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Application of broad bean protein peptide in preparing drugs for treating inflammation and drug for treating inflammation
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A protein peptide and broad bean technology, applied in the field of medicine, to reduce the production of pro-inflammatory cytokines, reduce transcription, and inhibit the inflammatory response of VSMCs
Active Publication Date: 2019-11-12
SHANGHAI ACAD OF AGRI SCI
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[0006] At present, the research on the functional activity of broad bean mainly focuses on polyphenols, and there is no information on the use of broad bean peptides in the preparation of drugs for the treatment of inflammation and the treatment of diseases related to inflammation such as hypertension, atherosclerosis, coronary heart disease, myocardial infarction Reports on drugs for stroke
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Embodiment 1
[0044] Embodiment 1, the preparation of broad bean protein peptide Alcalase-1
[0045] The preparation method of broad bean protein peptide Alcalase-1 comprises the following steps:
[0046] (1), get dried broad bean protein powder 200g and pulverize, cross 60 mesh sieves, obtain sample for subsequent use;
[0047](2) Weigh 5g of the sample from step (1) and put it in a 500mL conical flask, add 150mL of water, add the enzyme Alcalase according to the ratio of 4% (w / w) of the substrate, at pH 7.0, 45°C Carry out enzymolysis, enzymolysis time is 2h, obtain enzymolysis solution;
[0048] (3) Centrifuge the enzymolysis solution in step (2), take the supernatant, concentrate to about 20mL, vacuum freeze-dry under the condition that the temperature is lower than -50°C and the vacuum degree is less than 15Pa, and the powder is obtained, which is faba bean protein Peptide Alcalase-1.
Embodiment 2
[0049] Embodiment 2, the preparation of broad bean protein peptide Alcalase-2
[0050] The preparation method is basically the same as in Example 1, the difference is that: add 100mL of water, add the enzyme Alcalase according to the ratio of 3% (w / w) of the substrate, and carry out enzymolysis at pH 8.0, 50°C, the enzymolysis condition is 4h, Obtain enzymatic solution.
[0051] After step (3), broad bean protein peptide Alcalase-2 is obtained.
Embodiment 3
[0052] Embodiment 3, the preparation of broad bean protein peptide Alcalase-3
[0053] The preparation method is basically the same as in Example 1, except that 50mL of water is added, and the enzyme Alcalase is added according to the ratio of 2% (w / w) of the substrate, and the enzymolysis is carried out at pH 9.0 and 55°C. The enzymolysis condition is 6h, Obtain enzymatic solution.
[0054] After step (3), broad bean protein peptide Alcalase-3 is obtained.
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Abstract
The invention discloses application of broad bean proteinpeptide in preparing drugs for treating inflammation, and in particular application in preparing drugs for treating inflammation of vascular smooth muscle cells. The broad bean proteinpeptide can also be used to prepare drugs for treating diseases associated with the inflammation, and the diseases include hypertension, atherosclerosis, coronary heart disease, myocardial infarction, apoplexy, etc. The invention also provides a drug for treating inflammation, and the drug comprises the broad bean proteinpeptide, and a pharmaceutically acceptable carrier or auxiliary material. According to the present invention, the bioactive peptide is extracted from broad beans, the above application can be realized, and the application has very important medical and economic significance.
Description
technical field [0001] The invention belongs to the technical field of medicines, in particular, it provides the application of a broad bean protein peptide in the preparation of medicines for treating inflammation and the medicines. Background technique [0002] Inflammation is the body's defense response to stimuli, including injury, tissue damage, and infectious pathogens. It is an adaptive immune response, which includes chronic inflammation and acute inflammation. Oxidative stress and inflammation in the body promote and inhibit each other, and the two have an inseparable internal relationship. The activation of inflammatory signaling intermediates is achieved by regulating the thiol (R-SH) group that modifies ROS / GSH. The generation of excessive reactive oxygen species (ROS) disrupts the redox balance of the body, and through the nuclear transcription factor κB (NF- κB) amplifies the inflammatory response, thereby inducing the transcription of pro-inflammatory cytokin...
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