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Ecofriendly biofilm-disrupting antimicrobial formulations, their development, and their uses

A substance and microencapsulation technology, applied in skin care preparations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve skin and eye discoloration, worry about silver resistance, silver aquatic organisms Unfriendly etc.

Pending Publication Date: 2019-12-27
ALIRA HEALTH BOSTON LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Triclosan is a moderate antimicrobial agent with a microbial inhibitory concentration (MIC) of 125 μg / ml, but due to its high Toxicity makes it a serious problem in terms of potential negative impact on the environment
Silver has a respectable MIC of 7.5 μg / ml but may cause skin and eye discoloration
Unlike triclosan, there are 5266 entries in the ECOTOX database as concerns about silver resistance and serious concerns that silver is unfriendly to aquatic organisms

Method used

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  • Ecofriendly biofilm-disrupting antimicrobial formulations, their development, and their uses
  • Ecofriendly biofilm-disrupting antimicrobial formulations, their development, and their uses
  • Ecofriendly biofilm-disrupting antimicrobial formulations, their development, and their uses

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Experimental program
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Embodiment Construction

[0014] for SAS analysis, we rated human safety based on Toxnet HSDB database. We ranked safety using the following rating scale: 5) safe, 4) mildly irritating, 3) moderate, 2) high risk, 1) unacceptable, and "ND" not determined. About 20% of the compounds present a high risk to personal safety due to acute major toxicities including skin irritation, throat and lung irritation, atrial fibrillation, muscle pain, cooling sensation and burning sensation.

[0015] MICs for antimicrobial agents were derived from literature reviews and in vitro studies of five major oral care and five major wound care pathogens in our laboratory. Often only one species of bacteria is tested in the literature, making it difficult to determine whether the target is a broad-spectrum antimicrobial. Oral care pathogens tested included: Fusobacterium nucleatum ss vincentii, Porphyromonas gingivalis, Prevotella intermedia, Aggregatibacter actinomycetemcomitans and Proteus Streptococcus mutans. Wound ca...

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Abstract

A skin care, wound care, or oral care device, comprising an essential oil stabilized into a polymerizable substance.

Description

Background technique [0001] The present disclosure relates to antimicrobial formulations. [0002] Many antimicrobial formulations currently used in the wound care, skin, cosmetic and oral care industries include those that are toxic to the environment, are not broad-spectrum targeted and have long been suspect within the EU and US Food and Drug Administration (FDA) antimicrobial substances. [0003] In the oral care and skin industries, one of the common antimicrobial ingredients is triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol). Triclosan is currently used in a variety of consumer products, including toothpaste, soap, deodorant, fabrics and toys. Triclosan is a moderate antimicrobial agent with a microbial inhibitory concentration (MIC) of 125 μg / ml, but due to its high Toxicity raises serious concerns about potential negative impacts on the environment. According to the Ecotoxicology Database (ECOTOX) sponsored by the US Environmental Protection Agency, triclosan ha...

Claims

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Application Information

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IPC IPC(8): A61K8/11A61K8/18A61K36/00A61Q11/00A61Q19/00
CPCA61Q11/00A61Q19/00A61K8/11A61K36/54A61K8/73A61K8/731A61Q17/005A61K8/733A61K8/735A61K8/87A61K8/922A61K47/34A61K47/36A61K47/38A61Q19/10
Inventor M·C·桑德斯
Owner ALIRA HEALTH BOSTON LLC
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