Preparation method of composite drug-loaded delivery material based on hydrogel and liposome

A liposome and hydrogel technology, applied in prosthesis, medical science, tissue regeneration, etc., can solve the problem of fast release, achieve good compatibility and achieve long-term slow release effect

Inactive Publication Date: 2019-11-15
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to solve the technical problem of rapid release of drug-loaded hydrogel as a scaffold material for cartilage defect repair, and to provide a preparation method for a hydrogel and liposome composite scaffold material

Method used

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  • Preparation method of composite drug-loaded delivery material based on hydrogel and liposome
  • Preparation method of composite drug-loaded delivery material based on hydrogel and liposome

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specific Embodiment approach 1

[0013] Embodiment 1: The preparation method of the composite drug-loaded delivery material based on hydrogel and liposome in this embodiment is implemented according to the following steps:

[0014] 1. Preparation of liposomes: Dissolve lipids and drugs in an organic solvent in a container. After fully dissolving, remove the organic solvent by rotary evaporation, form a liposome film on the surface of the container, add a buffer solution, and shake fully to make the lipids The body membrane is hydrated and shed to obtain a liposome solution;

[0015] 2. Preparation of composite drug-loaded delivery material: fully mix the liposome solution obtained in step 1 with the polyethylene glycol solution, and after mixing evenly, add chitosan solution or chitosan derivative solution, and let it stand A composite drug-loaded delivery material based on hydrogel and liposome is obtained.

[0016] In step 2 of this embodiment, the chitosan solution and the polyethylene glycol solution are...

specific Embodiment approach 2

[0018] Embodiment 2: This embodiment is different from Embodiment 1 in that the lipid described in step 1 is phospholipid or cholesterol.

specific Embodiment approach 3

[0019] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that the drug described in step 1 is a drug for cartilage defect repair or a factor that promotes cartilage differentiation.

[0020] The drug described in this embodiment may be chondroitin sulfate, kartogenin (KGN) and the like.

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Abstract

The invention relates to a preparation method of a composite drug-loaded delivery material based on a hydrogel and liposome, which belongs to the technical field of biomaterials, and aims to solve thetechnical problem of fast release of the hydrogel as a scaffold material for repairing cartilage defects. The preparation method comprises the following steps: 1. dissolving the lipid and a drug in acontainer in an organic solvent, after fully dissolving, removing the organic solvent by rotary evaporation, forming a liposome film on the surface of the container, adding a buffer solution, and fully shaking the material to make the liposome film for hydration shedding to obtain a liposome solution; and 2. thoroughly mixing the liposome solution and a polyethylene glycol solution, adding a chitosan solution or a chitosan derivative solution, and obtaining the composite drug-loaded delivery material based on the hydrogel and the liposome after standing. The liposome of the present inventioncan be loaded with the drug to achieve long-term slow release, and can be used as a carrier delivery system for the drug; and the drug and the liposome have synergism to achieve long-term slow releaseof the drug loaded on a stent material.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a preparation method of a composite drug-loaded delivery material. Background technique [0002] At present, the injury rate of articular cartilage in my country is as high as 10%-17%, accounting for 60%-70% of all joint diseases. However, chondrocytes have a very limited ability to migrate and have no blood supply, so articular cartilage has a very limited ability to repair itself. Once the articular cartilage is damaged, it is difficult to regenerate. If it is not treated in time, 75% will develop into osteoarthritis (OA). In the later stage of osteoarthritis, joint replacement surgery is required, which is expensive and will bring great pain to the patient. Quality drops. [0003] The rise of cartilage tissue engineering provides a new direction for the repair of articular cartilage. The three basic elements of cartilage tissue engineering are: scaf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/54A61L27/50A61L27/44A61L27/20A61L27/18
CPCA61L27/18A61L27/20A61L27/44A61L27/50A61L27/52A61L27/54A61L2430/06C08L5/08C08L71/02
Inventor 朱飞燕朱天飞蔡高锐熊建义
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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