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Particle size grading method of micro-nano-scale emulsion droplets and solid particles

A solid particle, micro-nano-scale technology, applied in the field of chemistry, can solve problems such as uncontrollable drug release speed, uneven micro-nano spheres, large particle size side effects, etc., to overcome poor separation effect, maintain nutritional components, and improve release drug speed effect

Pending Publication Date: 2019-10-18
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, droplets with inhomogeneous particle sizes are prone to coalescence, leading to emulsion delamination or rupture, reducing the stability of the emulsion
In addition, in many fields, the particle size inhomogeneity will have great side effects
For example, in food applications, the rupture of droplets with non-uniform particle size after aggregation will lead to the destruction of the nutritional content of the food; in terms of drug release, the polydispersity of the droplet size will make the internal drug flow into the outside of the droplet. Systemic administration will cause problems such as poor targeting, uncontrollable drug release rate, easy clogging, low bioavailability of drugs, and poor repeatability; in biochemical separation, the polydispersity of emulsion particle size will lead to micro-nano The inhomogeneity of the ball, when it is used as a separation medium, the micro-nano balls with small particle size will fill the gaps of the large-sized microspheres after packing, weakening the separation effect

Method used

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  • Particle size grading method of micro-nano-scale emulsion droplets and solid particles
  • Particle size grading method of micro-nano-scale emulsion droplets and solid particles
  • Particle size grading method of micro-nano-scale emulsion droplets and solid particles

Examples

Experimental program
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Effect test

Embodiment 1

[0035] 25mg of Fe 2 o 3 Add to 5mL of ethoxylated trimethylolpropane triacrylate, sonicate for 25min to make Fe 2 o 3 Disperse evenly. Weigh 0.33 g of ethoxylated trimethylolpropane triacrylate, 0.33 g of 2-(perfluorooctyl) ethyl methacrylate, 0.33 g of 0.4% F127 in 5 centrifuge tubes (aq) Mixing, on the basis of vortex oscillation for 3 minutes, use a homogenizer to shear the magnetic emulsion at a rate of 3500rpm, 5000rpm, 7000rpm, 11000rpm, and 20000rpm respectively, that is, prepare magnetic emulsions with different emulsification properties, and measure them with a micron particle size analyzer. The particle size of an emulsion; take 20μL emulsion and 1.6mL0.4%F127 (aq) Mix, shake up and down gently 20 times to dilute the emulsion, take the diluted emulsion and take a translational video under the microscope. Through statistical calculation, the quantitative relationship between the particle size and the translation velocity of the magnetic droplet is obtained.

[0...

Embodiment 2

[0039] Prepare 2g of magnetic emulsion, add 16g of ultra-pure water to dilute, invert the centrifuge tube up and down to mix evenly, pour it into the container, use a magnet to attract different times on the side close to the container, and take samples at a distance of 0cm from the magnet to measure the particle size. path.

[0040] verify: image 3 is a schematic diagram of particle size classification. From Figure 4 It can be seen that with the increase of time, the number of small-diameter magnetic liquid droplets at 0 cm increases gradually relative to the large-diameter magnetic liquid droplets.

Embodiment 3

[0043] Prepare 2g of magnetic emulsion, add 16g of ultrapure water to dilute, invert the centrifuge tube up and down to mix evenly, pour it into the container, use a magnet to attract different time on the side close to the container, and take samples at a distance of 6cm from the magnet to measure the particle size. path.

[0044] Authentication: from Figure 5 It can be seen that with the increase of time, the small-diameter magnetic liquid droplets at 6 cm gradually decrease compared with the large-diameter magnetic liquid droplets.

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Abstract

The invention provides a particle size grading method of micro-nano-scale emulsion droplets and solid particles. According to the method, the quantitative relation between the particle size of the droplets and the translational velocity is utilized to induce variable-velocity translation of the emulsion droplets containing magnetic particles through an external magnetic field, and therefore the emulsion droplets with the particle size within a micron-submicron-nano range are graded. Besides, by controlling magnetic field intensity, polymerization and sedimentation of the magnetic particles canbe induced, so that the magnetic particles in the droplets obtained after grading are removed, interference of the additional magnetic particles on emulsion properties and functions is avoided, and meanwhile cyclic utilization of iron oxide is realized. For an emulsion containing polymerizable monomers composed of internal-phase droplets, the solid particles with a uniform particle size can be obtained through ultraviolet light initiated polymerization or thermally initiated polymerization. In addition, multiple times of particle size grading treatment can be adopted to meet the application demand for high particle size uniformity. The method can provide technical support for application of the emulsion to food, medicine, biochemical separation, nanomaterials and other fields.

Description

technical field [0001] The invention relates to the field of chemistry, in particular to a particle size classification method for micro-nano-scale emulsion droplets and solid particles. Background technique [0002] Existing particle size classification technology is limited to solid-solid, solid-gas, liquid-gas and other polydisperse systems. For example, the utility model patent with the publication number CN1265045A discloses a method for classifying particulate drugs and mixed powders, and the utility model patents with the publication numbers CN205074226U and CN205797770U disclose the particle size screening method of aerosol particles and soil respectively. The utility model patent No. CN201959902U discloses a particle size screening device for an atomizer, the purpose of which is to solve the problem of uneven particle size in each system. An emulsion is a polydisperse system composed of two or more liquids. It is formed by the dispersion of one liquid in the form ...

Claims

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Application Information

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IPC IPC(8): G01N15/02
CPCG01N15/0272
Inventor 葛玲玲程静茹卞庆发童伟杰郭荣
Owner YANGZHOU UNIV
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