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Application of sodium alginate diester in the preparation of drugs for preventing or treating tumor metastasis

A technology of sodium alginate diester and tumor metastasis, which is applied in the field of medicine to achieve the effect of increasing clinical indications, cheap price and remarkable effect

Active Publication Date: 2020-09-04
MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no research report on the application of PSS in the treatment of tumor metastasis

Method used

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  • Application of sodium alginate diester in the preparation of drugs for preventing or treating tumor metastasis
  • Application of sodium alginate diester in the preparation of drugs for preventing or treating tumor metastasis
  • Application of sodium alginate diester in the preparation of drugs for preventing or treating tumor metastasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1, PSS inhibits tumor lung metastasis induced by B16F10 cells

[0030] 1) 60 male C57BL / 6J mice were weighed and divided into healthy group, model group (injection of tumor cells), PSS30mg / kg group (injection of tumor cells and PSS solution), PSS 20mg / kg group (injection of tumor cells) and PSS solution), PSS10mg / kg group (injection of tumor cells and PSS solution). Half an hour after each group of PSS was administered according to the dose (the model group was injected with normal saline), the model group and the PSS administration group were injected with melanoma B16F10-luc cells 0.1 mL / 3×10 in the tail vein of C57BL / 6J mice. 5 pcs / only. Start recording on the day when the mouse tumor was planted, continue to administer once a day until the 21st day after the mouse tumor was planted, first inject fluorescein, and take pictures with a small animal imaging system 15 minutes later, take out the lung tissue, take pictures, and weigh the lung tissue. Weight, lun...

Embodiment 2

[0035] Example 2, PSS inhibits tumor lung metastasis induced by B16BL6 cells

[0036] Forty male C57BL / 6J mice were weighed and equally divided into blank group, model group, PSS 45mg / kg group and PSS30mg / kg group. Half an hour after administration, melanoma B16BL6 cells were injected into the tail vein of C57BL / 6J mice at 0.1 mL / 3×10 5 pcs / only. The recording was started on the day when the mouse tumor was planted, and continued to be administered once a day until the 21st day after the mouse tumor was planted. The mice were sacrificed after blood collection, the lung tissue was taken out, and the number of melanoma nodules metastasized to the lung was counted, and the lung tissue was fixed with paraformaldehyde solution for H&E staining.

[0037] Depend on image 3 A shows that there are generally more melanoma nodules in the lungs of the model group, and the number of melanoma nodules is significantly reduced after the action of PSS, and the number of nodules in the high...

Embodiment 3

[0038] Example 3, PSS inhibits the lung metastasis of tumor induced by A549 cells

[0039] 36 male nu / nu mice were weighed and equally divided into blank group, model group, PSS 45mg / kg group, and PSS 30mg / kg group. Half an hour after administration, inject A549-luc cells 0.1mL / 8×10 into the tail vein of nu / nu mice 5 pcs / only. The recording was started on the day when the mouse tumor was planted, and continued to be administered once a day until the 21st day after the mouse tumor was planted. First, fluorescein was injected, and 15 minutes later, the small animal imaging system was used to take pictures. The mice were sacrificed after blood collection, and the lung tissue was taken out, fixed with paraformaldehyde solution, and the number of tumor nodules metastasized to the lung was counted, and H&E staining was performed.

[0040] The artificial lung metastasis model was established by injecting A549-luc cells into the tail vein of nu / nu mice, and the inhibitory effect of ...

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Abstract

The invention provides an application of polysaccharide sulfate in preparation of a medicine for preventing or treating tumor metastasis. The polysaccharide sulfate has the advantages of being high insafety and small in bleeding side effect, the polysaccharide sulfate is derived from the ocean, raw materials are easy to obtain, and the price is low. The experiments further prove that the polysaccharide sulfate has the effect of inhibiting tumor lung metastasis and liver metastasis, the effect is remarkable, the clinical indications of the polysaccharide sulfate are increased, the defects of the anti-tumor metastasis drug market are overcome, and the polysaccharide sulfate has important economic and social values.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of sodium alginate diester in the preparation of medicines for preventing or treating tumor metastasis. Background technique [0002] Tumor metastasis has always been one of the main causes of death in cancer patients, and 90% of clinical cancer patient deaths are caused by tumor metastasis. Tumor metastasis involves many factors, including not only changes in the characteristics of tumor cells themselves, but also changes in the host environment. The tumor microenvironment is a dynamic network, including tumor cells, extracellular matrix, and interstitial tissue, which is a key factor affecting tumor metastasis. The tumor microenvironment refers to the local homeostatic environment related to tumorigenesis and metastasis, which is composed of tumor cells and non-tumor cells during the growth of tumors. It mainly includes tumor cells, endothelial ce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/737A61P35/04
CPCA61K31/737A61P35/04
Inventor 邱培菊管华诗杨金波马赫李春霞王鑫赵晨阳
Owner MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD
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