Polysaccharide combined prebiotic granules for regulating brain-gut axis, preparation method and application

Abstract

The invention discloses polysaccharide combined prebiotic granules for regulating a brain-gut axis, a preparation method and application. The polysaccharide combined prebiotic granules comprise raw materials as follows: radix astragali extract, bulbus lilii extract, soluble starch, maltodextrin, sodium citrate, potassium sorbate and xylitol. The preparation method comprises the following steps: the radix astragali extract and the bulbus lilii extract are prepared from radix astragali and bulbus lilii respectively, the soluble starch, maltodextrin, sodium citrate, potassium sorbate and xylitolare added, a soft material is prepared by uniform mixing, and sieving, granulation, drying and granule shaping are carried out to obtain the polysaccharide combined prebiotic granules. The prepared polysaccharide combined prebiotic granules not only have functions of invigorating qi and blood, regulating intestinal flora, inhibiting harmful bacteria and cultivating beneficial bacteria, but also have effects of soothing the nerves, invigorating the brain, improving learning ability and enhancing body immunity, and furthermore, the bulbus lilii and the radix astragali are medicinal and edible traditional Chinese medicines and have both effectiveness of traditional Chinese medicines and safety of food. The polysaccharide combined prebiotic granules have the advantages of being small in dosage, convenient to carry, fast to absorb and stable in curative effect.

Description

Technical field [0001] The invention relates to the technical field of medicines and foods, and more specifically to a prebiotic particle combined with polysaccharides for regulating the brain-gut axis and a preparation method and application thereof. Background technique [0002] The information exchange between the brain and the intestine is called the brain-gut axis. The brain-gut axis is a two-way response system that integrates the functions of the brain and the intestine through the central nervous system (CNS) and the enteric nervous system (ENS) . The brain and the intestine communicate bidirectionally through the brain-gut axis. Exogenous information (such as vision, smell, etc.) or internal perceptual information (such as emotion, thinking, etc.) sends out nerve impulses through the central nervous system to affect gastrointestinal perception, movement, and Secretory function, and visceral induction can also affect the central nervous system's perception, emotion and b...

AI Technical Summary

Problems solved by technology

[0004] There have been researches at home and abroad on the mechanism of intestinal flora imbalance, insomnia and memory loss, but for the study of intestinal flora improving insomnia and cognitive dysfunction by affecting the brain-gut axis, and improving intestinal flora and There are few studies on drugs to improve insomnia and cognitive dysfunction

The current clinical treatment of intestinal flora imbalance is mainly the use of antibiotics. While killing pathogenic bacteria, antibiotics also affect the normal flora, resulting in flora imbalance. The side effects are large and it is not suitable for long-term use; the drugs for insomnia are mainly sedative and hypnotic Long-term use of such drugs is prone to drug resistance and side effects such as dizziness and drowsiness. In clinical practice, passive treatment methods are mainly used, and active prevention methods are lacking. Due to the strong side effects of psychotropic drugs and antibiotics, traditional Chinese medicine is here promising

[0005] The current marketed drugs for the treatment of intestinal flora imbalance, insomnia and cognitive dysfunction can only treat one of the diseases alone, and there is no drug that can treat the above diseases at the same time, and the marketed drugs have large side effects, and long-term use of these drugs is prone to Drug resistance, sudden withdrawal may cause rebound or withdrawal symptoms

At present, the medicines for calming the nerves and strengthening the brain, such as syrup and oral liquid, have been confirmed by the feedback information of most consumers, and some of them have poor effect, bad taste and inconvenient to carry.

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