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Developable embolic microsphere and preparation method thereof

A technology for embolizing microspheres and microspheres, which is applied in medical science, surgery, surgical adhesives, etc., can solve the problems of no autoradiography, long time-consuming, inconvenient mass production, etc., to improve biocompatibility, production The effect of low cost and easy mass production

Active Publication Date: 2020-03-27
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The existing process for preparing β-TCP microspheres is cumbersome, and the preparation process requires sintering or secondary crosslinking, which takes a long time, is not convenient for mass production, and needs to be used in combination with a commercial developer, without self-development effect

Method used

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  • Developable embolic microsphere and preparation method thereof
  • Developable embolic microsphere and preparation method thereof
  • Developable embolic microsphere and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0035] A developable embolic microsphere, prepared by polyvinyl alcohol (PVA), β-tricalcium phosphate (TCP), nanobismuth and glutaraldehyde by reverse phase suspension polymerization technique, the preparation flow chart is as follows figure 1 Described, concrete preparation process is as follows:

[0036] S1. Dissolve 2g of polyvinyl alcohol in 18g of pure water to obtain 20mL of 10% polyvinyl alcohol solution, then add 0.25g of β-tricalcium phosphate to the solution, that is, mix and disperse according to the ratio of PVA:TCP=8:1 , after stirring for 1h, add 20mg of Bi nanoparticles, 400r / min;

[0037] S2. Add 200 μL of concentrated hydrochloric acid to the polyvinyl alcohol solution containing TCP / Bi in step S1 for acidification;

[0038] S3. Add 0.6g of span-80 into a beaker containing 30mL of liquid paraffin, place in an oil bath at 55°C, rotate at 400r / min, and stir magnetically.

[0039] S4. Add 80 μL of 50% glutaraldehyde (glutaraldehyde density is about 1.06 g / mL, 8...

Embodiment 2

[0043] A developable embolic microsphere, the preparation process of which is the same as in Example 1, except that the mass ratio of PVA:TCP in step S1 is 10:2, and other steps are the same as in Example 1.

Embodiment 3

[0045] A developable embolic microsphere, the preparation process is the same as in Example 1, except that the mass ratio of PVA:TCP in step S1 is 6:1, and 0.5 g of span-80 in step S3 is placed in a 60°C oil bath , other steps are identical with embodiment 1.

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Abstract

The invention discloses a developable embolic microsphere and a preparation method thereof. The embolic microsphere is prepared from polyvinyl alcohol, beta-tricalcium phosphate, nano bismuth and glutaraldehyde through a reversed phase suspension polymerization technology; a continuous phase is liquid paraffin and a surfactant; and a dispersion phase is the polyvinyl alcohol, the beta-tricalcium phosphate, the nano bismuth and the glutaraldehyde, and the using amount ratio of the polyvinyl alcohol, the beta-tricalcium phosphate, the nano bismuth and the glutaraldehyde is, by weight, 10 : 1-2 :0.1-0.8 : 0.7-1.25. Through the introduction of bismuth into the embolic microsphere, the accuracy of the real-time imaging of interventional embolization treatment can be enhanced, and a novel design scheme can be provided for the imageable embolic microsphere; the bismuth ions can be discharged in bodies, and compared with iodine, the bismuth is safer; the embolic microsphere is simple in technology, short in preparation time and easy in mass production realizing; and through the addition of a TCP material, the biocompatibility of the microsphere can be enhanced.

Description

technical field [0001] The invention relates to the medical technical field of nuclear magnetic resonance contrast agents, and more specifically, to a developable embolic microsphere and a preparation method thereof. Background technique [0002] At present, in interventional embolization, commercial contrast agents such as iohexol and iodixanol are widely used clinically. These contrast agents are mixed with embolic microspheres and then injected into the human body. Due to the presence of iodine element, the microspheres have better imaging capabilities. However, when these commercial contrast agents are mixed with embolic microspheres, the two phases may separate, and the imaging results cannot accurately represent the actual position of embolic microspheres, which brings certain misdiagnosis factors and unfavorable factors to the diagnosis. [0003] If the embolic microsphere itself has the function of self-imaging, then the problem of two-phase separation of the develo...

Claims

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Application Information

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IPC IPC(8): A61L24/06A61L24/00A61L24/02
CPCA61L24/001A61L24/02A61L24/06C08L29/04
Inventor 张超刘景龄杨越雄张阳黄丹
Owner SUN YAT SEN UNIV
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