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Magnetic nanoparticle temperature calculation method based on low-field magnetic resonance T2 relaxation

A magnetic nanoparticle and magnetic nanoparticle technology, applied in the field of magnetic nanomaterial testing, can solve the problems of poor linearity, difficult imaging, and low temperature measurement accuracy, and achieve the effect of high-precision temperature measurement

Active Publication Date: 2020-04-10
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

[0005] Aiming at the problems of low temperature measurement accuracy, poor linearity and difficult imaging in existing magnetic temperature imaging in the prior art, the present invention provides a low-field magnetic resonance T 2 Relaxation magnetic nanoparticle temperature calculation method, which aims to use magnetic nanoparticles as T 2 Contrast agent, under a low-field (magnetic field strength ≤ 0.5T) magnetic resonance system, by measuring T 2 Relaxation time, the temperature can be calculated to achieve high-sensitivity temperature measurement

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  • Magnetic nanoparticle temperature calculation method based on low-field magnetic resonance T2 relaxation
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  • Magnetic nanoparticle temperature calculation method based on low-field magnetic resonance T2 relaxation

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Embodiment

[0057] 1. Obtainment of magnetic field dependence of candidate magnetic nanoparticles and their induced magnetization temperature sensitivity.

[0058] The SHP series magnetic nanoparticle reagents SHP-05, SHP-10 and SHP-20 (Ocean NanoTech Company) with nominal core particle diameters of 5nm, 10nm and 20nm were selected, all based on Fe 3 o 4 It is a magnetic core, and the surface of the magnetic core is coated with a single layer of oleic acid and a single layer of amphiphilic polymer, so it has good water solubility and monodispersity.

[0059] Take a certain amount of the above-mentioned candidate magnetic nanoparticle reagents to fill small centrifuge tubes, seal them up, and then use the SQUID-MPMS-XL7 (Quantum Design, USA) magnetic measurement system to set the sample temperature at 290K, 300K, 305K, 310K and 320K respectively. , measure its M-H magnetization curve, where the excitation magnetic field ranges from 0 Oe to 15000 Oe. The M-H magnetization curves of magnet...

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Abstract

The invention discloses a magnetic nanoparticle temperature calculation method based on low-field magnetic resonance T2 relaxation, and belongs to the technical field of magnetic nano material testing. Magnetic nanoparticles capable of serving as a T2 contrast agent serve as a medium for temperature-to-magnetic field conversion, and then the temperature characteristic of T2 relaxation time is established. The magnetic nanoparticles have good temperature sensitivity, so that the obtained T2 relaxation time has a linear relationship with the temperature, the temperature change is reflected by measuring the T2 relaxation time, and high-precision temperature measurement is realized. The M-H magnetization curves of the magnetic nanoparticles are measured at different temperatures, the magneticfield dependence of the induction magnetization intensity temperature sensitivity of the magnetic nanoparticles is solved, the magnetic nanoparticles matched with the main magnetic field of the low-field magnetic resonance instrument are preferably selected according to the magnetic field dependence, the induction magnetization intensity temperature sensitivity of the magnetic nanoparticles is maximized, and high-precision temperature measurement is realized.

Description

technical field [0001] The invention belongs to the technical field of magnetic nanomaterial testing, and more specifically, relates to a low-field magnetic resonance T 2 Calculation method for relaxation temperature of magnetic nanoparticles. Background technique [0002] Magnetic temperature measurement technology can penetrate the surface and directly detect the internal temperature of objects. It is a technological frontier with broad prospects in the fields of life, materials and microelectronics. Magnetic temperature measurement is expected to open a new field of internal temperature measurement (monitoring) of complex heat transfer structures or complex heat transfer processes. However, since Pierre Curie proposed the idea of ​​magnetic temperature measurement a hundred years ago, there has been no breakthrough in the temperature measurement method and device realized by magnetic methods. According to Curie's paramagnetic theorem, the magnetic susceptibility of para...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01K7/36
CPCG01K7/36
Inventor 刘文中张亚鹏
Owner HUAZHONG UNIV OF SCI & TECH
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