Daptomycin and composition of salts of Daptomycin
A technology of daptomycin and composition, which is applied in drug delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as differences in protective effects
Inactive Publication Date: 2019-10-18
JIANGSU HENGRUI MEDICINE CO LTD
View PDF7 Cites 2 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0003] In order to improve the storage stability of daptomycin in the form of lyophilized powder, it is necessary to add a lyoprotectant during the preparation of the lyophilized powder. There are many substances that can be used as a lyoprotectant. The commonly used lyoprotectant contains lactose , sucrose, raffinose, dextran, mannitol, inositol, galactose, ribose, xylose, mannose, cellobiose, maltose, trehalose, glycine, etc., but different lyoprotectants are in There are large differences in the protective effect of different drugs, therefore, finding a suitable protective agent to improve drug stability is a problem that researchers have been paying attention to
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0030] Embodiment 1: the preparation of daptomycin freeze-dried agent
[0031] A. Solution preparation
[0032] 20% daptomycin aqueous solution: Weigh about 5g of daptomycin into a 100mL beaker, add about 15mL of purified water, stir in an ice-water bath until dissolved (during the dissolution process, stir slowly with a magnet to avoid too much foam, do not Conducive to the later volume). Transfer to a 25mL volumetric flask, and make up to volume with purified water.
[0033] 4M NaOH solution: Weigh about 1.6g of sodium hydroxide into a 25mL beaker, add about 6mL of purified water and stir to dissolve, transfer to a 10mL volumetric flask, cool to room temperature, and dilute with purified water.
[0034] 1M NaOH solution: Weigh about 0.8g of sodium hydroxide into a 50mL beaker, add about 15mL of purified water and stir to dissolve, transfer to a 20mL volumetric flask, cool to room temperature, and dilute with purified water.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention provides Daptomycin and a composition of salts of the Daptomycin, particularly relates to the field of medicines, and provides a Daptomycin preparation containing myo-inositol as excipients. The Daptomycin has better stability and reconstruction rate, and further, the antibacterial treatment effect can be increased.
Description
technical field [0001] The invention relates to the field of medicine and provides a composition of daptomycin or a salt thereof and a preparation method thereof. Background technique [0002] Daptomycin is a cyclic lipopeptide antibiotic used in the treatment of complicated skin and skin structure infections and bacteremia. Daptomycin for injection can be administered intravenously, and it is mainly stored in the form of lyophilized powder before it is prepared into a liquid form for injection, and it is dissolved and reconstituted before use. [0003] In order to improve the storage stability of daptomycin in the form of lyophilized powder, it is necessary to add a lyoprotectant during the preparation of the lyophilized powder. There are many substances that can be used as a lyoprotectant. The commonly used lyoprotectant contains lactose , sucrose, raffinose, dextran, mannitol, inositol, galactose, ribose, xylose, mannose, cellobiose, maltose, trehalose, glycine, etc., bu...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/10A61K47/10A61K9/19A61K9/14A61P31/04
CPCA61K9/0019A61K9/145A61K9/19A61K38/10A61K47/10A61P31/04
Inventor 鞠明珠王立坤韩江彬
Owner JIANGSU HENGRUI MEDICINE CO LTD