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Preparation method of refined egg yolk antibody effervescent tablet for infectious bursal disease

A technology of egg yolk antibody and effervescent tablets, which is applied in the field of preparation of refined egg yolk antibody effervescent tablets for chicken bursal disease, can solve the problems of high stress and poor effect of egg yolk antibody injection, and achieve stress reduction, risk reduction, Improves the effect of the overall immune effect

Inactive Publication Date: 2020-04-14
TIANJIN HLINTE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Another object of the present invention is to solve the drawbacks of the prior art that the yolk antibody injection is stressful and the effect is poor

Method used

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  • Preparation method of refined egg yolk antibody effervescent tablet for infectious bursal disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of chicken bursal disease refined yolk antibody effervescent tablet, the steps of the preparation method are:

[0028] (1) Take 23-week-old healthy laying hens that have not been immunized, and immunize them with chicken infectious bursa oil emulsion inactivated vaccine 3 times. The immunization interval is 10 days, and the dosage is 1ml / bird / time, and the serum is detected Collect highly immune eggs when the antibody titer reaches 1:256;

[0029] (2) Take the high-free eggs obtained in step (1), rinse them with clean water, immerse them in 0.1% bromogeramine aqueous solution for disinfection for 15 minutes, take them out and dry them in the air, and then sterilize them with ethylene oxide aerosol for 30 minutes, then send them into egg whites and egg yolks for separation Machine separation to obtain egg yolk, stirring to obtain egg yolk homogenate;

[0030] (3) Add 1.5 times the volume of normal saline and 0.1% n-octanoic acid to the egg yolk homo...

Embodiment 2

[0036] A preparation method of chicken bursal disease refined egg yolk antibody effervescent tablet without probiotics, the steps of the preparation method are:

[0037] (1) Take 23-week-old healthy laying hens that have not been immunized, and immunize them with chicken infectious bursa oil emulsion inactivated vaccine 3 times. The immunization interval is 10 days, and the dosage is 1ml / bird / time, and the serum is detected Collect highly immune eggs when the antibody titer reaches 1:256;

[0038] (2) Take the high-free eggs obtained in step (1), rinse them with clean water, immerse them in 0.1% bromogeramine aqueous solution for disinfection for 15 minutes, take them out and dry them in the air, and then sterilize them with ethylene oxide aerosol for 30 minutes, then send them into egg whites and egg yolks for separation Machine separation to obtain egg yolk, stirring to obtain egg yolk homogenate;

[0039] (3) Add 1.5 times the volume of normal saline and 0.1% n-octanoic ac...

Embodiment 3

[0044] A preparation method of chicken infectious bursal disease egg yolk antibody effervescent tablet without lyoprotectant, the steps of the preparation method are:

[0045] (1) Take 23-week-old healthy laying hens that have not been immunized, and immunize them with chicken infectious bursa oil emulsion inactivated vaccine 3 times. The immunization interval is 10 days, and the dosage is 1ml / bird / time, and the serum is detected Collect highly immune eggs when the antibody titer reaches 1:256;

[0046] (2) Take the high-free eggs obtained in step (1), rinse them with clean water, immerse them in 0.1% bromogeramine aqueous solution for disinfection for 15 minutes, take them out and dry them in the air, and then sterilize them with ethylene oxide aerosol for 30 minutes, then send them into egg whites and egg yolks for separation Machine separation to obtain egg yolk, stirring to obtain egg yolk homogenate;

[0047] (3) Add 1.5 times the volume of normal saline and 0.1% n-octan...

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Abstract

The invention provides a preparation method of a refined egg yolk antibody effervescent tablet for infectious bursal disease. The method includes: utilizing an infectious bursal disease oil emulsion inactivated vaccine to immunize healthy high-yield laying hens, collecting hyperimmune eggs, and extracting egg yolk antibody; and attaching probiotics to the antibody, and adding a freeze-drying protective agent and an effervescent material to prepare the product. The method innovatively designs a new dosage form of the infectious bursal disease egg yolk antibody, and enriches the new approach forinfectious bursal disease control. The method provided by the invention has the characteristics of low cost, high antibody titer, convenient use and high biological safety, and the treatment effect of the obtained egg yolk antibody is effectively guaranteed.

Description

technical field [0001] The invention belongs to the technical field of veterinary biological products, and in particular relates to a method for preparing chicken bursal disease refined egg yolk antibody effervescent tablets. Background technique [0002] Intensive farming of poultry has brought unprecedented rapid development, but also caused the rapid occurrence of highly contagious infectious diseases such as chicken infectious bursal disease, causing the disease virus to proliferate mainly in the lymphocytes of the bursa, and to other The immune organs cause varying degrees of damage, which eventually leads to atrophy of the bursa of Fabricius in chickens and causes immunosuppression in chickens. The disease has no obvious seasonality, it can occur all year round, and the incidence rate can reach more than 90%. Clinically, it can cause symptoms such as weight loss, slow growth, and skeletal muscle hemorrhage. Once the epidemic occurs, it will spread quickly and the morta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/42A61K9/20A61P31/14C07K16/10C07K16/02C07K1/34C12N1/20C12R1/01C12R1/125
CPCA61K9/0007A61K9/2013A61K9/2018A61K9/2031A61K9/2068A61K9/2095A61K2039/505A61K2039/542A61K2039/55A61P31/14C07K16/02C07K16/10C12N1/20C12N2720/10034
Inventor 安同伟陈庆忠李迎梅
Owner TIANJIN HLINTE BIOTECH CO LTD
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