Core-shell structure fiber functional inorganic biological material as well as preparation method and application thereof

Abstract

The invention provides a core-shell structure fiber functional inorganic biological material and a preparation method and application thereof.The preparation method comprises the steps that bioactive inorganic matter powder and pore-forming particles with different components are mixed with a liquid or semi-fluid dispersing agent to form slurry, then the slurry passes through a core-shell nozzle to form fibers, and the fibers are dried to obtain the core-shell structure fiber functional inorganic biological material. And soaking, washing, drying and calcining the collected fibers. The length and the form of the core-shell structure fiber functional inorganic biological material and the thickness, the micropore size and the porosity of each layer of component can be adjusted. The core-shell structure fiber functional inorganic biological material can release various functional inorganic ions, can prevent infection and control inflammation, can promote bone injury and neighbor soft tissue synergistic regeneration and repair, and can be applied to human body skeleton muscle system tissue regeneration and repair medicine.

Description

technical field [0001] This application relates to biomedical materials, especially to the field of regeneration and repair of bone and adjacent soft tissue damage, prevention and control of side effects, and in particular to a core-shell structural fiber functional inorganic biomaterial, preparation method and application. Background technique [0002] Musculoskeletal injuries caused by various reasons, efficient and complete defect healing and regenerative repair are currently clinical problems. In terms of bone injury repair and reconstruction, people often use autologous bone or allogeneic bone grafting, or animal bone deep-processing products for filling and repairing. In the past 20 years, successive studies have proved that calcium-silicon (CaO-SiO 2 ) as the matrix of inorganic active ceramics, glass or glass-ceramic materials, can directly osseointegrate with bone tissue and regulate the immune system (Huang Y et al., ActaBiomater 2018,66:81-92), and can even inter...

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Problems solved by technology

[0007] 2) It is extremely difficult to achieve arbitrary wrapping of multiple inorganic components from inside to outside or arranged side by side, and it is also impossible to directly form a two-dimensional or three-dimensional (fiber network, fiber sponge, fiber scaffold, etc.) continuous porous skeleton structure over a long distance , and give play to a certain mechanical support, causing difficulties in the filling of large volume or area of ​​bone damage and the stability of particles (the particles are easy to roll and slip);

[0008] 3) The ability to regulate the distribution and content levels of the core layer components is poor, which will seriously affect the degradation efficiency of components in different layers in the core-shell structure;

[0009] 4) The prevention and control of bone trauma complications such as infection and inflammation by this kind of bioactive ceramic granular materials, as well as the synergistic promotion effect on the regeneration and healing of bone adjacent soft tissue injuries are seriously insufficient

[0010] Although electrospinning technology can produce inorganic nanofibers, the fibers often depend on the conductivity of the receiving carrier, the formed fibers are too small, and the pore space after accumulation is extremely low. The thin film material formed by electrospinning, after the fibers are deposited on the carrier Difficult to rearrange

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