Co-assembled epitope vaccine and its application

An epitope vaccine and co-assembly technology, applied in the field of biomedical engineering, can solve the problems of ineffective stimulation of Th1 immune response, inability to meet tumor immunotherapy, weak immunogenicity, etc., to improve humoral immunity and enhance cellular immune response , strong specific effect
CN110339352BActive Publication Date: 2022-03-01INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Publication Date
2022-03-01

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Abstract

The invention discloses a self-assembled and co-assembled epitope vaccine and its application. The epitope peptide and small molecule polypeptide carrier including T cell epitope and B cell epitope are bonded by covalent bonds, self-assembled in aqueous solution, Adjust the concentration, form nanostructures through self-assembly of polypeptides, and then form nanostructures by the co-assembly of polypeptide sequences containing antigenic epitopes bonded to different epitope peptides in aqueous solution to form nanostructures and its role in the preparation / prevention of tumors application, so as to protect the polypeptide, change the existing form of the epitope polypeptide, enhance the recognition and uptake of the epitope polypeptide by antigen-presenting cells, improve the immunogenicity, and finally improve the cellular immune response and tumor immunotherapy effect of the epitope vaccine.
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Description

technical field

[0001] The invention belongs to the field of biomedical engineering, and in particular relates to self-assembled epitope vaccines and multi-epitope co-assembled multivalent vaccines and applications thereof. Background technique

[0002] Compared with traditional vaccines, epitope vaccines have more advantages, and their biggest advantage is that they can overcome the safety problems caused by traditional vaccines caused by virulence recovery or dispersal. In addition, the epitope vaccine itself is non-toxic and stable, which is in line with the direction of future vaccine development.

[0003] Among various molecules, stimulating the body with epitope peptides of cytotoxic T lymphocytes (CTL) of tumor antigens expressed on the surface of tumor cells can generate antigen-specific CTL cells to participate in the tumor immune response. The mechanism is that after stimulating the body with CTL epitope peptides, it can cause the clonal proliferation of antigen-s...

Claims

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