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Medical application of pulsatilla saponin B4 in resisting acute gouty arthritis

A technology of Pulsatilla saponin and acute gout, which is applied in the field of medicine and can solve problems such as acute gouty arthritis that has not yet been seen with Pulsatilla saponin B4

Pending Publication Date: 2020-04-28
刘琦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there has been no report on the use of Pulsatilla saponin B4 for the treatment of acute gouty arthritis

Method used

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  • Medical application of pulsatilla saponin B4 in resisting acute gouty arthritis
  • Medical application of pulsatilla saponin B4 in resisting acute gouty arthritis
  • Medical application of pulsatilla saponin B4 in resisting acute gouty arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preliminary observation of the effect of Pulsatilla saponin B4 on sodium urate-induced acute gouty arthritis in rats

[0026] 1. Experimental materials

[0027] 1.1 Experimental drugs: Pulsatilla saponin B4 injection (self-made, hereinafter referred to as "B4 injection"); colchicine, batch number: 171116, Xishuangbanna Banna Pharmaceutical Co., Ltd.

[0028] Above-mentioned B4 injection is prepared by the following method:

[0029] Take the raw material of Pulsatilla saponin B4 in the prescribed amount, accurately weigh it, add an appropriate amount of water for injection, and after the raw material of Pulsatilla saponin B4 is completely dissolved under the action of magnetic stirring, add activated carbon with a solution mass of 0.10% to the solution, and put it in a water bath at 100 ° C. Heat and stir for 15 minutes, dilute to 100ml with water for injection, shake well, filter through a 0.22μm microporous membrane to remove activated carbon, accurately mea...

Embodiment 2

[0046] Example 2 Re-observation of the effect of Pulsatilla saponin B4 on sodium urate-induced acute gouty arthritis in rats

[0047] On the basis of Example 1, the dosage of Pulsatilla saponin B4 was increased, and its effect of improving the joint swelling of acute gouty arthritis in rats induced by sodium urate was investigated again.

[0048] 1. Experimental material: "1." item with embodiment 1

[0049] 2. Experimental method

[0050] 2.1 Preparation of sodium urate (MSU) crystals and suspension: the same as item "2.1" of Example 1.

[0051] 2.2 Group administration and model establishment:

[0052] 2.2.1 Grouping: 50 rats were randomly divided into 5 groups according to body weight, 10 in each group:

[0053] ①model group, ②colchicine group (0.15mg / kg), ③B4 subcutaneous injection group (2.5mg / kg*2), ④B4 intravenous injection group (2.5mg / kg*2), ⑤B4 intramuscular injection Drug high dose group (2.5mg / kg*2).

[0054] 2.2.2 Administration: The model group was injected ...

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PUM

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Abstract

The invention relates to a novel medical application of pulsatilla saponin B4, and particularly provides application of the pulsatilla saponin B4 in preparation of a medicine for treating treatment acute gouty arthritis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new medicine application of Pulsatilla saponin B4. Background technique [0002] Gout is a long-term purine metabolic disorder, a group of diseases caused by increased blood uric acid and tissue damage. Acute gouty arthritis is a characteristic symptom of gout, and it is a characteristic acute inflammatory reaction caused by the deposition of urate crystals in joints (especially ankle and foot joints) and surrounding connective tissue. It often flares up at night, and the patient wakes up with pain and can't sleep through the night. Acute gouty arthritis often recurs, and over time, it can develop into polyarthritis or migratory arthritis. The affected joints are red, swollen, hot, painful, and their activities are limited, which seriously affects the quality of life of patients. In my country, with the continuous improvement of people's living standards, high intake of hi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/192A61K31/216A61K31/405A61K31/63A61K31/12A61K31/196A61K31/365A61K31/415A61K31/444A61K31/573A61K31/661A61P19/06A61P19/02
CPCA61K31/704A61K31/192A61K31/216A61K31/405A61K31/63A61K31/12A61K31/196A61K31/365A61K31/415A61K31/444A61K31/573A61K31/661A61P19/06A61P19/02A61K2300/00A61K45/06A61K31/165Y02A50/30A61K9/0019
Inventor 刘琦
Owner 刘琦
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