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Traditional Chinese medicine composition for soft tissue injury and detection method of composition

A technology for soft tissue damage and detection methods, which can be used in drug combinations, pharmaceutical formulations, and weighing by removing certain components to solve problems such as aplastic anemia or coagulation disorders, allergic reactions, and neutropenia in patients

Pending Publication Date: 2020-02-21
上海图锋医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the foreign therapy has quick effect, it is only a symptomatic treatment, and most of them are local pain point injections or oral non-steroidal drugs, which are likely to cause headache, dizziness, tinnitus, vision loss, drowsiness or insomnia, gastrointestinal reactions, allergic reactions, some Patients also experience side effects such as neutropenia, aplastic anemia, or coagulation disorders

Method used

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  • Traditional Chinese medicine composition for soft tissue injury and detection method of composition
  • Traditional Chinese medicine composition for soft tissue injury and detection method of composition
  • Traditional Chinese medicine composition for soft tissue injury and detection method of composition

Examples

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Effect test

Embodiment 1

[0028] The preparation of embodiment 1 whole powder

[0029] Take 6 parts (6g) of raw gardenia, 6 parts (6g) of raw rhubarb, 2 parts (2g) of raw white peony root, and 1 part (1g) of mirabilite, grind and sieve with a pulverizer to obtain a fine powder.

Embodiment 2

[0030] Example 2 Preparation of water extract

[0031] Take 6 parts (6g) of raw gardenia, 6 parts (6g) of raw rhubarb, 2 parts (2g) of raw white peony, 1 part (1g) of mirabilite, add 8 times of water to reflux to extract, boil for 1 hour, filter, and the dregs Add 6 times of water to reflux for extraction, boil for 1 hour, and filter. The two filtrates were combined, concentrated under reduced pressure to a thick extract, and obtained.

Embodiment 3

[0032] The preparation of embodiment 3 ethanol extract

[0033] Take 6 parts (6g) of raw gardenia, 6 parts (6g) of raw rhubarb, 2 parts (2g) of raw white peony root, 1 part (1g) of mirabilite, add 8 times of 70% ethanol to reflux extraction, boil for 1 hour, filter, Add 6 times of 70% ethanol to the dregs to extract under reflux, boil slightly for 1 hour, and filter. The two filtrates were combined, concentrated under reduced pressure to a thick extract, and obtained.

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Abstract

The invention proposes a traditional Chinese medicine composition for acute soft tissue injury. The traditional Chinese medicine composition is characterized by being prepared from the following raw materials in parts by weight: 1-6 parts of fructus gardeniae, 1-6 parts of radix et rhizoma rhei, 1-3 parts of radix paeoniae alba, and 1-3 parts of sodium sulfafe decahydrate. By performing injury syndrome index evaluation, pathological morphology evaluation, and tissue water content evaluation on model mice, results show that the composition provided by the invention has detumescence, pain-relieving, blood-activating, and blood stasis removing effects on rats with acute sprains; and moreover, by optimizing an HPLC detection method, the method for simultaneously determining the content of seven active ingredients in the traditional Chinese medicine composition is established, and the method is simple and easy to implement, stable and reliable, has relatively-short detection time, and can be used for process research, quality control and novel drug development of the traditional Chinese medicine composition provided by the invention.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for soft tissue injury, a preparation method and a detection method thereof. Background technique [0002] Acute soft tissue injury refers to the injury of limb joints or soft tissue (such as muscle, tendon, ligament, blood vessel, etc.) in the body without fracture, dislocation, skin and muscle damage, etc. The main clinical manifestations are pain and swelling at the injured site, subcutaneous blood stasis, obvious tenderness and limited joint movement, or red, blue, purple and other colors may appear, mostly in the waist, ankles, knees, shoulders, wrists, elbows, hips and other parts . It is mostly due to strenuous exercise or improper posture when bearing heavy weights, or accidental falls, stretching, and excessive twisting, etc., which cause damage to the skin, muscles, and tendons of a certain part, resulting in blocke...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P29/00G01N5/04G01N30/02A61K33/04
CPCA61K33/04A61K36/65A61K36/708A61K36/71A61K36/744A61K2236/333A61K2236/39A61P29/00G01N5/045G01N30/02A61K2300/00
Inventor 肖伟洪燕龙楚世慈张磊王振中吴伟
Owner 上海图锋医药科技有限公司