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Application of vaccinium dunalianum tea or extract thereof in preparation of medicine for preventing and/or treating type 2 diabetes mellitus

A technology for type 2 diabetes and extracts, applied in the field of medicine, can solve the problem that there is no patent literature report in the research on type 2 diabetes, and achieve the effect of high safety

Inactive Publication Date: 2020-04-21
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, at present, there are no patent literature reports on the research on the prevention and treatment of type 2 diabetes by Quezui tea extract at home and abroad.

Method used

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  • Application of vaccinium dunalianum tea or extract thereof in preparation of medicine for preventing and/or treating type 2 diabetes mellitus
  • Application of vaccinium dunalianum tea or extract thereof in preparation of medicine for preventing and/or treating type 2 diabetes mellitus
  • Application of vaccinium dunalianum tea or extract thereof in preparation of medicine for preventing and/or treating type 2 diabetes mellitus

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preparation example Construction

[0024] The extract of the present invention is preferably methanol extract of Sparrow's mouth tea, and the preparation method of the extract preferably includes: mixing Sparrow's beak tea with methanol aqueous solution, ultrasonic extraction, filtration, concentration and freeze-drying. The mass volume ratio of sparrow mouth tea and methanol aqueous solution in the present invention is preferably 1g:10mL; the volume concentration of methanol in the methanol aqueous solution is preferably 60-80%, more preferably 70%. The ultrasonic power of the ultrasonic extraction in the present invention is preferably 70w, the frequency is 50Hz, and the voltage is 220V; the extraction time is preferably 30min. In the present invention, during the ultrasonic extraction, especially after the filtration, it is preferable to further perform the ultrasonic extraction and filtration on the filtered filter residue for 1-2 times, and mix the filtrate. The present invention has no special limitation ...

Embodiment 1

[0029] Preparation of Sparrow's Bill Tea Extract

[0030] Quezui tea was collected from Chuxiong Yi Autonomous Prefecture, Yunnan Province. After natural drying, it was powdered to obtain a sample of Quezui tea; 100g of Quezui tea sample was weighed, and the ratio of solid to liquid was g:mL=1:10. % methanol aqueous solution at 25° C. for 30 min with ultrasonic assistance, filtered, repeated extraction of the filter residue twice, combined filtrates, concentrated and freeze-dried to obtain Quezui tea extract.

Embodiment 2

[0032] Effects of sparrow mouth tea polyphenol extract and polysaccharide extract on blood sugar regulation and intestinal flora in hyperglycemic rats

[0033] 1. Extract polyphenols and polysaccharides, the specific method is as follows: Weigh 3kg of Quezui tea, add an appropriate amount of 70% methanol water, ultrasonicate for 30min, ultrasonic power 70W, frequency 50Hz, then filter, add appropriate amount of 70% methanol water to the filter residue , continue ultrasonic extraction, after repeating three times, combine the filtrate, concentrate under reduced pressure, the concentrated solution is adsorbed with D101 macroporous resin, and the macroporous resin is eluted with pure water and methanol respectively, and the pure water eluent is concentrated under reduced pressure, 80% ethanol aqueous solution was added to the concentrated solution overnight, and the obtained precipitate was crude polysaccharide 1. The methanol eluate was concentrated under reduced pressure, and t...

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Abstract

The invention provides application of vaccinium dunalianum tea or an extract thereof in preparation of a medicine for preventing and / or treating type 2 diabetes mellitus, and relates to the technicalfield of medicines. Vaccinium dunalianum tea is vaccinium plant found in south of China, the raw materials are convenient to collect, and the cost is low; toxicological experiments show that the vaccinium dunalianum tea extract is non-toxic and high in safety at a relatively low concentration; the technological process of extraction and preparation is simple, new medical application is explored for the vaccinium dunalianum tea extract, and a new research field is developed; in the embodiment of the invention, the vaccinium dunalianum tea extract can effectively inhibit the activity of MPO in pancreatic tissues of type 2 diabetes mellitus model mice at a relatively low dosage, and the effect of reducing the blood sugar of rats is obvious; the raw material comes from natural product, so thatthe safety is high; the vaccinium dunalianum extract is suitable for industrial production and market popularization and application.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of sparrow beak tea or its extract in the preparation of drugs for preventing and / or treating type 2 diabetes. Background technique [0002] Type 2 diabetes (diabetes mellitus, type 2) is also known as non-insulin-dependent diabetes, and the incidence of type 2 diabetes accounts for more than 90% of the total number of diabetic patients. Most of the patients with type 2 diabetes are middle-aged and elderly people over 30 years old. Unlike type 1 diabetes, type 2 diabetes is caused by the abnormal function of pancreatic beta cells in the body and insufficient insulin secretion. The pathogenesis of type 2 diabetes can be divided into three stages. The first stage is the stage of glucose tolerance, mainly when insulin begins to resist; the second stage is the stage of abnormal glucose tolerance, also known as prediabetes. In the abnormal stage, insulin ...

Claims

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Application Information

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IPC IPC(8): A61K36/45A61P3/10
CPCA61K36/45A61P3/10
Inventor 程桂广李梦成曹建新张金科赵天瑞蔡圣宝
Owner KUNMING UNIV OF SCI & TECH
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