Light/temperature double sensitive hydrogel and preparation method thereof

A hydrogel and low-temperature technology, applied in the field of medical materials, can solve problems such as weak mechanical properties and poor stability, and achieve the effects of improving mechanical strength, shortening gelation time, and good development and application potential
CN110407954AInactive Publication Date: 2019-11-05OCEAN UNIV OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
OCEAN UNIV OF CHINA
Publication Date
2019-11-05
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a light / temperature double sensitive hydrogel and a preparation method thereof, wherein the temperature sensitive part of the hydrogel is obtained by introducing hydroxybutyl into a chitosan molecular chain (Patent No. 201110214776.X), and the free amino group of hydroxybutyl chitosan and the epoxy group of glycidyl methacrylate are subjected to a ring-opening reaction to introduce a photosensitive group so as to obtain the photosensitive part. According to the present invention, the methacrylylated hydroxybutyl chitosan hydrogel is in a solution state at a low temperature, can be subjected to flowing injection, and can form a hydrogel within 1 min when a temperature is raised to around 37 DEG C; a photoinitiator is added into a prepolymer solution, the obtained solution is exposed to ultraviolet light, and the photoinitiator generates free radicals to initiate methacryloyl-substituted chain polymerization, such that the strength of the gel is significantly enhanced; and the light / temperature double sensitive hydrogel has good application prospects in the fields of tissue engineering scaffolds or drug sustained-release delivery and the like.
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Description

technical field

[0001] The invention belongs to the technical field of medical materials, and relates to a preparation method of light / temperature dual-sensitive hydrogel. Background technique

[0002] Photocrosslinkable hydrogels derived from natural polymers are often used in tissue engineering due to their excellent biocompatibility and ability to facilitate cell growth. Because the structure of the hydrogel is very similar to the natural extracellular matrix, it provides a suitable microenvironment for cells and tissues. It has been found that some photocrosslinkable and thermosensitive gel-forming polymers may have great potential for various biomedical applications, such as injectable delivery systems and cell culture.

[0003] Chitosan is a naturally abundant polymer whose polysaccharide backbone is considered an attractive candidate for extracellular matrix replacement. It has proven biocompatibility and has been successfully used in a variety of applications rangi...

Claims

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