Polysaccharide combined prebiotic granules for regulating brain-gut axis, preparation method and application

Abstract

The invention discloses polysaccharide combined prebiotic granules for regulating a brain-gut axis, a preparation method and application. The polysaccharide combined prebiotic granules comprise raw materials as follows: radix astragali extract, bulbus lilii extract, soluble starch, maltodextrin, sodium citrate, potassium sorbate and xylitol. The preparation method comprises the following steps: the radix astragali extract and the bulbus lilii extract are prepared from radix astragali and bulbus lilii respectively, the soluble starch, maltodextrin, sodium citrate, potassium sorbate and xylitolare added, a soft material is prepared by uniform mixing, and sieving, granulation, drying and granule shaping are carried out to obtain the polysaccharide combined prebiotic granules. The prepared polysaccharide combined prebiotic granules not only have functions of invigorating qi and blood, regulating intestinal flora, inhibiting harmful bacteria and cultivating beneficial bacteria, but also have effects of soothing the nerves, invigorating the brain, improving learning ability and enhancing body immunity, and furthermore, the bulbus lilii and the radix astragali are medicinal and edible traditional Chinese medicines and have both effectiveness of traditional Chinese medicines and safety of food. The polysaccharide combined prebiotic granules have the advantages of being small in dosage, convenient to carry, fast to absorb and stable in curative effect.

Description

Technical field

[0001] The invention relates to the technical field of medicines and foods, and more specifically to a prebiotic particle combined with polysaccharides for regulating the brain-gut axis and a preparation method and application thereof. Background technique

[0002] The information exchange between the brain and the intestine is called the brain-gut axis. The brain-gut axis is a two-way response system that integrates the functions of the brain and the intestine through the central nervous system (CNS) and the enteric nervous system (ENS) . The brain and the intestine communicate bidirectionally through the brain-gut axis. Exogenous information (such as vision, smell, etc.) or internal perceptual information (such as emotion, thinking, etc.) sends out nerve impulses through the central nervous system to affect gastrointestinal perception, movement, and Secretory function, and visceral induction can also affect the central nervous system's perception, emotion and b...

Examples

Embodiment 1

[0059] A kind of prebiotic granules for regulating brain gut axis polysaccharides, comprising 16g of astragalus extract, 16g of lily extract, 54g of soluble starch, 12g of maltodextrin, 0.12g of sodium citrate, 0.08g of potassium sorbate, and xylose 1.8g of alcohol.

[0060] The preparation method of the above-mentioned polysaccharide combination prebiotic particles for regulating the brain-gut axis:

[0061] (1) Crush astragalus and lily through a 40-mesh sieve.

[0062] (2) Astragalus extract extract: using hot water extraction method, 1000g of astragalus powder and drinking water at a material-to-liquid ratio of 1:10 (g / mL), extraction time 3h, extraction temperature 85℃, 6 layers of gauze (21S×32S, latitude and longitude density 28×26) filter, extract twice, combine the extracts, refrigerate at 4℃ for 12h, centrifuge at 3500r / min, 25℃ for 10min, and take the supernatant.

[0063] (3) Lily extract extract: using hot water extraction method, 1000g of lily powder and potable water a...

Embodiment 2

[0068] A combination of prebiotic particles for regulating brain gut axis polysaccharides, comprising 19g astragalus extract extract, 19g lily extract extract, 49g soluble starch, 11g maltodextrin, 0.11g sodium citrate, 0.075g potassium sorbate, and xylose Alcohol 1.815g.

[0069] The preparation method of the above-mentioned polysaccharide combination prebiotic particles for regulating the brain-gut axis:

[0070] (1) Crush astragalus and lily through a 40-mesh sieve.

[0071] (2) Astragalus extract extract: using hot water extraction method, 1000g of astragalus powder and drinking water at a material-to-liquid ratio of 1:12 (g / mL), extraction time of 3h, extraction temperature of 90℃, 8 layers of gauze (21S×32S, latitude and longitude density 28×26) filter, extract twice, combine the extracts, refrigerate at 4℃ for 12h, centrifuge at 3500r / min, 25℃ for 10min, and take the supernatant.

[0072] (3) Lily extract extract: using hot water extraction method, 1000g of lily powder and dri...

Embodiment 3

[0077] A kind of prebiotic granules for regulating brain gut axis polysaccharides, comprising 20g astragalus extract extract, 20g lily extract extract, 48g soluble starch, 10g maltodextrin, 0.1g sodium citrate, 0.07g potassium sorbate, xylose Alcohol 1.83g.

