hydrogel was prepared, and the polyvinylpyrrolidone hydrogel was used as the matrix.

[0069] Step 2. Preparation of Biocrosslinking Components

[0070] Chitosan, carboxymethyl cellulose and sodium alginate were aseptically treated, respectively, and prepared into 1.5% buffer solutions with a pH of 5.0, and then the three buffer solutions were mixed uniformly in a ratio of 1:1:1 , to obtain biocrosslinked components.

[0071] Step 3. Preparation of autologous functional components

[0072] Collect blood produced during cesarean section to prepare platelet-rich plasma, the steps are as follows:

[0073] Inject the blood into a centrifuge tube with a shunt mechanism and place it in a centrifuge for centrifugation;

[0074] The centrifuge...

Embodiment 3

[0082] A specific embodiment of the present invention, a kind of preparation method of cesarean section incision autologous regeneration repair dressing is as follows:

[0083] Step 1. Prepare the substrate

[0084] The polyacrylamide-sodium alginate hydrogel was prepared according to the mass ratio of 8:1, and the polyacrylamide-sodium alginate hydrogel was used as the matrix.

[0085] Step 2. Preparation of Biocrosslinking Components

[0086] After aseptic treatment of chitosan, it was prepared into a 1.5% buffer solution with a pH of 5.0;

[0087] 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide were respectively prepared into 0.8% buffer solution, and sterilized by filtration;

[0088] Then, the three buffers were mixed uniformly in a ratio of 1:1:1 to obtain a biocrosslinking component.

[0089] Step 3. Preparation of autologous functional components

[0090] Collect blood produced during cesarean section to prepare platelet-rich pl...

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Abstract

The present invention relates to an autologous-regenerating repair dressing for a caesarean incision. The dressing includes a matrix consisting of hydrogel, an autologous functional component, and a bio-crosslinking component. The bio-crosslinking component and the autologous functional component are mixed and then arranged on at least one surface of the matrix. The invention also relates to a preparation method of the dressing. The dressing is advantageous in that autoblood in caesarean can be effectively utilized, the prepared autologous functional component can effectively arrest bleeding,promote incision healing and suppress scar formation, the dressing can form good adhesion with skin without the need of other adhesive and fixing measures, and the dressing is high in biological safety and free of immunological risks.

Description

technical field [0001] The invention relates to the technical field of medical biological materials, in particular to an autologous regeneration repair dressing for a cesarean section incision and a preparation method thereof. Background technique [0002] Cesarean section is one of the important means to deal with difficult labor. With the increasing rate of cesarean section, incision nonunion or poor healing caused by incision infection, dehiscence, fat liquefaction and other factors after cesarean section are the main complications after cesarean section. Among them, the incision non-healing or poor healing caused by maternal obesity, anemia or advanced age is particularly prominent. In addition, with the improvement of the quality of life, the requirements for the quality of incision healing are also increasing. [0003] As a special group, pregnant and lying-in women have more special and prudent requirements for treatment methods. Factors such as changes in endocrine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0019A61L26/0023A61L26/0033A61L26/0038A61L26/0066A61L26/008
Inventor 范建霞丁政位晓娟
Owner THE INT PEACE MATERNITY & CHILD HEALTH HOSPITAL OF CHINA WELFARE INST
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