Black biological activated ceramic powder and application thereof

A technology of bioactive ceramics and bioceramics, used in prostheses, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of non-degradable nanomaterials, difficult self-healing of the body, tissue defects, etc., and achieve good biological safety. , the effect of increasing the absorption

Active Publication Date: 2019-12-20
中科硅肤康(济宁)医疗器械科技有限公司
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, large tissue defects will be caused after surgical resection of the tumor, and it is difficult for the body to heal itself. Allogeneic tissues, artificial tissues or prostheses need to be reimplanted for defect repair and tissue function reconstruction [9]
Our previous studies have shown that c

Method used

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  • Black biological activated ceramic powder and application thereof
  • Black biological activated ceramic powder and application thereof
  • Black biological activated ceramic powder and application thereof

Examples

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preparation example Construction

[0060] Preparation of black bioactive ceramic composite membranes. The black bioactive ceramic powder, binder, and solvent are mixed as raw materials, and after vacuum filtration and drying, a black bioactive ceramic composite membrane material is obtained. The binder can be biopolymer materials such as chitosan (CTS), gelatin, sodium alginate, chitin, hyaluronic acid, collagen, polyvinyl alcohol, polyethylene glycol, and polylactic acid. Wherein, the mass ratio of the black bioactive ceramic powder to the binder may be 1:(0.1-2). The solvent can be an acidic solution such as acetic acid, hydrochloric acid, phosphoric acid, nitric acid, etc.

[0061] As a preparation example of a black bioactive ceramic composite membrane, it includes: dispersing the black bioactive ceramic powder in an acidic solution of chitosan, and controlling the mass ratio of the black bioactive ceramic powder to chitosan to be 1:0.1- 2. After stirring evenly, carry out vacuum filtration. Wherein, the...

Embodiment 1

[0082] Take 1g white CaSiO 3 The ceramic powder (WCS) is mixed with Mg powder (0.1g, 0.4g, 0.6g, 0.8g) of different qualities, and then introduced into the alumina crucible boat;

[0083] Place the crucible boat in an argon atmosphere furnace, and raise the temperature at 2°C / min to a certain temperature (550°C, 600°C, 650°C, 700°C, or 750°C), and keep it warm for 4 hours. Naturally cool to room temperature, pickling and vacuum drying to obtain black calcium silicate ceramic powder. Among them, the black calcium silicate ceramic powder obtained by reaction at 650°C can be respectively recorded as BCS1, BCS4, BCS6, BCS8 powder;

[0084] 250mg chitosan powder was dissolved in 50mL acetic acid solution to obtain acidic CTS solution (5wt.%);

[0085] Weigh 250mg BCS4 powder and disperse in 10mL H 2 (3) mix 50mL of CTS solution with 10mL of BCS suspension, keep stirring, and add 2mL of ammonia water dropwise to obtain BCS-CTS suspension;

[0086] Draw 6mL of BCS-CTS suspension,...

Embodiment 2

[0093] Take 1g white CaSiO 3 Ceramic powder (WCS) and Mg powder (0.2g) are mixed evenly, then introduced into the alumina crucible boat;

[0094] Place the crucible boat in an argon atmosphere furnace, raise the temperature at 2°C / min to a certain temperature (550°C, 600°C, 650°C, 700°C, or 750°C), and keep it warm for 4 hours. Cool naturally to room temperature, then pickle and vacuum dry to obtain black calcium silicate ceramic powder;

[0095] The black calcium silicate ceramic powder obtained by reacting 0.2g Mg powder at 650°C is denoted as BCS2 powder;

[0096] 250mg chitosan powder was dissolved in 50mL acetic acid solution to obtain acidic CTS solution (5wt.%);

[0097] Weigh 250mg BCS2 powder and disperse in 10mL H 2 (3) mix 50mL of CTS solution with 10mL of BCS suspension, keep stirring, and add 2mL of ammonia water dropwise to obtain BCS-CTS suspension;

[0098] Draw 6mL of BCS-CTS suspension, select filter paper with a diameter of 5cm, and vacuum filter for 2mi...

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Abstract

The invention relates to a black biological activated ceramic powder and an application thereof. A white biological activated ceramic powder and an Mg powder are mixed and are put in an inert atmosphere, magnesiothermic reduction reaction is carried out for 1-12h at a temperature of 500-800DEG C, and then, acid pickling is carried out to obtain the black biological activated ceramic powder.

Description

technical field [0001] The invention relates to a black bioactive ceramic powder and its application in preparing materials for treating tumors and repairing tissue defects, belonging to the field of biological materials. Background technique [0002] Malignant tumors have become the second cause of human death (second only to cardiovascular diseases), and finding effective treatments has always been a global problem that plagues modern medicine [1,2] . The current common clinical treatment for solid tumors is surgical resection combined with radiation therapy (radiotherapy) and chemotherapy (chemotherapy) [3] . Because surgical resection is difficult to completely remove tumor cells, traditional chemotherapy and radiotherapy are usually used, and radiotherapy and chemotherapy will cause great toxic side effects to patients [4,5] . Compared with traditional treatment methods, photothermal therapy has the advantages of short treatment time, obvious treatment effect, and l...

Claims

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Application Information

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IPC IPC(8): C04B35/22C04B35/20C04B35/447C04B35/626A61K41/00A61P35/00A61L27/10
CPCA61K41/0052A61L27/10A61P35/00C04B35/20C04B35/22C04B35/447C04B35/6265
Inventor 吴成铁王小成常江
Owner 中科硅肤康(济宁)医疗器械科技有限公司
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