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Bioactive scaffold for repairing endometrium and improving fertility

A bioactive, collagen scaffold technology, applied in medical science, prosthesis, etc., can solve the problems of difficult to restore endometrial physiological functions, easy re-adhesion, etc., and achieve the effect of improving fertility and repairing endometrial structure

Active Publication Date: 2020-03-24
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hysteroscopic surgery to remove fibrous scars can restore the shape of the uterine cavity, it is often difficult to restore the physiological function of the endometrium
Moderate and severe intrauterine adhesions are very easy to re-adhesion after surgery, and the rate of post-operative re-adhesion is as high as 62.5%. There is still no effective method to prevent post-operative re-adhesion, resulting in a postoperative pregnancy rate of only 22.5% to 33.3%.

Method used

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  • Bioactive scaffold for repairing endometrium and improving fertility
  • Bioactive scaffold for repairing endometrium and improving fertility
  • Bioactive scaffold for repairing endometrium and improving fertility

Examples

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example 1

[0022] (a) Preparation method of SDF-1α sustained-release particles with recruitment function

[0023] The SDF-1α sustained-release particles are formed by electrostatically complexing negatively charged sulfonated chitosan, slightly positively charged SDF-1α and positively charged polylysine.

[0024] Sulfonated chitosan is prepared by using chitosan as base material and chlorosulfonic acid as sulfonating reagent. First, 9 g of chitosan, 15 mL of dichloroacetic acid and 150 mL of formamide were thoroughly mixed in a beaker to fully swell the chitosan. Afterwards, 150 mL of anhydrous DMF was placed in a 500 mL three-neck flask, stirred in an ice bath, and 30 mL of chlorosulfonic acid was slowly added dropwise therein. Afterwards, the fully swollen chitosan was added into the three-necked flask, and reacted at 60° C. for 2 hours. After the reaction, a small amount of deionized water was added to neutralize the chlorosulfonic acid, the precipitate was centrifuged, and the supe...

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Abstract

The invention relates to a bioactive scaffold for repairing endometrium and improving fertility. The scaffold comprises a substrate and bioactive factors contained by the substrate. Endogenous stem cells are recruited and captured by bioactive factors. The stem cells have pluripotency and play a role in immune regulation and control on a wound surface, thereby effectively promoting endometrial repairing and remarkably increasing the fertility rate. According to the invention, the endogenous stem cell homing means integrated with collection and capturing is employed to repair the damaged endometrium so as to solve problems of intrauterine adhesion, reduced fertility rate and the like caused by a hysteroscope operation, thereby eliminating the potential safety hazards caused by usage of exogenous cells in the traditional repair material. The adopted raw materials have high biocompatibility; the preparation process is simple; exogenous cells are not contained; and the biological safety ishigh.

Description

technical field [0001] The invention relates to the field of tissue engineering scaffolds, in particular to a bioactive scaffold for repairing endometrium and improving fertility. Background technique [0002] Intrauterine adhesions are the second leading cause of secondary infertility in women, mainly caused by trauma, infection, etc. Endometrial damage is accompanied by regeneration and repair disorders, endometrial fibrosis, and ultimately leads to intrauterine adhesions and endometrial atrophy. Endometrial fibrosis, as the main pathological feature of intrauterine adhesions, will not only form fibrous scars and lead to abnormal uterine cavity morphology leading to infertility or miscarriage, but also aggravate the vicious cycle of ischemia and hypoxia leading to aplastic impairment-fibrosis. Although hysteroscopic surgery to remove fibrous scars can restore the shape of the uterine cavity, it is often difficult to restore the physiological function of the endometrium. M...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/22A61L27/20
CPCA61L27/20A61L27/227A61L27/24C08L5/08
Inventor 马列张松英郑晓闻辛廖冰
Owner ZHEJIANG UNIV
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