Implantable type micro-nano electrode array chip in weightless-simulated rats and preparation method thereof

Abstract

The invention discloses an implantable type micro-nano electrode array chip and a preparation method thereof, and the chip comprises silicon needle substrates, micro-electrode arrays, a counter electrode, an electrochemical reference electrode and an electrophysiological reference electrode; wherein, the silicon needle substrates are distributed on the implantation part at the front end of the chip and the interface part at the back end of the chip; a plurality of microelectrodes are distributed on the upper surface of the tip end of each silicon needle, and the micro-electrodes form the micro-electrode arrays; and the counter electrode, the electrochemical reference electrode and the electrophysiological reference electrode are arranged on the single silicon needle or a plurality of different silicon needles at positions close to the micro-electrode arrays. The lengths of the micro-electrode array silicon needles are gradually decreased, and 4 groups of micro-electrode arrays are distributed on 4 silicon needles, used for simultaneously detecting electrophysiological signals of cerebral cortex, hippocampus and thalamus, so that multiple implantation injuries can be avoided, and long-time continuous detection can be realized.

Description

Technical field [0001] The invention relates to the technical field of micro-electromechanical system (MEMS) micro-processing of biosensors, and is an implantable micro-nano electrode array chip for simulating weightless rats and a preparation method thereof. Background technique [0002] In long-term space missions, astronauts will be in a continuous weightless environment, and the body will be in a state of stress for a long time, which will induce neuropsychological problems such as reduced cognitive function. Chinese astronauts suffered from serious insomnia while working in the space capsule. Therefore, in order to ensure the healthy and efficient work of astronauts in orbit, it is necessary to further explain the mechanism of the influence of special environmental factors in space on neurological function, especially sleep problems. A 30° tail suspension rat was used to simulate the effects of weightlessness environment, and the effects of simulated weightlessness environm...

AI Technical Summary

Problems solved by technology

There are two main categories. One is the needle-shaped microelectrode array developed by the University of Utah in the United States. This type of electrode uses a whole piece of single crystal silicon as a material to present a square electrode needle array. The tip is coated with a metal layer and is coated with polyimide. Layer insulation, its electrodes are limited by shape and size, and are mostly used for the detection of neurophysiological information in the cerebral cortex or shallower surface parts, and have limitations for deep brain measurement

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