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Patulin magnetic molecularly imprinted polymer as well as preparation method and application thereof

A technology of magnetic molecular imprinting and patulin, applied in the field of detection, can solve the problems of difficult separation of imprinted polymers, high cost of detection and detection, poor adsorption capacity, etc., and achieve the effect of enhanced selectivity, increased adsorption rate, and improved adsorption capacity

Active Publication Date: 2020-02-14
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The imprinted polymer prepared by the copolymerization method has a large number of binding sites not on the surface of the polymer, which has poor adsorption capacity. It is difficult to separate the imprinted polymer from the actual sample, and the detection cost is high when combined with LC-MS.

Method used

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  • Patulin magnetic molecularly imprinted polymer as well as preparation method and application thereof
  • Patulin magnetic molecularly imprinted polymer as well as preparation method and application thereof
  • Patulin magnetic molecularly imprinted polymer as well as preparation method and application thereof

Examples

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Embodiment 1

[0042] A method for preparing a patulin magnetic molecularly imprinted polymer, comprising the following steps:

[0043] (1) Preparation of Fe by hydrothermal method 3 o 4 nanoparticles

[0044] FeCl 3 ·6H 2 O (1.38 g) + trisodium citrate (0.5 g) was dissolved in 40 mL of ethylene glycol. Add 1.2 g of sodium acetate to the above solution system, and stir until the solution is uniform (about 0.5 h). Transfer to a 50mL hydrothermal reactor and react at 200°C for 10h. Cool to room temperature. Repeatedly washed three times with ethanol and water for later use (vacuum drying at 55°C).

[0045] (2) Fe 3 o 4 @SiO 2 Preparation of microspheres

[0046] Accurately weigh 0.2g of magnetic Fe prepared in step (1) 3 o 4 Nanoparticles were placed in 100mL of 0.1mol / L hydrochloric acid solution, ultrasonically treated for 10min, then uniformly dispersed in 80mL of ethanol and 20mL of deionized water, added 2mL of 28% concentrated ammonia water and 1mL of tetraethylorthosilicate...

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Abstract

The invention discloses a preparation method of a patulin magnetic molecularly imprinted polymer. A preparation method comprises the following steps: preparing large-particle-size ferroferric oxide nanoparticles by a hydrothermal method, preparing Fe3O4@SiO2 microspheres, carrying out vinylation on the Fe3O4@SiO2 microspheres, and polymerizing to obtain the patulin magnetic molecularly imprinted polymer. The adsorption rate of the prepared patulin magnetic molecularly imprinted polymer is remarkably increased, adsorption equilibrium can be achieved within 60 minutes, the stable and reusable performance can still be kept after multiple times of regeneration, the specificity is high, and the preparation time is short. The prepared patulin magnetic molecularly imprinted polymer is more beneficial to rapid detection sample pretreatment of patulin.

Description

technical field [0001] The invention belongs to detection technology, and in particular relates to a patulin magnetic molecular imprinted polymer and a preparation method and application thereof. Background technique [0002] Patulin (PAT) is a fungal secondary metabolite that is highly toxic to the nervous system, tissues and cells of animals. It has potential carcinogenicity, teratogenicity and mutagenicity. Classified as a Group 3 carcinogen. PAT widely exists in apples, hawthorns, plums, bananas, pineapples, peppers, grapes, carrots and other fruits and vegetables and their products, and the main pollutants are apples, apple juice and related products. In order to control the harm of PAT, many countries and institutions have established strict limit standards. Patent CN110156941A uses copolymerization method to prepare Fe 3 o 4 As the material, 4-vinylpyridine was used as the polymer, and trimethylolpropane trimethacrylate or ethylene glycol dimethacrylate was used a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G77/26C08G83/00C08J9/26B01J20/26B01J20/28
CPCC08G77/26C08G83/001C08J9/26B01J20/268B01J20/28009
Inventor 陈贵堂付含王海翔廖声华徐武
Owner CHINA PHARM UNIV