Applications of L-arginine and derivative of L-arginine in preparation of cyclododecanoneoxime, and method used for preparing cyclododecanoneoxime

Abstract

The invention discloses applications of L-arginine and a derivative of L-arginine in preparation of cyclododecanoneoxime, and a method used for preparing cyclododecanoneoxime. The derivative of L-arginine comprises one or a plurality of components selected from L-arginine-L-glutamic acid, an L-arginine hydrochloride, and an L-arginine succinate. According to the preparation method, one or more than one components selected from L-arginine and the derivative of L-arginine are taken as auxiliary agents, cyclododecanone is reacted with hydroxylamine sulphate to prepare cyclododecanoneoxime. The auxiliary agents are capable of controlling iron ion content in the reaction system, inhibiting hydroxylamine sulphate decomposition, inhibiting cyclododecylamine generation, and increasing reaction selectivity, and are convenient to separate and recycle.

Description

technical field

[0001] The present invention relates to the use of a compound, in particular to the use of L-arginine and its derivatives for preparing cyclododecanone oxime, and also to a method for preparing cyclododecanone oxime through cyclododecanone. Background technique

[0002] Cyclododecanone oxime can be rearranged to produce laurolactam, which is a monomer of nylon dodeca. In industry, cyclododecanone and hydroxylamine sulfate are commonly used to react to form cyclododecanone oxime, and there are many literatures about the oximation reaction.

[0003] A method is described in GB1126495A, which uses cyclododecanone and hydroxylamine sulfate under the condition of pH=3-5, and uses hexahydrocumene as a solvent to undergo an oximation reaction to obtain cyclododecanone oxime, and simultaneously The use of two-stage countercurrent operations reduces the consumption of hydroxylamine sulfate, but does not mention how to solve the problem of the slower reaction rate of ...

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