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A kind of continuous production system of 4-aminoantipyrine

A technology of aminoantipyrine and production system, which is applied in the field of continuous production system of 4-aminoantipyrine, can solve the problems such as waste of manpower, low efficiency, uncontinuous production, etc., so as to avoid manpower and material resources, reduce Energy consumption, improve the effect of atomization

Active Publication Date: 2022-06-28
QINGDAO UNIV OF SCI & TECH +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing production system is batch type, and the next reaction can only be carried out after the reaction between antipyrine and sodium nitrite in the nitrosation reactor, the production cannot be continuous, the efficiency is low, and a lot of manpower is wasted

Method used

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  • A kind of continuous production system of 4-aminoantipyrine

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Embodiment

[0024] like figure 1 As shown, a continuous production system of 4-amino antipyrine comprises antipyrine sulfuric acid solution storage tank 1, sodium nitrite solution storage tank 2, N 2 Storage tank 3, impingement flow reactor 4, reducing agent storage tank 5, first buffer tank 6, second buffer tank 7, compressor 8, reduction reactor 9, hydrolysis tank 10, neutralization tank 11, product storage tank 12 , sulfuric acid storage tank 13, liquid ammonia storage tank 14, cold brine storage tank 15, cold brine recovery tank 16.

[0025] The impingement flow reactor 4 includes a straight cylindrical still body 41, an oval top cover 42 and a conical still bottom 43. The still body 41 is provided with an antipyrine sulfuric acid solution feeding port and sodium nitrite arranged up and down. The solution feeding port; the bottom of the kettle bottom 43 is provided with a discharging port, and the top of the top cover 42 is provided with an exhaust port;

[0026] The first spray gun...

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Abstract

The invention discloses a continuous production system for 4-aminoantipyrine, which comprises an antipyrine sulfuric acid solution storage tank, a sodium nitrite solution storage tank, an impingement flow reactor, a reducing agent storage tank, a reduction reaction kettle, Hydrolysis tanks, neutralization tanks and product storage tanks. A first spray gun is installed in the feed port of the antipyrine sulfuric acid solution of the impinging flow reactor, a second spray gun is installed in the feed port of the sodium nitrite solution, and an injector is installed in the feed port of the reducing agent. The antipyrine sulfuric acid solution storage tank is connected to the first spray gun, and the sodium nitrite solution storage tank is connected to the second spray gun; the reducing agent storage tank is connected to the injector; the discharge port of the impact flow reactor is connected to the reduction reaction kettle in turn , Hydrolysis tank, neutralization tank, product storage tank. The invention is a continuous production process of 4-aminoantipyrine, which is simple in operation and convenient for monitoring, avoids extra manpower and material resources consumed by starting and stopping intermittent production, and reduces energy consumption.

Description

technical field [0001] The invention relates to the field of medicine and chemical industry, in particular to a continuous production system of 4-aminoantipyrine. Background technique [0002] my country is the country with the largest export volume of Analgin in the world. As an important antipyretic and analgesic drug, the market demand for Analgin is very large. 4-Aminoantipyrine is an intermediate for the production of Analgin. The amount used is also very large, so it is particularly important to study a production system of 4-aminoantipyrine that is easy to operate, high in production efficiency and safe. [0003] The traditional production method of 4-amino antipyrine is as follows: antipyrine is nitrified by sodium nitrite, then reduced by ammonium bisulfite and ammonium sulfite, and then hydrolyzed by sulfuric acid and finally neutralized by liquid ammonia to obtain 4- Amino antipyrine. The existing production system is batch type, and the next reaction can be carr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D231/46
CPCC07D231/46
Inventor 张俊梅段振亚李文辰王磊王子福
Owner QINGDAO UNIV OF SCI & TECH
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