A kind of high-efficiency detection mercury ion probe, preparation method and application

A mercury ion and fluorescent probe technology, applied in the field of fluorescent probes, can solve the problems of in-situ, real-time, online monitoring of mercury ions, poor selectivity, complex synthesis, etc., and achieve rapid qualitative and quantitative detection with high selectivity , Strong anti-interference ability

Active Publication Date: 2022-05-10
UNIV OF JINAN
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, the reported methods for detecting mercury ions include spectrophotometric colorimetry, high performance liquid chromatography, chemiluminescence analysis, and fluorescent probe analysis, among which fluorescent probes are highly selective, ultra-sensitive, and synthetic The unique advantages such as simplicity have become the focus of researchers. The reported fluorescent probe analysis methods still have certain defects, including low sensitivity, poor selectivity, poor water solubility, complex synthesis, etc., and cannot achieve in situ, real-time, online. Requirements for monitoring mercury ions

Method used

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  • A kind of high-efficiency detection mercury ion probe, preparation method and application
  • A kind of high-efficiency detection mercury ion probe, preparation method and application
  • A kind of high-efficiency detection mercury ion probe, preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: step a product (VII) is synthesized

[0044] The reaction scheme is as follows:

[0045]

[0046] Add 3865mg (20.0mmol) 4-(diethylamino) salicylaldehyde, 3383.64mg (26mmol) ethyl acetoacetate and piperazine catalyst into absolute ethanol, react at 80°C for 12h, and separate the crude product by chromatographic column to obtain The pure product is 3734mg, and the yield is 73%.

Embodiment 2

[0047] Embodiment 2: step b product (VIII) is synthesized

[0048] The reaction scheme is as follows:

[0049]

[0050] Dissolve 3630.2mg (14mmol) of the compound of formula (VII) and 2481.3mg (14mmol) of 4-(dimethylamino)-2,3-dimethylbenzaldehyde and piperazine in ethanol, and heat to 80°C for reflux reaction for 12h . The product was separated by chromatographic column to obtain 3225 mg of pure product with a yield of 59%.

Embodiment 3

[0051] Embodiment 3: step c product (II) is synthesized

[0052] The reaction scheme is as follows:

[0053]

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PUM

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Abstract

The invention relates to a high-efficiency mercury ion detection probe, a preparation method and an application. Specifically, the probe of the present invention is a class of fluorescent probes based on coumarin compounds as fluorophores and thiols as recognition receptors, which can achieve high selectivity to mercury ions, ultrasensitive analysis, and determination of mercury in samples. The concentration of ions; this type of probe can achieve at least one of the following technical effects: high selectivity, strong anti-interference ability, fast response, convenient qualitative analysis, strong anti-interference ability, high sensitivity, and wide detection range.

Description

technical field [0001] The invention belongs to the field of fluorescent probes, and specifically relates to fluorescent probes using coumarin compounds as fluorophores and thiols as receptors, which can achieve high selectivity and ultra-sensitive analysis of mercury ions, or can measure mercury ions in samples concentration; the present invention also provides a method for preparing the fluorescent probe. Background technique [0002] As a metal element with severe physiological toxicity, mercury is released into the environment due to gold mining, petroleum refining and fossil fuels, which has attracted more and more attention. Even at very low concentrations, mercury can still accumulate in the human body through the food chain, damage enzymes and proteins in the body, and cause various diseases, such as: brain damage, kidney damage, behavioral imbalance and cognitive impairment Wait. Mercury poisoning will have an extremely bad impact on the whole society. Mercury is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/16C09K11/06G01N21/64
CPCC07D311/16C09K11/06G01N21/6428G01N21/643C09K2211/1088C09K2211/1007
Inventor 虞亚敏柳彩云高娜朱宝存
Owner UNIV OF JINAN
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