Rapid functional magnetic resonance imaging method for evaluating PM2.5-induced lung injury

A technology of functional magnetic resonance and imaging methods, which is applied in the generation of 2D images, image enhancement, image analysis, etc., can solve the problems of not being able to provide quantitative evaluation of lung exchange function, and achieve the effect of short scanning time and pain relief

Inactive Publication Date: 2019-12-13
WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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Problems solved by technology

The above methods can effectively detect PM2.5-induced lung injury, and can assess and quantify lung inflammation and oxidative stress damage, however, these methods are invasive and cannot provide quantitative assessment of lung exchange function in vivo

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  • Rapid functional magnetic resonance imaging method for evaluating PM2.5-induced lung injury
  • Rapid functional magnetic resonance imaging method for evaluating PM2.5-induced lung injury
  • Rapid functional magnetic resonance imaging method for evaluating PM2.5-induced lung injury

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Embodiment Construction

[0036] In order to make the above-mentioned purposes, features and advantages of the present invention more obvious and understandable, the following in conjunction with the attached Figure 1~4 Taking the hyperpolarized inert gas fast magnetic resonance imaging of rats under a 7T magnetic resonance imager as an example, the specific embodiment of the present invention will be described in detail.

[0037] A fast functional magnetic resonance imaging method for evaluating PM2.5-induced lung injury, comprising the following steps:

[0038] Step 1. Collect the hyperpolarized inert gas. The collected hyperpolarized inert gas is stored in a gaseous or solid state. If it is in a solid state, the solid hyperpolarized inert gas is sublimated into a gaseous state during use. hyperpolarized noble gases including hyperpolarized 3 He, hyperpolarized 83 Kr, hyperpolarized 129 Xe or Hyperpolarized 131 Xe.

[0039] Step 2. Carry out tracheal intubation on the anesthetized rat, connect th...

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Abstract

The invention discloses a rapid functional magnetic resonance imaging method for evaluating PM2.5-induced lung injury, wherein the method comprises the steps: continuously anesthetizing a rat, sendingthe rat into a cavity of a magnetic resonance scanner, and scanning a proton localization image to obtain position information of the lung of the rat; delivering hyperpolarized inert gas to the lungof the rat; obtaining lung multi-diffusion sensitive factor diffusion weighted rapid magnetic resonance images of the rat under different diffusion sensitive factors b; obtaining lung chemical shift saturation recoquite rapid magnetic resonance spectra of the rat under different exchange time tau; obtaining an alveolar tube inner diameter r and an alveolar tube outer diameter R; and calculating toobtain the alveolar depth h, the surface volume ratio SVR and the average lining interval Lm. The measurement mode has the advantages of no invasion, no ionizing radiation and short scanning time, and can relieve the pain of a subject in the detection process; gas exchange function information of the lung of the subject in vivo is obtained.

Description

technical field [0001] The invention relates to the technical field of magnetic resonance imaging, in particular to a fast functional magnetic resonance imaging method for evaluating PM2.5-induced lung damage. It is used for quantitative evaluation of PM2.5-induced lung physiological function damage based on hyperpolarized inert gas fast magnetic resonance. Background technique [0002] Air pollution is a major environmental concern affecting respiratory health worldwide, especially in developing countries. According to the 2012 Global Burden of Disease Assessment, approximately 3.2 million people die each year from outdoor particulate pollution. Air pollution, characterized by high concentrations of particulate matter (PM), has become a major threat to public health in China. Fine particulate matter (PM2.5) is one of the most important air pollutants with an aerodynamic diameter of less than 2.5 μM. Due to its small particle size and large surface area, it can carry vario...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055G06T7/00G06T7/60G06T7/62G06T11/00A61D7/04
CPCA61B5/055A61B2503/40A61B2503/42A61D7/04G06T7/0012G06T7/60G06T11/003G06T2207/10088G06T2207/30061G06T7/62
Inventor 周欣张鸣李海东李红闯孙献平娄昕叶朝辉
Owner WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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