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Glycyrrhiza glabra L. extract composition with function of enhancing skin immune barrier, and preparation method and application thereof

A technology for extracting and compounding licorice glabra, which is applied in skin care preparations, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as impaired skin immune barrier function and achieve enhanced skin immune barrier function , good anti-allergic effect, and the effect of enhancing the skin immune barrier effect

Pending Publication Date: 2019-12-06
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defects and deficiencies of existing licorice whitening products that easily cause damage to the skin immune barrier function, and to provide a composition of licorice glabra extract that can enhance the skin immune barrier function

Method used

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  • Glycyrrhiza glabra L. extract composition with function of enhancing skin immune barrier, and preparation method and application thereof
  • Glycyrrhiza glabra L. extract composition with function of enhancing skin immune barrier, and preparation method and application thereof
  • Glycyrrhiza glabra L. extract composition with function of enhancing skin immune barrier, and preparation method and application thereof

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Embodiment 1

[0051] A licorice glabra extract composition with the function of enhancing the skin immune barrier, the licorice glabra extract composition is composed of the following components in mass percentage: glabridin 5%, licorice polysaccharide 30%, and glycyrrhizin saponin 65% .

[0052] Among them, glabridin, licorice polysaccharide and glycyrrhizin were purchased from Guangzhou Kanglun Biotechnology Co., Ltd.

Embodiment 2

[0054] A licorice glabra extract composition with the function of enhancing the skin immune barrier, the licorice glabra extract composition is composed of the following components in mass percentage: glabridin 47.5%, licorice polysaccharide 30%, and glycyrrhizin saponin 22.5% .

[0055] Among them, glabridin, licorice polysaccharide and glycyrrhizin were purchased from Guangzhou Kanglun Biotechnology Co., Ltd.

Embodiment 3

[0057] A licorice glabra extract composition with the function of enhancing skin immune barrier. The licorice glabra extract composition is composed of the following components in mass percent: glabridin 5%, licorice polysaccharide 55%, and glycyrrhizin saponin 40%.

[0058] Among them, glabridin, licorice polysaccharide and glycyrrhizin are extracted by the following method:

[0059] S1. Take licorice root decoction slices, crush them through a 20-mesh sieve, add 95% ethanol to extract according to the ratio of material to liquid 1:10, extract at a temperature of 70°C for 2 hours, filter to obtain the filtrate and filter residue, repeat the extraction once, and combine the filtrates , concentrated to the extract at 55°C, dissolved with 50% ethanol solution and then loaded, and made to flow through a chromatographic column containing no glabridin-free polymer, with a flow rate of 1BV / h. After loading, use 75% Elute with ethanol solution at a flow rate of 2 BV / h, collect the el...

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Abstract

The invention discloses a glycyrrhiza glabra L. extract composition with function of enhancing skin immune barrier, and a preparation method and an application thereof. The glycyrrhiza glabra L. extract composition consists of the following ingredients in parts by weight: 5-47.5% of glabridin, 30-50% of glycyrrhiza polysaccharide and the balance of glycyrrhizin. In the glycyrrhiza glabra L. extract composition, the glabridin, the glycyrrhiza polysaccharide and the glycyrrhizin are combined to generate a synergy effect so as to be favorable for eliminating side effects, including dry skins, irritation and the like, which may be generated when a product with a single whitening effect is used. The inhibition ratio of the glycyrrhiza glabra L. extract composition for tyrosinase can be 66.65%,the activity of the skin immune barrier is about 0.88, the composition has an excellent synergy effect on whitening and enhancing the skin immune barrier, and therefore, the skin is healthy, bright and moisturized. In addition, the light-colored glabridin is prepared through the purification of a specific molecularly imprinted resin, and therefore, the composition has a light color and high quality and is more suitable for preparing cosmetic products.

Description

technical field [0001] The invention relates to the technical field of daily cosmetics, in particular to a licorice glabra extract composition with the function of enhancing skin immune barrier and its preparation method and application. Background technique [0002] Traditional whitening methods to regulate melanin use tyrosinase inhibitors such as aminomercury, hydroquinone, and kojic acid, all of which have extremely serious side effects on the skin. Glabridin, which is derived from nature, has a good effect of inhibiting melanin, which fully shows that it has a broad market prospect in whitening products. Whitening products can produce whitening effect mainly by inhibiting melanin production, transportation and excretion through whitening ingredients, and promoting skin metabolism cycle, so as to achieve whitening effect. However, during this process, a large amount of water in the skin will also be digested, which will easily cause dry skin. At the same time, if a larg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/73A61K8/63A61K8/49A61Q19/00A61Q19/02
CPCA61K8/9789A61K8/498A61K8/63A61K8/73A61Q19/00A61Q19/02A61K2800/782A61K2800/84
Inventor 刘晓英太美灵杜志云林丽马诗经韩萍
Owner INFINITUS (CHINA) CO LTD
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