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Application of sophorose in products for preventing and treating inflammatory bowel diseases and corresponding products

A technology for inflammatory bowel disease and products, which is applied in the field of prevention and treatment of inflammatory bowel disease, can solve problems such as insufficient safety, and achieve good effects and mild regulatory effects

Inactive Publication Date: 2020-02-14
ZHEJIANG HUAKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The patent with the publication number CN102526030A discloses a class of small molecule drugs that can effectively protect the body from free radical damage, thereby blocking the onset of inflammatory bowel disease, specifically involving 3,3'-diindolylmethane (DIM) and its Aqueous injection formulations and the parent compound indole-3-carbinol (I3C) in the treatment of inflammatory bowel disease, but the safety of such drugs is still insufficient

Method used

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  • Application of sophorose in products for preventing and treating inflammatory bowel diseases and corresponding products
  • Application of sophorose in products for preventing and treating inflammatory bowel diseases and corresponding products
  • Application of sophorose in products for preventing and treating inflammatory bowel diseases and corresponding products

Examples

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Embodiment 1

[0024] 1. Preparation of Sophorose

[0025] The sophorose involved in the following examples can be purchased or self-made, and it can be prepared by the following method: dissolve 10g steviol glycoside (98%) in 20mL-80mL formic acid solution, stir and react at 80°C for 30min-40min, and vacuum rotary steam Remove the reaction solvent, wash the obtained precipitate with 100mL ultrapure water, filter with suction, discard the precipitate, spin evaporate again, dissolve with 100mL ultrapure water, and keep the supernatant. The obtained solution was separated by a diatom-activated carbon chromatography column, followed by gradient elution with ultrapure water and 5v / v%-30v / v% ethanol solution, and the obtained solution was detected by HPLC. The solution was passed through a 0.22μm filter membrane, chromatographic conditions: chromatographic column: BioRadHPX-87H (300mm*7.5mm), detector: differential refractive index detector, temperature: 55 ° C, mobile phase: 5mM sulfuric acid, f...

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Abstract

The invention discloses application of sophorose in products for preventing and treating inflammatory bowel diseases, and further discloses the corresponding products of the sophorose. Research results prove that the sophorose can reduce inflammatory factor levels of inflammatory bowel disease model rats to a certain degree, and thus the sophorose can serve as a drug for treating the inflammatorybowel diseases and can also serve as a part of daily diet to prevent the inflammatory bowel diseases; and the sophorose has mild and good regulation effects, and compared with other drugs, the sophorose has no side effects.

Description

technical field [0001] The invention relates to the technical field of prevention and treatment of inflammatory bowel disease, in particular to the application of sophorose in products for the prevention and treatment of inflammatory bowel disease and corresponding products. Background technique [0002] Sophorose is a disaccharide formed by connecting two glucose through β-1,2-glucosidic bonds. It is expensive, only reagent grade, and has no industrial production. Due to the small production amount and high price of sophorose, it cannot be widely used in research. Now it is mainly used to induce Aspergillus or Trichoderma to produce cellulase, and its inducing effect is tens to thousands of times that of other inducing compounds such as lactose. A strong inducer. The molecular weight of steviol glycoside is 804.9, and the sophorose group at the C13 position accounts for 42% of the total molecular weight. It can be seen that in stevioside, sophorose accounts for a high prop...

Claims

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Application Information

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IPC IPC(8): A61K31/7016A61P1/00A23L33/125
CPCA61K31/7016A61P1/00A23L33/125A23V2002/00
Inventor 左齐乐陈德水石丽华朱炫韩菲菲陈杰陈跃文李勉张文瑶唐文娟柳艳云
Owner ZHEJIANG HUAKANG PHARMA
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