Bioactive scaffold for repairing endometrium and improving fertility

Abstract

The invention relates to a bioactive scaffold for repairing endometrium and improving fertility. The scaffold comprises a substrate and bioactive factors contained by the substrate. Endogenous stem cells are recruited and captured by bioactive factors. The stem cells have pluripotency and play a role in immune regulation and control on a wound surface, thereby effectively promoting endometrial repairing and remarkably increasing the fertility rate. According to the invention, the endogenous stem cell homing means integrated with collection and capturing is employed to repair the damaged endometrium so as to solve problems of intrauterine adhesion, reduced fertility rate and the like caused by a hysteroscope operation, thereby eliminating the potential safety hazards caused by usage of exogenous cells in the traditional repair material. The adopted raw materials have high biocompatibility; the preparation process is simple; exogenous cells are not contained; and the biological safety ishigh.

Description

technical field [0001] The invention relates to the field of tissue engineering scaffolds, in particular to a bioactive scaffold for repairing endometrium and improving fertility. Background technique [0002] Intrauterine adhesions are the second leading cause of secondary infertility in women, mainly caused by trauma, infection, etc. Endometrial damage is accompanied by regeneration and repair disorders, endometrial fibrosis, and ultimately leads to intrauterine adhesions and endometrial atrophy. Endometrial fibrosis, as the main pathological feature of intrauterine adhesions, will not only form fibrous scars and lead to abnormal uterine cavity morphology leading to infertility or miscarriage, but also aggravate the vicious cycle of ischemia and hypoxia leading to aplastic impairment-fibrosis. Although hysteroscopic surgery to remove fibrous scars can restore the shape of the uterine cavity, it is often difficult to restore the physiological function of the endometrium. M...

AI Technical Summary

Problems solved by technology

Although hysteroscopic surgery to remove fibrous scars can restore the shape of the uterine cavity, it is often difficult to restore the physiological function of the endometrium

Moderate and severe intrauterine adhesions are very easy to re-adhesion after surgery, and the rate of post-operative re-adhesion is as high as 62.5%. There is still no effective method to prevent post-operative re-adhesion, resulting in a postoperative pregnancy rate of only 22.5% to 33.3%.

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