[0078] The preparation method of the above-mentioned polysaccharide combination prebiotic particles for regulating the brain-gut axis:

[0079] (1) Crush astragalus and lily through a 50-mesh sieve.

[0080] (2) Astragalus extract extract: using hot water extraction method, 1000g of astragalus powder and potable water at a material-to-liquid ratio of 1:12 (g / mL), extraction time 3.5h, extraction temperature 90℃, 8 layers Filter with gauze (21S×32S, warp and weft density 28×26), extract twice, combine the extracts, refrigerate at 4°C for 18h, centrifuge at 3800r / min, 25°C for 13min, and take the supernatant.

[0081] (3) Lily extract extract: using hot water extraction method, 1000g of lily powder and drinking water according to ...

Technical field

[0001] The invention relates to the technical field of medicines and foods, and more specifically to a prebiotic particle combined with polysaccharides for regulating the brain-gut axis and a preparation method and application thereof. Background technique

[0002] The information exchange between the brain and the intestine is called the brain-gut axis. The brain-gut axis is a two-way response system that integrates the functions of the brain and the intestine through the central nervous system (CNS) and the enteric nervous system (ENS) . The brain and the intestine communicate bidirectionally through the brain-gut axis. Exogenous information (such as vision, smell, etc.) or internal perceptual information (such as emotion, thinking, etc.) sends out nerve impulses through the central nervous system to affect gastrointestinal perception, movement, and Secretory function, and visceral induction can also affect the central nervous system's perception, emotion and b...

Examples

Embodiment 1

[0059] A kind of prebiotic granules for regulating brain gut axis polysaccharides, comprising 16g of astragalus extract, 16g of lily extract, 54g of soluble starch, 12g of maltodextrin, 0.12g of sodium citrate, 0.08g of potassium sorbate, and xylose 1.8g of alcohol.

[0060] The preparation method of the above-mentioned polysaccharide combination prebiotic particles for regulating the brain-gut axis:

[0061] (1) Crush astragalus and lily through a 40-mesh sieve.

[0062] (2) Astragalus extract extract: using hot water extraction method, 1000g of astragalus powder and drinking water at a material-to-liquid ratio of 1:10 (g / mL), extraction time 3h, extraction temperature 85℃, 6 layers of gauze (21S×32S, latitude and longitude density 28×26) filter, extract twice, combine the extracts, refrigerate at 4℃ for 12h, centrifuge at 3500r / min, 25℃ for 10min, and take the supernatant.

[0063] (3) Lily extract extract: using hot water extraction method, 1000g of lily powder and potable water a...

Embodiment 2

[0068] A combination of prebiotic particles for regulating brain gut axis polysaccharides, comprising 19g astragalus extract extract, 19g lily extract extract, 49g soluble starch, 11g maltodextrin, 0.11g sodium citrate, 0.075g potassium sorbate, and xylose Alcohol 1.815g.

[0069] The preparation method of the above-mentioned polysaccharide combination prebiotic particles for regulating the brain-gut axis:

[0070] (1) Crush astragalus and lily through a 40-mesh sieve.

[0071] (2) Astragalus extract extract: using hot water extraction method, 1000g of astragalus powder and drinking water at a material-to-liquid ratio of 1:12 (g / mL), extraction time of 3h, extraction temperature of 90℃, 8 layers of gauze (21S×32S, latitude and longitude density 28×26) filter, extract twice, combine the extracts, refrigerate at 4℃ for 12h, centrifuge at 3500r / min, 25℃ for 10min, and take the supernatant.

[0072] (3) Lily extract extract: using hot water extraction method, 1000g of lily powder and dri...

Embodiment 3

[0077] A kind of prebiotic granules for regulating brain gut axis polysaccharides, comprising 20g astragalus extract extract, 20g lily extract extract, 48g soluble starch, 10g maltodextrin, 0.1g sodium citrate, 0.07g potassium sorbate, xylose Alcohol 1.83g.

[0078] The preparation method of the above-mentioned polysaccharide combination prebiotic particles for regulating the brain-gut axis:

[0079] (1) Crush astragalus and lily through a 50-mesh sieve.

[0080] (2) Astragalus extract extract: using hot water extraction method, 1000g of astragalus powder and potable water at a material-to-liquid ratio of 1:12 (g / mL), extraction time 3.5h, extraction temperature 90℃, 8 layers Filter with gauze (21S×32S, warp and weft density 28×26), extract twice, combine the extracts, refrigerate at 4°C for 18h, centrifuge at 3800r / min, 25°C for 13min, and take the supernatant.

[0081] (3) Lily extract extract: using hot water extraction method, 1000g of lily powder and drinking water according to ...

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