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Astilbin prepared from folium emglhardtae roxburghianae and preparation method of astilbin

A technology for astilbin and raw materials, which is applied in the field of astilbin and its preparation, can solve the problems of difficulty in realizing industrialized production, low purity of prepared products, complicated technical processes, etc., and achieves improved extraction rate and product purity, low cost, Efficient extraction effect

Inactive Publication Date: 2020-02-28
HUNAN NUSTREETCARAX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, in the extraction technology of Astilbin from Huangqi leaves, there are common problems such as low utilization rate, low purity of the prepared product, complicated technical process, and difficulty in realizing industrial production.

Method used

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  • Astilbin prepared from folium emglhardtae roxburghianae and preparation method of astilbin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The method for preparing astilbin by taking Huang Qiye as raw material comprises the following steps:

[0034] (1) Crushing 500KG of dried leaves of Huangqi leaves into 1-2mm fragments; adding 2500L ethyl acetate to reflux for extraction 3 times, each time for 1.5 hours, and combining the extracts;

[0035] (2) Recover the ethyl acetate in the extract, add 500L of deionized water, drive out the remaining ethyl acetate in the extract, and form the water phase, carry out the first step of crystallization at 5°C, the crystallization time is 8h, and filter The crude product is obtained, with a wet weight of about 70KG;

[0036] (3) Dissolve the crude product with 420L of 50% ethanol, add 2.1KG of activated carbon powder after heating to 65°C in a water bath, stir for 3 minutes and then filter to obtain the filtrate;

[0037] (4) Pass the filtrate through 1m 3 AB-8 resin column, the flow rate is controlled at 1200L / h, and the column is washed with 1500L 50% ethanol at a fl...

Embodiment 2

[0040] The method for preparing astilbin by taking Huang Qiye as raw material comprises the following steps:

[0041] (1) Crush 500KG of dried leaves of Huangqi leaves into 1-2mm pieces; add 3000L ethyl acetate and reflux to extract 3 times, each time for 2 hours, and combine the extracts;

[0042] (2) Recover the ethyl acetate in the extract, add 600L of deionized water, drive out the remaining ethyl acetate in the extract, and form the water phase, and carry out the first step of crystallization at a temperature of 6°C, the crystallization time is 7h, and filter The crude product is obtained, with a wet weight of about 70KG;

[0043] (3) Dissolve the crude product with 500L of 50% ethanol, add 2KG of activated carbon powder after heating to 60°C in a water bath, stir for 5 minutes and then filter to obtain the filtrate;

[0044] (4) Pass the filtrate through 1m 3 D101 resin column, the flow rate is controlled at 1300L / h, and the column is washed with 1500L 50% ethanol at a...

Embodiment 3

[0047] The method for preparing astilbin by taking Huang Qiye as raw material comprises the following steps:

[0048] (1) Crushing 500KG of dry leaves of Huangqi leaves into 1-2mm fragments; adding 2800L ethyl acetate to reflux for extraction 3 times, each time for 2.5 hours, and combining the extracts;

[0049](2) Recover the ethyl acetate in the extract, add 550L of deionized water, drive out the remaining ethyl acetate in the extract, and form a water phase, and carry out the first step of crystallization at a temperature of 7°C, the crystallization time is 6h, and filter The crude product is obtained, with a wet weight of about 70KG;

[0050] (3) Dissolve the crude product in 480L of 50% ethanol, add 2.4KG of activated carbon powder after heating to 62°C in a water bath, stir for 4 minutes and filter to obtain the filtrate;

[0051] (4) Pass the filtrate through 1m 3 AB-8 resin column, the flow rate is controlled at 1500L / h, and the column is washed with 1500L 50% ethano...

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Abstract

The invention discloses astilbin prepared from folium emglhardtae roxburghianae and a preparation method of astilbin. The method includes steps: smashing folium emglhardtae roxburghianae into pieces,subjecting to faint boiling reflex extraction with ethyl acetate, and combining extract liquid; recovering ethyl acetate from the extract liquid, adding deionized water to drive out residual ethyl acetate in the extract liquid, crystallizing for the first time, and filtering to obtain a crude product; dissolving the crude product in ethyl alcohol, adding activated carbon powder, stirring, and filtering to obtain filtrate; enabling the filtrate to flow through a macroporous adsorption resin column, and eluting with ethyl alcohol to obtain outflow; adding ethyl acetate into the outflow, stirring, well mixing, standing, taking supernatant, adding deionized water into the supernatant, and sequentially concentrating, crystallizing for the second time and filtering to obtain crystal, washing, and performing vacuum drying to obtain a product. By adoption of the method, the astilbin extraction rate is remarkably increased while product purity is improved remarkably; low-cost, rapid and efficient astilbin extraction is realized, and applicability to factory mass production is realized.

Description

technical field [0001] The present invention relates to the technical field of extracting active ingredients of natural products, and more specifically, relates to astilbin prepared from the leaves of Huangqi as a raw material and a preparation method thereof. Background technique [0002] Huang Qiye is the dry leaf of Engelhardia roxburghi-ana Wall, which is mainly distributed in Guangdong, Guangxi, Yunnan, Fujian and other places, and is rich in resources. In Guangxi and other places, Huangqi leaves are also known as Arhat tea, which has the effects of clearing heat and detoxifying, promoting body fluids and quenching thirst, and relieving heat, and can eliminate heat, food stagnation, and abdominal pain. Dihydroflavones such as astilbin, taxifolin, and citrus glucoside are the main active ingredients in the leaves of Huangqi, among which astilbin has the highest content. Modern studies have shown that astilbin can lower cholesterol, protect the liver, and have labor pain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
CPCC07H1/08C07H17/07
Inventor 张宝堂郑思佳
Owner HUNAN NUSTREETCARAX
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