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Vascular protection tape and its preparation method and application

A protective band and blood vessel technology, which is applied in the field of medical devices, can solve the problems of complete collagen structure destruction, crosslinking agent residue, and vascular digestive juice corrosion, etc., and achieve the effect of good adhesion, soft texture, and low antigenicity

Active Publication Date: 2022-01-04
何浩明 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through the enzymatic hydrolysis step, collagen is easily soluble in water, which is convenient for its subsequent separation and purification, but its fatal defects are: 1. The complete structure of collagen is destroyed, and its biological activity is completely lost. protein becomes biologically inactive gelatin
2. It is impossible to directly form a collagen film with sufficient strength. Although the use of cross-linking can increase its strength and prolong the degradation time in the body, it brings the problem of residual cross-linking agent and reduces its biological safety. It increases the burden on the liver during its metabolism, which is especially unacceptable for people undergoing hepatobiliary surgery
[0007] Therefore, in radical surgery for malignant tumors of the digestive tract, blood vessels that have been cleaned by skeletonization are easily corroded by digestive juice due to the lack of protection of the original surrounding tissues, which has become an important hidden danger of secondary intra-abdominal hemorrhage
There are currently no specific preventive measures for this problem clinically

Method used

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  • Vascular protection tape and its preparation method and application
  • Vascular protection tape and its preparation method and application
  • Vascular protection tape and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] (Example 1, vascular protection tape and preparation method thereof)

[0049] The vascular protection tape of this embodiment is made of elongated collagen film, the chemical composition is completely composed of collagen, the width is 0.1cm1-2cm, and the thickness is 0.2-2mm. The length of the collagen fibers of the vascular protection zone or the greater the molecular weight of the collagen, the longer the degradation time in the body.

[0050] The preparation method of the above-mentioned vascular protection belt comprises the following steps:

[0051] ① Preparation of raw materials. Wash, clean and depilate cowhide (without mad cow disease) from a qualified slaughterhouse, and then use a piece of hide to remove the lower layer of flesh and upper epidermis to obtain a collagen fiber layer. Soak the fiber layer in 0.5% to 2% sodium carbonate solution, turn it constantly, and then dry it. The collagen fiber layer is added with acetone to degrease and air-dry several...

Embodiment 2

[0076] (Example 2, vascular protection tape and preparation method thereof)

[0077] The vascular protection tape of this embodiment is made of a strip-shaped collagen composite film, with a width of 0.1cm1-2cm and a thickness of 0.2-2mm.

[0078] The components and their mass percentages in the collagen composite film are as follows: 60% to 90% of collagen, 10% to 40% of degradable biopolysaccharides, wherein the degradable biopolysaccharides are sodium hyaluronate, cross-linked transparent One or more of sodium alginate, chitosan, dextran, and bacterial cellulose.

[0079] The biopolysaccharide in this example is composed of modified sodium hyaluronate and cross-linked sodium hyaluronate with a mass ratio of 1:1.

[0080] The modification method of sodium hyaluronate is: dissolve medical grade hyaluronic acid in water, carry out oxidation reaction with excess sodium periodate solution, add sodium bisulfite solution after the reaction to reduce unreacted residual oxidant, wa...

Embodiment 3

[0084] (Embodiment 3, blood vessel protection band)

[0085] The components and their mass percentages in the vascular protection tape of this embodiment are as follows: 75% collagen and 25% bacterial cellulose.

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Abstract

The invention discloses a blood vessel protection tape, a preparation method and application thereof. The blood vessel protection tape is formed by winding a strip-shaped collagen film or a strip-shaped collagen composite film. The blood vessel protection band is used to isolate blood vessels and tissue fluid, the blood vessels are blood vessels cleaned by skeletonization, and the tissue fluid is peritoneal pus or digestive fluid after radical resection of hepatobiliary and pancreatic malignant tumors. The present invention proposes for the first time that the strip-shaped collagen film and the strip-shaped collagen composite film are used as a vascular protection belt for the radical resection of digestive tract tumors, especially malignant tumors of the liver, gallbladder and pancreas. "After the lymphatic tissue is dissected, the surrounding arteries and veins can isolate and protect the blood vessels, preventing abdominal pus or digestive juice leaking from the anastomosis from corroding the blood vessels and causing massive bleeding.

Description

technical field [0001] The invention relates to a medical device, in particular to a blood vessel protection band and its preparation method and application. Background technique [0002] Collagen is the most abundant and widely distributed protein in animals. It is the main structural protein of the body and the main component of tissue and connective tissue. The amino acid chain structure of collagen's unique three-strand peptide chain helix results in its many useful properties, such as high tensile strength, biodegradability, low antigenicity, low stimulation and low cell activity, and cell growth-promoting properties. All these characteristics endow it with high biosafety and bioavailability, and also make it an ideal biomedical material. [0003] Collagen has a wide range of clinical applications. It has been confirmed that it can promote wound healing and the growth of granulation tissue. It has good hemostatic function, filling function and biological scaffold. The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/14A61L24/10A61L24/04A61L24/00
CPCA61L31/044A61L31/041A61L31/042A61L31/148A61L24/0042A61L24/102A61L24/043A61L2400/04C08L89/00
Inventor 俞文隆何浩明汪信孙东平
Owner 何浩明
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