Water-based compound adjuvant, application thereof and vaccine for cats

An adjuvant and water-based technology, applied in the field of biomedicine, can solve the problems of easy allergy and high irritation at the injection site, and achieve the effect of less allergy and less irritation.

Pending Publication Date: 2020-01-10
上海农林职业技术学院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, most of the existing cat vaccine adjuvants use oily adjuvants such as white oil, which are more irritating to the injection site and prone to unsafe reactions such as allergies

Method used

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  • Water-based compound adjuvant, application thereof and vaccine for cats
  • Water-based compound adjuvant, application thereof and vaccine for cats
  • Water-based compound adjuvant, application thereof and vaccine for cats

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] This embodiment provides an aqueous composite adjuvant and inactivated cat distemper vaccine, wherein the preparation method of the aqueous composite adjuvant is as follows: first weigh 0.5 mg of mycobacterium vaccae peptide for injection, 5 mg of astragalus polysaccharide, interleukin-7 10 μg, 0.1 mL of aluminum hydroxide gel, 100 mg of stabilizer, and set aside; then, under normal temperature conditions, mix the above-mentioned Mycobacterium vaccae peptides for injection, astragalus polysaccharide, interleukin-7, aluminum hydroxide gel, stabilizer and Sterile deionized water was mixed to prepare 1 mL of aqueous composite adjuvant. Wherein, Mycobacterium vaccae peptide for injection is a commercially available product of General Biosystems (Anhui) Co., Ltd.; Astragalus polysaccharide is a commercially available product of Xi'an Wanfang Biotechnology Co., Ltd., which is a water-soluble powder of 90% purity; interleukin- 7 is feline interleukin-7 expressed by Shanghai Bi...

Embodiment 2

[0028] This embodiment provides a water-based composite adjuvant and an inactivated vaccine for feline infectious rhinotracheitis, wherein the preparation method of the water-based composite adjuvant is as follows: first weigh 3 mg of mycobacitracin for injection, 1 mg of astragalus polysaccharide, Interleukin-7 100μg, aluminum hydroxide gel 0.2mL, stabilizer 300mg, set aside; then, under normal temperature conditions, the above weighed mycobacterium vaccae peptides for injection, astragalus polysaccharide, interleukin-7, aluminum hydroxide gel, stabilizer The adjuvant was mixed with sterile deionized water to prepare 1 mL of aqueous composite adjuvant. Wherein, Mycobacterium vaccae peptide for injection is a commercially available product of General Biosystems (Anhui) Co., Ltd.; Astragalus polysaccharide is a commercially available product of Xi'an Wanfang Biotechnology Co., Ltd., which is a water-soluble powder of 90% purity; interleukin- 7 is feline interleukin-7 expressed ...

Embodiment 3

[0031] This embodiment provides an aqueous composite adjuvant and inactivated feline calicivirus vaccine, wherein the preparation method of the aqueous composite adjuvant is as follows: first weigh 2 mg of mycobacterium vaccae peptide for injection, 3 mg of astragalus polysaccharide, interleukin- 7 50 μg, 0.15 mL of aluminum hydroxide gel, 300 mg of stabilizer, for later use; then, under normal temperature conditions, mix the above-weighed mycobacterium vaccae peptides for injection, astragalus polysaccharide, interleukin-7, aluminum hydroxide gel, stabilizer Mix with sterile deionized water to prepare 1 mL of aqueous composite adjuvant. Wherein, Mycobacterium vaccae peptide for injection is a commercially available product of General Biosystems (Anhui) Co., Ltd.; Astragalus polysaccharide is a commercially available product of Xi'an Wanfang Biotechnology Co., Ltd., which is a water-soluble powder of 90% purity; interleukin- 7 is feline interleukin-7 expressed by Shanghai Bioe...

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PUM

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Abstract

The invention discloses a water-based compound adjuvant, application thereof and a vaccine for cats and belongs to the technical field of biomedicine. Each milliliter of the water-based compound adjuvant comprises the following components: 0.5-3mg of injection mycobacterium vaccae peptides, 1-5mg of astragalus polysaccharide, 10-100[mu]g of interleukin-7, 0.1-0.2mL of aluminum hydroxide gel and 100-300mg of stabilizer. According to the water-based compound adjuvant provided by the embodiment of the invention, water is used as a solvent with relatively small stimulation on an injection positionand cannot easily cause allergy. The vaccine for cats, which is prepared by mixing the water-based compound adjuvant and antigen, is safe and efficient.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to an aqueous composite adjuvant, its application and a cat vaccine. Background technique [0002] Cats are very popular as pets. But its infectious diseases feline distemper, feline infectious rhinotracheitis, and feline calicivirus seriously threaten the health of cats. For these viral diseases, there is currently no specific drug for treatment, mainly vaccine prevention. [0003] However, most of the existing cat vaccine adjuvants use oily adjuvants such as white oil, which are more irritating to the injection site and prone to unsafe reactions such as allergies. Contents of the invention [0004] The purpose of the embodiments of the present invention is to provide an aqueous composite adjuvant to solve the problems raised in the above-mentioned background technology. [0005] In order to achieve the above purpose, embodiments of the present invention provide the follow...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61K39/23A61K39/265A61K39/12A61P31/20A61P31/22A61P31/14
CPCA61K39/39A61K39/12A61P31/20A61P31/22A61P31/14A61K2039/552A61K2039/55516A61K2039/55583A61K2039/55527A61K2039/55505A61K2039/5252C12N2750/14334C12N2710/16034C12N2770/16034
Inventor 张江高俊锋李娜娜徐莉刘颖赖志马晶晶韩相敏吴碧清
Owner 上海农林职业技术学院
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