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Polyvinyl alcohol-based antibacterial hydrogel and preparation method thereof

A polyvinyl alcohol and hydrogel technology, applied in the field of biological antibacterial materials, can solve the problems of poor mechanical properties and easy degradation, limit the application of chitosan, low immunogenicity, etc., achieve excellent antibacterial effect, improve mechanical properties and viscosity With the effect of performance and simple processing method

Active Publication Date: 2020-02-07
JIANGNAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Chitosan (Chitosan, CS) can be copolymerized by N-acetyl-D-glucosamine, which has physical and chemical properties such as adhesion and good air permeability, and also has low toxicity, low immunogenicity, antibacterial activity and good biological properties. Excellent properties such as degradability are often used in wound dressings. However, due to its poor hydrophilicity and water absorption swelling, it exhibits poor mechanical properties in a wet environment and has problems such as easy degradation, which greatly limits Application of Chitosan

Method used

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  • Polyvinyl alcohol-based antibacterial hydrogel and preparation method thereof
  • Polyvinyl alcohol-based antibacterial hydrogel and preparation method thereof
  • Polyvinyl alcohol-based antibacterial hydrogel and preparation method thereof

Examples

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Embodiment 1

[0032] Preparation of polyvinyl alcohol-based antibacterial hydrogel: Dissolve 0.25g of hydroxypropyltrimethylammonium chloride chitosan in 15mL of deionized water. After it is completely dissolved, add 10mL of 15% PVA-SbQ solution, and then add 2mL1 .5% CNC suspension (PVA-SbQ: CNC: hydroxypropyltrimethylammonium chloride chitosan mass ratio is 8:0.12:1), stirred at a slow speed for 2 hours, then stood for 0.5h, until bubbles After it is completely eliminated, pour it into a watch glass and place it at 40W / cm 2 Irradiated under ultraviolet light for 4 minutes to obtain polyvinyl alcohol-based antibacterial hydrogel.

[0033] combine figure 2 : First remove the hydrogel from the 2mL centrifuge tube, shake the hydrogel gently, and the centrifuge tube is not thrown off; further increase the weight, replace the centrifuge tube with a rubber strip, and the rubber does not fall off after sticking; Then replace the rubber with small pieces of wood, and the small pieces of wood ca...

Embodiment 2

[0035] Dissolve 0.1g hydroxypropyltrimethylammonium chloride chitosan in 15mL deionized water, after it is completely dissolved, add 10mL15% PVA-SbQ solution, then add 2mL1.5% CNC suspension (PVA-SbQ : CNC: hydroxypropyltrimethylammonium chloride chitosan mass ratio is 8:0.12:0.4), stirred at a slow speed for 2 hours, then stood for a period of 0.5h, after the bubbles completely disappeared, poured into a watch glass, Put on 40W / cm 2 Irradiated under ultraviolet light for 4 minutes to obtain polyvinyl alcohol-based antibacterial hydrogel.

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Abstract

The invention discloses a polyvinyl alcohol-based antibacterial hydrogel and a preparation method thereof, and belongs to the technical field of biological antibacterial materials. According to the preparation method, a blending method is utilized, and under specific conditions, a chitosan quaternary ammonium salt is added into PVA-SbQ and illuminated, so that the hydrogel with the antibacterial property is obtained. Compared with the existing PVA hydrogel added with other photo-crosslinking agents, the production is more environment-friendly, the antibacterial effect is very excellent, and compared with chitosan, the solubility of the chitosan quaternary ammonium salt is more excellent; the mechanical property and the adhesion property of the material can also be improved. The processingmethod is simple, the PVA-SbQ is used for directly forming the hydrogel through illumination, and compared with the mode that glutaraldehyde and other cross-linking agents are added into PVA, the polyvinyl alcohol-based antibacterial hydrogel is more environmentally friendly and safer and has wider application prospects.

Description

technical field [0001] The invention relates to a polyvinyl alcohol-based antibacterial hydrogel and a preparation method thereof, belonging to the technical field of biological antibacterial materials. Background technique [0002] Infectious diseases caused by pathogens such as viruses, bacteria and fungi are one of the main factors that threaten health. With the continuous improvement of people's requirements for quality of life and health, antibacterial products are getting more and more attention. Traditional antibacterial materials are to introduce some antibacterial agents on the surface or body of materials through chemical or physical methods to endow these biomedical materials with certain antibacterial ability. However, small molecule antibacterial agents of the antibiotic class are usually specific and easily lead to drug resistance of bacteria. Therefore, it is extremely urgent to develop antibacterial materials with broad-spectrum antibacterial ability. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/28C08L29/04C08L1/02C08L5/08
CPCC08J3/075C08J3/28C08J2329/04C08J2401/02C08J2405/08
Inventor 白绘宇王大伟黄锡迎李章康马丕明东为富
Owner JIANGNAN UNIV
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