Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medical collagen oral ulcer protection gel and preparation method thereof

A technology for collagen and oral ulcers, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve problems such as inconvenient treatment, strong odor of oral ulcers, and long healing period. Achieve wide applicability and commercial value, promote wound healing, and be easy to use

Pending Publication Date: 2020-02-14
ZHENGZHOU KANG JINRUI HEALTH PHARMA CO LTD
View PDF8 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therapeutic drugs on the market are mainly watermelon cream and oral spray, but their disadvantages are that the healing period is long, and they are dependent, they will recur, the treatment is inconvenient, and they are easy to enter the abdomen; there are also externally applied drugs for oral ulcers. Strong odor, strong irritation to the oral mucosa, or powdery form that is easily inhaled into the airway, causing great pain and inconvenience to patients
[0005] At present, there is no medicament with simple compatibility and less harm to the human body

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medical collagen oral ulcer protection gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The medical collagen oral ulcer protective gel of this embodiment includes the following raw materials in parts by weight: 20 parts of type III collagen, 15 parts of type I collagen, 7 parts of excipients, and 2 parts of preservatives.

[0027] The excipient is mixed with carbomer, xylitol and propylene glycol according to the mass ratio of 1:1:2.5; the preservative is sodium propylparaben.

[0028] The molecular weight of type III collagen is 65.3kDa, and the molecular weight of type I collagen is about 40kDa.

[0029] The preparation method of the present embodiment medical collagen oral ulcer protection gel comprises the following steps:

[0030] S1. Weighing each raw material according to parts by weight;

[0031] S2. Add type III collagen and type I collagen to water at 45°C and stir for 30 minutes, wherein water accounts for 85% of the total mass of type III collagen and type I collagen, then add excipients and preservatives and continue stirring for 60 minutes. ...

Embodiment 2

[0033] The medical collagen oral ulcer protective gel of this embodiment includes the following raw materials in parts by weight: 40 parts of type III collagen, 35 parts of type I collagen, 20 parts of excipients, and 8 parts of preservatives.

[0034] The excipient is mixed with carbomer, xylitol and propylene glycol according to the mass ratio of 1:0.5:1.3; the preservative is sodium methylparaben.

[0035] The molecular weight of type III collagen is 65.3kDa, and the molecular weight of type I collagen is about 60kDa.

[0036] The preparation method of the present embodiment medical collagen oral ulcer protection gel comprises the following steps:

[0037] S1. Weighing each raw material according to parts by weight;

[0038] S2. Add type III collagen and type I collagen to water at 60°C and stir for 60 minutes, wherein water accounts for 95% of the total mass of type III collagen and type I collagen, then add excipients and preservatives and continue stirring for 120 minut...

Embodiment 3

[0040] The medical collagen oral ulcer protective gel of this embodiment includes the following raw materials in parts by weight: 30 parts of type III collagen, 25 parts of type I collagen, 14 parts of excipients, and 5 parts of preservatives.

[0041] The excipient is composed of carbomer, xylitol, and propylene glycol mixed in a mass ratio of 1.5:0.7:2; the preservative is selected from sodium methylparaben and sodium propylparaben in a mass ratio of 1:1. become. The molecular weight of type III collagen is 65.3kDa, and the molecular weight of type I collagen is 40-60kDa.

[0042] The preparation method of the present embodiment medical collagen oral ulcer protection gel comprises the following steps:

[0043] S1. Weighing each raw material according to parts by weight;

[0044] S2. Add type III collagen and type I collagen to water at 55°C and stir for 45 minutes, wherein water accounts for 90% of the total mass of type III collagen and type I collagen, then add excipient...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention provides a medical collagen oral ulcer protection gel and a preparation method thereof, and relates to the technical field of medical preparations. The medical collagen oral ulcer protection gel comprises the following raw materials: type III collagen, type I collagen, an excipient, and a preservative. The medical collagen oral ulcer protection gel has low medicine odor, and little irritation to the oral mucosa, and is used to relieve pains caused by wounds caused by oral ulcers, oral inflammation, dentures or surgeries, the wound healing is promoted, the curative effect is significant, fast anti-inflammatory and pain-relieving can be achieved, the use is simple, and thereby the protection gel has wide applicability and commercial value.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a medical collagen oral ulcer protective gel and a preparation method thereof. Background technique [0002] Oral ulcer, commonly known as "oral sore", is a common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip, tongue, tongue belly, buccal mucosa, vestibular groove, soft palate and other parts. The mucosa in these parts lacks stratum corneum. or poor keratosis. Tongue ulcers refer to oral ulcers that occur on the tongue and the abdomen of the tongue. When oral ulcers attack, the pain is severe, and the local burning pain is obvious. In severe cases, it will also affect eating and speaking, causing great inconvenience to daily life; Symptoms such as swollen lymph nodes. [0003] The occurrence of oral ulcers is the result of a combination of many factors, including local trauma, mental stress, food, drugs, malnu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K9/06A61P1/02
CPCA61K38/39A61K9/06A61K9/006A61K47/26A61P1/02
Inventor 张永红
Owner ZHENGZHOU KANG JINRUI HEALTH PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com