Two-sided differential absorbable closure device

An occluder and heterosexual technology, which is applied in the field of bilateral heterosexual absorbable occluders, can solve problems such as inconsistent degradation rates of occluders, achieve the effects of reducing foreign body rejection, avoiding failure of occlusion, and improving the degree of absorbability

Active Publication Date: 2020-02-04
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In view of this, the purpose of the present invention is to address the problems existing in the prior art, and to provide a bilateral heterogeneous absorbable occluder with controllable degradation rate, through the differential setting of the double-disc polymer network structure , to solve the problem of

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0067] A bilateral heterosexual absorbable occluder with a structure such as figure 1 As shown, it consists of an occluder main body, a locking piece and a flow blocking membrane. The main body of the occluder is a fiber net woven with fiber filaments and has a good preset shape memory function. The main body of the occluder has a double-sided disc-shaped structure. The fiber filaments of the fiber web are heated and melted to form nodes and then gathered to form a closed body. The air-blocking membrane is fixed on the two umbrella discs by suturing, and the sutures for fixing the polymer material membranes are medical polymer material sutures. The locking piece has a through hole and an internal thread at one end, and a cylindrical structure without a through hole at the other end. One end of the locking piece is connected to the far end, and the other end is connected to the proximal end through threads, and the waist height is fixed by fixing both ends. The polymer fibers...

Embodiment 2

[0069] A bilateral heterosexual absorbable occluder with a structure such as figure 2 As shown, the polymer fibers of the umbrella disc on the left are polycaprolactone PCL filaments, and the right is PLLA filaments. The diameters of the polymer fibers are both 100 μm, so that they can be degraded within the same period of time in the heart.

Embodiment 3

[0071] A bilateral heterosexual absorbable occluder with a structure such as image 3 As shown, the polymer fiber used is made of PLLA, and the density of the fiber filaments in the grid structure of the left umbrella disk is twice that of the fiber filaments in the right disk, so that the degradation cycle of the occluder on both sides of the left and right atrium / ventricular unanimous.

[0072] In order to further verify the excellent effect of the present invention, the inventor has also carried out the following use experiments:

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Abstract

The invention particularly discloses a two-sided differential absorbable closure device, and belongs to the technical field of interventional medical devices. Through differential arrangement of a double-disc structure and a macromolecular reticular structure, the degradation rates of the two sides of the closure device on left and right atria and left and right ventricles are kept consistent. According to the two-sided differential absorbable closure device, the diameters of reticular macromolecular fiber on the left side and the right side and the density of the reticular structure are adjusted, a left disc and a right disc use the different macromolecular materials to optimize the degradation speed, thus the degradation speeds of the left side and the right side in the body are consistent, the degradation rates and repair of heart defects are synchronized, the foreign matter reject reaction can be reduced to the greatest extent, the risk of closure failure is avoided, and device guarantee is provided for interventional treatment of atrial septal defect.

Description

technical field [0001] The invention belongs to the technical field of interventional medical devices, in particular to an absorbable occluder, in particular to a bilateral heterosexual absorbable occluder. Background technique [0002] Atrial / ventricular septal defect is a common congenital structural heart disease. At present, ultrasound-guided percutaneous interventional therapy is the first choice for the treatment of congenital structural heart disease due to its mild trauma, safe operation and definite curative effect. [0003] At present, most occluders are made of metal alloy materials with shape memory function. After the occluder is implanted in the body, the tissue around the defect grows inward and completes endothelialization, and the occluder will exist at the defect site for life. Complications caused by metal occluders cannot be ignored, including atrioventricular block, thrombosis, valve damage, residual shunt, hemolysis, arrhythmia, nickel allergy, etc. ...

Claims

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Application Information

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IPC IPC(8): A61B17/00
CPCA61B17/0057A61B2017/00575A61B2017/00862A61B2017/00867A61B2017/00831A61B2017/00606
Inventor 王伟伟潘湘斌刘文帅欧阳文斌孔德领
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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