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Microcapsule and preparation method and application thereof

A technology of microcapsules and capsule materials, which is applied in the field of medicine to achieve the effects of improving bioavailability, good appearance roundness and uniform particle size

Inactive Publication Date: 2019-10-25
XIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the preparation of microcapsules using thuja volatile oil as the capsule core

Method used

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  • Microcapsule and preparation method and application thereof
  • Microcapsule and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 of the present invention is: a kind of microcapsule, and its preparation process comprises the following steps:

[0039] 1. Take 3g of gelatin and add 20ml of distilled water, soak and swell in a beaker, stir and dissolve in a constant temperature water bath at 50°C, then add distilled water to 100ml and stir evenly to obtain a gelatin emulsion, keep it warm at 50°C for later use;

[0040] 2. Take 3g of gum arabic and add 20ml of distilled water to soak. After swelling, stir and dissolve in a constant temperature (50°C) water bath.

[0041] 3. Take 3ml of thuja volatile oil, add 100ml of gum arabic solution, emulsify in a tissue homogenizer for 1min (speed 12000 rpm), transfer to a beaker to prepare colostrum, keep warm (50°C) for later use;

[0042] 4. Add the gelatin emulsion into the colostrum under stirring. After the mixing is complete, the pH of the mixture is measured to be 5.0;

[0043]5. After adjusting the pH value to 3.9 while stirring with acet...

Embodiment 2

[0045] Embodiment 2 of the present invention is: a kind of microcapsule, and its preparation process comprises the following steps:

[0046] 1. Take 3g of gelatin and add 20ml of distilled water, soak and swell in a beaker, stir and dissolve in a constant temperature water bath at 50°C, then add distilled water to 100ml and stir evenly to obtain a gelatin emulsion, keep it warm at 50°C for later use;

[0047] 2. Take 3g of gum arabic and add 20ml of distilled water to soak. After swelling, stir and dissolve in a constant temperature (50°C) water bath.

[0048] 3. Take 3ml of thuja volatile oil, add 100ml of gum arabic solution, put it in a tissue homogenizer for emulsification for 1min (speed 12000 rpm), transfer to a beaker to prepare colostrum, keep warm (50°C) for later use;

[0049] 4. Add the gelatin emulsion into the colostrum under stirring. After the mixing is complete, the pH of the mixture is measured to be 5.0;

[0050] 5. Adjust the pH value to 3.9 while stirring ...

Embodiment 3

[0052] Embodiment 3 of the present invention is: a kind of microcapsule, and its preparation process comprises the following steps:

[0053] 1. Take 3g of gelatin and add 20ml of distilled water, soak and swell in a beaker, stir and dissolve in a constant temperature water bath at 50°C, then add distilled water to 100ml and stir evenly to obtain a gelatin emulsion, keep it warm at 50°C for later use;

[0054] 2. Take 3g of gum arabic and add 20ml of distilled water to soak. After swelling, stir and dissolve in a constant temperature (50°C) water bath.

[0055] 3. Take 3ml of thuja volatile oil, add 100ml of gum arabic solution, put it in a tissue homogenizer for emulsification for 1min (speed 12000 rpm), transfer to a beaker to prepare colostrum, keep warm (50°C) for later use;

[0056] 4. Add the gelatin emulsion into the colostrum under stirring. After the mixing is complete, the pH of the mixture is measured to be 5.0;

[0057] 5. After adjusting the pH value to 4.0 with a...

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Abstract

The invention discloses a microcapsule and a preparation method and application thereof. The microcapsule is prepared from raw materials including volatile oil and capsule materials of thuja sutchuenensis. The preparation method includes: adding thuja sutchuenensis oil to an Arabic gum solution by stirring and emulsifying to obtain thuja sutchuenensis oil colostrum, and keeping warm for standby use; adding a gelatin solution to the colostrum while stirring, mixing to obtain a mixture, and controlling the pH value of the mixture to be between 3.8 and 4.0; adding water to the mixture, stirring to 32-35DEG C, rapidly cooling the mixture to be blow 10DEG C, adding formaldehyde in volume (0.3-0.5) times of the volume of asphalt, adjusting the pH value to 8-9, and separating out a microcapsule after standing; performing filtration and drainage to obtain the microcapsule. The preparation of the thuja sutchuenensis volatile oil into the microcapsule can not only improve inconvenient storage and transportation, but also improve the bioavailability, maximize the drug efficacy, increase the bioavailability of the thuja sutchuenensis volatile oil and increase the possibility of curing the disease.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a microcapsule and its preparation method and application. Background technique [0002] Thuja sutchuenensis (Thuja sutchuenensis) is an evergreen tree belonging to the genus Thuja in the Cupressaceae family. In recent years, under the influence of factors such as geography, ecological environment, acid rain, and global warming, the number of wild thuja has gradually decreased, and has been evaluated by the International Union for Conservation of Nature (IUCN). A world-class critically endangered species. [0003] Since Thuja thuja was rediscovered in 1999, the current researches are mainly focused on the population ecology, community ecology, genetic diversity and biological characteristics of Thuja thuja, and there are relatively few studies on its pharmacological effects, chemical components and quality evaluation. . Whether it is wood, leaves or fruits, thuja can emit a s...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K36/14A61K47/36A61K47/42A61P39/06A61P31/04A61P35/00A61P9/12A61P29/00A61P33/00A61P11/10A61P7/10A61P33/06
CPCA61K9/5036A61K9/5057A61K9/5089A61K36/14A61P7/10A61P9/12A61P11/10A61P29/00A61P31/04A61P33/00A61P33/06A61P35/00A61P39/06
Inventor 张辉喻莉萍
Owner XIANGNAN UNIV
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