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Glaucoma drainage valve with antiproliferative drug sustained release coating grafted on surface and preparation method thereof

A technology of surface grafting and glaucoma, which is applied in directions such as ophthalmic surgery to achieve the effects of easy disinfection, simple preparation process and low cost

Inactive Publication Date: 2020-03-31
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The glaucoma aqueous humor drainage device can drain the intraocular aqueous humor, but the glaucoma aqueous humor drainage device still cannot avoid the scarring of the filtering bleb after implantation

Method used

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  • Glaucoma drainage valve with antiproliferative drug sustained release coating grafted on surface and preparation method thereof
  • Glaucoma drainage valve with antiproliferative drug sustained release coating grafted on surface and preparation method thereof
  • Glaucoma drainage valve with antiproliferative drug sustained release coating grafted on surface and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0036] In this embodiment, glow discharge plasma equipment under subatmospheric pressure is used for glow discharge plasma treatment under subatmospheric pressure, and the antiproliferative drug is paclitaxel.

[0037] Graft anti-proliferative drug slow-release coating on the surface of glaucoma drainage valve by plasma grafting technology, the specific steps include:

[0038] Step 1, plasma pretreatment: the glaucoma drainage valve with a clean and dry surface is placed in the central area of ​​the surface of the quartz glass plate used as the stage, and the surface of the glaucoma drainage valve is subjected to glow discharge plasma pretreatment under subatmospheric pressure for the first time, The pretreatment conditions are as follows: the air pressure in the plasma treatment chamber is set to 2000Pa, the atmosphere is adjusted to air mode, and the discharge treatment is performed for 1min at a current frequency of 10kHz, an input voltage of 220V, and a power of 75W. After ...

Embodiment 2

[0046] In this embodiment, dielectric barrier discharge plasma equipment under atmospheric pressure is used to conduct dielectric barrier discharge plasma treatment under atmospheric pressure, and the anti-proliferative drug is paclitaxel.

[0047] Graft anti-proliferative drug slow-release coating on the surface of glaucoma drainage valve by plasma grafting technology, the specific steps include:

[0048] Step 1, plasma pretreatment: the glaucoma drainage valve with a clean and dry surface is placed in the central area of ​​the surface of the quartz glass plate used as the stage, and the surface of the glaucoma drainage valve is subjected to glow discharge plasma pretreatment under atmospheric pressure for the first time. The treatment conditions are: at 0.4m 3 After passing argon gas at a flow rate of / h for 1 min, discharge treatment for 1 min at a current frequency of 10 kHz and an input voltage of 35 V. After the pretreatment, the surface chemical activity of the glaucom...

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Abstract

The invention discloses a glaucoma drainage valve with an antiproliferative drug sustained release coating grafted on a surface and a preparation method thereof. The preparation method of the glaucomadrainage valve with the antiproliferative drug sustained release coating grafted on the surface comprises the following steps: (1) performing first plasma pretreatment on a surface of a glaucoma drainage valve so as to activate chemical activity of the surface of the glaucoma drainage valve; (2) washing the glaucoma drainage valve subjected to the surface chemical activity activation, and soakingthe glaucoma drainage valve in an antiproliferative drug sustained release solution; and (3) performing second plasma treatment on the surface of the glaucoma drainage valve subjected to the soakingwith the antiproliferative drug sustained release solution, and carrying out rinsing and drying so as to obtain the glaucoma drainage valve with the antiproliferative drug sustained release coating grafted on the surface. The preparation method of the glaucoma drainage valve with the antiproliferative drug sustained release coating grafted on the surface is easy to operate; and the prepared glaucoma drainage valve with the antiproliferative drug sustained release coating grafted on the surface is capable of inhibiting proliferation, migration and extracellular matrix secretion of Tenon sac fibroblasts, thereby significantly reducing incidence of cicatrization of filtering bleb after glaucoma drainage.

Description

technical field [0001] The invention relates to the technical field of medical implant materials and device surface modification, in particular to a glaucoma drainage valve grafted with anti-proliferative drugs on the surface and a preparation method thereof. Background technique [0002] Glaucoma is one of the main causes of irreversible blindness at home and abroad, and glaucoma drainage valve implantation is an effective treatment for refractory glaucoma. The glaucoma drainage valve is a surgical device used to treat glaucoma. It uses a silicone tube to drain the aqueous humor to the disc installed behind the eyeball to form a reservoir of aqueous humor. Finally, the aqueous humor diffuses to the tissue at the back of the eyeball and Absorbed by capillaries and lymphatic vessels, this device is commonly used in the treatment of neovascular glaucoma. [0003] Although glaucoma drainage valve implantation can effectively treat refractory glaucoma, there are safety hazards ...

Claims

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Application Information

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IPC IPC(8): A61F9/007
CPCA61F9/00736
Inventor 孙传宾
Owner ZHEJIANG UNIV
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