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Traditional Chinese medicine composition and preparation thereof for treating metabolic syndromes

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve problems such as large side effects, inconvenient taking, and high price

Active Publication Date: 2020-03-24
李宏 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine mainly uses multiple drugs in combination to control metabolic syndrome, which is expensive, inconvenient to take, and has relatively large side effects; traditional Chinese medicine has not yet developed an effective prescription.
Due to the complexity of metabolic syndrome, there is no specific drug for the treatment of metabolic syndrome in the world so far, and it is of epoch-making significance to carry out clinical research on new drugs for metabolic syndrome

Method used

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  • Traditional Chinese medicine composition and preparation thereof for treating metabolic syndromes
  • Traditional Chinese medicine composition and preparation thereof for treating metabolic syndromes
  • Traditional Chinese medicine composition and preparation thereof for treating metabolic syndromes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Prescription: grams (%, weight ratio): Coptidis 1.5 (7.9), Citrus aurantium 6 (31.6), Pinellia 3 (15.8), Gualou 0, cinnamon 2.5 (13.1), red yeast rice 6 (31.6), take daily The total dosage of medicinal materials is 19 grams, the amount of the obtained extract is 5.58 grams, and the yield is 29.4%.

[0066]Preparation method: Coptidis rhizome, crushed into coarse powder or cut into appropriate size pieces, placed in an extraction tank, added 10 times the amount of 0.5% sulfuric acid, heated and decocted for 3 times for 2 hours each time, filtered, and the extracts were combined. Concentrate under reduced pressure; place the concentrated solution in a precipitation tank, stir, slowly add milk of lime, adjust the pH to 9, let it stand, filter to remove calcium sulfate precipitate; adjust the pH of the filtrate to 1-2 with concentrated hydrochloric acid, add sodium chloride to 10 %, salting out, standing for 24 hours, and suction filtration; the precipitate was washed with ...

Embodiment 2

[0071] Prescription: grams (%, weight ratio): Coptis 4.5 (45), Citrus aurantium 3 (30), pinellia 0%, Trichosanthes 0.5 (5), cinnamon 0.5 (5), red yeast rice 1.5 (15), daily The total dosage of medicinal materials is 10 grams, the amount of the obtained extract is 2.74 grams, and the yield is 27.4%.

[0072] Preparation method: Coptis chinensis medicinal material, the total alkaloid extract was prepared according to the method in Example 1.

[0073] Stir-fry Citrus aurantium, red yeast rice, Trichosanthes mellifera, and cinnamon medicinal materials, prepare according to the prescription amount, mix, place in an alcohol reflux extraction tank, add 10 times and 8 times the amount of 70% ethanol to extract twice, each time for 1 hour, filter, Ethanol was recovered under reduced pressure, concentrated, and dried to obtain the mixed extract of the four Chinese herbal medicines.

[0074] Mix the mixed extracts of Citrus aurantium, Trichosanthes, Cinnamon and Monascus with the extrac...

Embodiment 3

[0077] Prescription: grams (%, weight ratio): Coptidis 4.5 (21.4), Citrus aurantium 4.5 (21.4), pinellia 0%, Trichosanthes 0%, cinnamon 0%, red yeast rice 12 (57.2). The total daily dose of medicinal materials is 21 grams, the amount of the obtained extract is 5.21 grams, and the yield is 24.8%.

[0078] Preparation method: Coptis chinensis medicinal material, the total alkaloid extract was prepared according to the method in Example 1.

[0079] Stir Fructus Citrus Fructus Aurantii and Red Yeast Rice to prepare the mixed extract of two traditional Chinese medicinal materials according to the method of Example 1.

[0080] The Chinese medicine extract composition described in claims 3-9 is obtained by uniformly mixing the mixed extracts of Citrus aurantii Fructus and Monascus Chinese medicine with the extract of Coptidis Rhizoma.

[0081] Content determination results (mg / g): total alkaloids are 43.51 (including berberine 31.83), total flavonoids are 234.38 (including neohesper...

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Abstract

The invention relates to a traditional Chinese medicine composition and a traditional Chinese medicine extract composition for treating metabolic syndromes. The composition consists of the following raw materials (in percentage by weight): 5-80% of rhizoma coptidis, 5-70% of immature orange fruits, 0-60% of pinellia tubers, 0-40% of snakegourd fruits, 2-12% of cinnamon and 10-60% of red yeast rice. The traditional Chinese medicine extract composition consists of the following raw materials (in percentage by weight): 2-30% of a rhizoma coptidis extract, and 70-98% of an extract of a mixture offive traditional Chinese medicines of immature orange fruits, pinellia tubers, red yeast rice, snakegourd fruits and cinnamon. The composition or the traditional Chinese medicine extract composition contains active components (mg / g): 12-122 of total alkaloids, containing 9-89 of berberine; 130-315 of total flavones, containing 80-186 of neohesperidin; and 1-9 of lovastatin. The invention further provides a preparation method and application of the composition.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition and its preparation. Background technique [0002] Metabolic syndrome is a group of clinical conditions that seriously affect human health, with impaired glucose tolerance, hypertension, dyslipidemia, and central obesity as the main content, insulin resistance as the common pathological basis, and the clinical characteristics of a variety of metabolic diseases. syndrome. Currently, 1 / 4-1 / 3 of adults worldwide are affected by metabolic syndrome, and its incidence / prevalence is increasing year by year with the aging population and the prevalence of overweight / obesity. Over the past 20 years, the prevalence of metabolic syndrome in U.S. adults has increased from 21% to 39%. Among adults over 20 years old in my country, the prevalence rates of metabolic syndrome are 14%-18% and 12%-21%, respectively, when diagnosed according t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P3/00A61P3/10A61P3/06
CPCA61K36/718A61K36/752A61K36/8888A61K36/428A61K36/54A61K36/899A61K36/062A61P3/00A61P3/10A61P3/06A61K2236/19A61K2300/00Y02A50/30A61K36/06A61K36/75A61K36/42A61P3/04A61P9/10A61K31/366A61K31/4375A61K31/7048
Inventor 刘喜明李宏
Owner 李宏