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Syntheses method of cinnamic acid/o-chlorobenzoic acid bagasse xylan diester with anti-HIV activity

A technology of o-chlorobenzoic acid and a synthesis method is applied in the synthesis field of anti-HIV active cinnamic acid/o-chlorobenzoic acid bagasse xylan diester, and can solve problems such as insufficient anti-HIV activity and the like

Inactive Publication Date: 2020-01-24
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Abstract
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  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a synthetic method of anti-HIV active cinnamic acid / o-chlorobenzoic acid bagasse xylan diester in order to overcome the problems such as insufficient anti-HIV activity of bagasse xylan single-modified derivatives

Method used

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  • Syntheses method of cinnamic acid/o-chlorobenzoic acid bagasse xylan diester with anti-HIV activity
  • Syntheses method of cinnamic acid/o-chlorobenzoic acid bagasse xylan diester with anti-HIV activity
  • Syntheses method of cinnamic acid/o-chlorobenzoic acid bagasse xylan diester with anti-HIV activity

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Experimental program
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Embodiment

[0036] (1) Put 20 g of bagasse xylan in a vacuum constant temperature drying oven at 50° C. and dry for 24 hours to obtain dry-based bagasse xylan.

[0037] (2) Weigh 15g of cinnamoyl chloride into a 50mL beaker, add 20mL of analytically pure dichloromethane, stir at room temperature for 7 minutes to obtain an esterifying agent solution, pour it into a 100mL constant pressure dropping funnel, and set aside.

[0038] (3) Weigh 15g of bagasse xylan obtained in step (1), place it in a 250mL four-necked flask equipped with a stirrer, a thermometer, and a reflux condensing device, then add 30mL of analytically pure dichloromethane, 3mL of analytically pure triethylamine, and stirred at room temperature for 30 minutes to obtain a bagasse xylan activation solution.

[0039] (4) Raise the temperature of the system in step (3) to 60° C., start to add the esterification agent solution prepared in step (2) dropwise, and control the dropping time to 4 hours. After the esterification agen...

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Abstract

The invention discloses a synthesis method of cinnamic acid / o-chlorobenzoic acid bagasse xylan diester with anti-HIV activity. The method comprises: carrying out first-step esterification reaction ina dichloromethane solvent by using bagasse xylan as a main raw material, using cinnamyl chloride as an esterifying agent and using triethylamine as a catalyst to synthesize cinnamate bagasse xylan; and carrying out a second-step composite catalytic esterification reaction by using o-chlorobenzoyl chloride as an esterifying agent and using pyridine and N,N'-diisopropylcarbodiimide (DIC) as a composite catalyst to synthesize the cinnamic acid / o-chlorobenzoic acid bagasse xylan diester. According to the invention, through the two esterification reactions, the product has the properties of cinnamic acid bagasse xylan ester and o-chlorobenzoic acid bagasse xylan ester, has the enhanced biological activity, and widens the application range of the xylan derivative in the fields of biology, medicine and the like.

Description

technical field [0001] The invention relates to the field of fine chemicals, in particular to a method for synthesizing anti-HIV active cinnamic acid / o-chlorobenzoic acid bagasse xylan diester. Background technique [0002] AIDS is spreading rapidly around the world, seriously threatening human health and social development. The complex molecular structure of xylan endows it with unique biological activity, especially the great activity of xylan in anti-HIV virus has attracted the attention of researchers at home and abroad. Xylan has poor water solubility and low activity. Chemical modification such as esterification can make up for the defects of xylan, thereby improving the biological activity of xylan. Because it is difficult to study the space structure-activity relationship of xylan esterified derivatives, and related research mainly focuses on xylan monoesterified derivatives, such as synthetic xylan sulfate, xylan carboxylate, etc. The research on xylan diester der...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/14A61P31/18
CPCA61P31/18C08B37/0057
Inventor 李和平葛文旭杨锦武李明坤张淑芬郑光绿耿恺柴建啟杨莹莹
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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