Flurbiprofen-containing external preparation for skin

A technology of flurbiprofen and external preparations, which is applied in the field of poultice containing flurbiprofen, can solve the problems of poor adhesion of hydrogels, etc., and achieve the effect of solving poor adhesion

Pending Publication Date: 2020-02-14
BEIJING TIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, with the progress of research, the research on the transdermal permeability of hydrogel plaster drug stabilizer is getting more and more in-depth, and the stability and transdermal property of hydrogel plaster have also made some progress, but it is troubled by the majority of patients. The problem of poor adhesion of hydrogels has not been effectively solved

Method used

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  • Flurbiprofen-containing external preparation for skin
  • Flurbiprofen-containing external preparation for skin
  • Flurbiprofen-containing external preparation for skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 prescription screening

[0039] Table 1. Sample formulation 1

[0040] Material name Dosage (parts) Flurbiprofen 3.33 L-menthol 2 Cromiton 5 Isolactone myristate (IPM) 5 Tween 80 5 Sorbitan Sesquioleate 0.5 Polyvinyl alcohol (PVA) 20 gelatin 30 Polyacrylic acid 20 Aluminum glycylate 1.5 Edetate Sodium (EDTA) 2.18 Titanium dioxide 2.5 Sodium Carboxymethyl Cellulose (CMC-Na) 40 Polyacrylic acid-polyacrylic acid copolymer (NP700) 60 Kaolin 10 glycerin 280 Total amount of purified water 515.45 PH value 5.14 Average viscosity (2N) 30.1

[0041] Preparation:

[0042] Dissolve the prescribed amount of sodium carboxymethylcellulose in glycerin and partially purified water to obtain component A; dissolve the prescribed amount of gelatin in partially purified water, heat it after the expansion is complete, and stir until it becomes a trans...

Embodiment 2

[0068] The research of embodiment 2 linking agent

[0069] The present invention has carried out further research on the cross-linking agent in the prescription, and prescription is as table 3 below, and preparation method is as embodiment 1:

[0070] Table 3. Formulation Studies for Crosslinkers

[0071] Material name Prescription 21 Prescription 22 Prescription 23 Prescription 24 Prescription 25 Prescription 26 Prescription 27 Flurbiprofen (FP) 3.33 3.33 3.33 3.33 3.33 3.33 3.33 1-menthol 2 2 2 2 2 2 2 Cromiton 5 5 5 5 5 5 5 Isopropyl myristate (IPM) 5 5 5 5 5 5 5 Menthyl Lactate 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Tween 80 5 5 5 5 5 5 5 Sorbitan Sesquioleate (Span83) 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Polyvinyl alcohol (partially saponified) 20 20 20 20 20 20 20 Gelatin (New Field) 30 30 30 30 30 30 30 Polyacrylic acid (15%) 20 20 20 20 20 20 20 ...

Embodiment 3

[0073] The research of embodiment 3 fillers

[0074] The present invention has carried out further research on the filling agent in the prescription, and the prescription is as in Table 3, and the preparation method is as in Example 1:

[0075] Table 4. Formulation Studies for Fillers

[0076]

[0077] Composed of the above prescription and the results of the adhesion test ( image 3 ) shows that both titanium dioxide and kaolin as fillers can effectively improve the adhesion, but their dosage must be strictly controlled. When the dosage exceeds 50 parts, the paste will be too hard to achieve effective coating. At 2.5 parts, the paste is soft and there will be residue when used.

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Abstract

The invention discloses a flurbiprofen-containing external preparation for skin. The preparation is composed of a backing layer, a drug reservoir matrix layer and a protective film, the flurbiprofen-containing external preparation contains 1-10 parts of flurbiprofen, 30 to 100 parts of a gel skeleton component; 0.2-3.5 parts of a cross-linking agent, 1-4 parts of a cross-linking regulator, 1-15 parts of an accelerator, 5.0-52.5 parts of a filling agent, 1-10 parts of a bacteriostatic agent, 5.5-50 parts of a solubilizer and 40-160 parts of a tackifiers. The invention provides the flurbiprofen-containing external preparation, which is safe, effective, non-irritant, good in adhesion and not easy to fall off.

Description

[0001] This application is a divisional application with the application number CN201711163656.5, the application date of November 21, 2017, and the title of the invention "a skin external preparation containing flurbiprofen". technical field [0002] The invention belongs to the field of pharmaceutical preparations, and relates to an external skin preparation containing flurbiprofen, in particular to a poultice containing flurbiprofen. Background technique [0003] Acute and chronic orthopedic pain is the most common symptom of orthopedic diseases, with a high incidence and great harm. Oral non-steroidal anti-inflammatory drugs (NSAIDS) are mostly used for treatment. Due to the short duration of drug efficacy of oral preparations, repeated administration is prone to produce "peak and valley" phenomenon of blood drug concentration, resulting in poor curative effect or toxic side effects. And serious gastrointestinal side effects. Therefore, clinically, external application ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32A61K31/167A61K31/192A61P19/08A61P29/00
CPCA61K9/7023A61K47/32A61K31/192A61K31/167A61P19/08A61P29/00A61K2300/00
Inventor 卢迪吴昀蒲晓蕾高莹
Owner BEIJING TIDE PHARMA
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