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Intraocular lens with divisionally modified rear surface and preparation method of intraocular lens

An intraocular lens and posterior surface technology, which is applied in the direction of intraocular lens, eye implants, etc., to achieve the effect of inhibiting migration and transdifferentiation, reducing the incidence of posterior cataract, and low cost

Inactive Publication Date: 2020-03-27
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the above two invention patent applications have achieved partial results in inhibiting post-cataract, they only act on a part of the pathophysiological process of the body's spontaneous repair response after cataract surgery, such as lens epithelial cell proliferation, migration, or transdifferentiation. Therefore, it can only partially inhibit the occurrence of post-cataract

Method used

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  • Intraocular lens with divisionally modified rear surface and preparation method of intraocular lens
  • Intraocular lens with divisionally modified rear surface and preparation method of intraocular lens
  • Intraocular lens with divisionally modified rear surface and preparation method of intraocular lens

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Embodiment 1

[0042] Such as figure 1 As shown, the intraocular lens (IOL) with partitioned posterior surface modification provided in the embodiment includes an optical part and a loop. The central area of ​​the posterior surface of the optical part is a TGF-β2 antibody multilayer nano-film, and the remaining peripheral areas are high-viscosity interfaces.

[0043] After cataract surgery, the residual lens epithelial cells (HLE, long arrow) proliferate and secrete transforming growth factor-β2 (TGF-β2, short arrow), which can promote the migration and transdifferentiation of HLE on the surface of the posterior capsule, thereby causing later hair Sexual cataract. The high-viscosity interface in the peripheral area of ​​the IOL is tightly combined with the anterior and posterior capsules to produce a mechanical barrier effect and inhibit the migration of HLE to the surface of the posterior capsule. The TGF-β2 antibody deposited on the posterior surface of the IOL (dashed arrow) can capture TGF-...

Embodiment 2

[0057] Taking dielectric barrier discharge plasma pretreatment under sub-atmospheric pressure and linear growth of electrostatic layer-by-layer self-assembly technology for surface modification of hydrophobic acrylate IOL as an example, the preparation process of the intraocular lens with rear surface partition modification is described as follows:

[0058] (1) Plasma pretreatment: Place the dry hydrophobic acrylate intraocular lens on the central area of ​​the quartz glass plate below, set the plasma treatment chamber pressure to 2000Pa, adjust the atmosphere to air mode, and set the current frequency to 10kHz and the input voltage Discharge for 1 min under 220V and 75W power, then shake and rinse with ultrapure water for 5 hours, and finally blow dry with nitrogen and store in a dry place at room temperature;

[0059] (2) TGF-β in the central area of ​​the posterior surface of IOL 2 The construction of antibody nano multilayer film includes the following steps:

[0060] (2-1) Place...

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Abstract

The invention discloses an intraocular lens with a divisionally modified rear surface and a preparation method of the intraocular lens. The intraocular lens comprises an optical part and a loop, the central area of the rear surface of the optical part is a TGF-[beta]2 antibody multilayer nanometer film, the rest peripheral area is a high-viscosity interface, the thickness of the TGF-[beta]2 antibody multilayer nanometer film is 6.35-7.85 nm, and when the intraocular lens is implanted into an eye for more than 2 weeks, the intraocular lens can be tightly attached to the lens capsule through thehigh-viscosity interface. A peripheral region high-viscosity interface and a central region TGF-[beta]2 antibody multilayer nanometer film are constructed on the rear surface of the artificial lens to realize divisional modification of the rear surface of the artificial lens, and migration and transdifferentiation of lens epithelial cells are inhibited through dual mechanisms, so that the occurrence rate of posterior cataract is remarkably reduced.

Description

Technical field [0001] The invention belongs to the field of medical implant materials, and specifically relates to an intraocular lens with partitioned modification of the posterior surface and a preparation method thereof. Background technique [0002] Cataract is currently the most common reversible blindness in the clinic. The use of phacoemulsification combined with intraocular lens implantation can quickly restore vision. However, about 30%-50% of patients will experience opacity of the posterior lens capsule (ie, post-cataract) within 2-5 years after surgery, which causes the vision to drop again. The proliferation, migration and transdifferentiation of residual lens cells after cataract surgery are the main causes of posterior capsule opacity. [0003] At present, the surface modification of the intraocular lens to increase its biocompatibility or the use of the intraocular lens as a drug slow-release carrier has become the main means to inhibit the subsequent cataract. F...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/16
CPCA61F2/1613
Inventor 孙传宾姚克
Owner ZHEJIANG UNIV
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