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Sustained-release gel material with double-effect drug loading function as well as preparation method and application thereof

A slow-release gel and drug-loading technology, which is applied in the fields of botany equipment and methods, applications, chemicals for biological control, etc., can solve the long-lasting effect period, the coating rate is not high enough, and the slow-release requirements Limitations and other issues, to achieve the effect of accelerating the degradation rate, easy access to raw materials, and improving mechanical properties and strength

Inactive Publication Date: 2020-05-05
虞毅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its shortcomings such as easy water absorption and low strength and modulus after swelling, the slow-release requirements are limited.
However, the preparation process of traditional coating materials is relatively complicated, the coating rate is not high enough, and the duration of efficacy needs to be improved

Method used

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  • Sustained-release gel material with double-effect drug loading function as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The preparation of the biodegradable sustained-release gel film with dual-effect drug-loading function includes:

[0050] Step 1: Weigh 5g of polylactic acid (PLA) and dissolve it in 15mL of chloroform until it is completely dissolved. After standing for 24 hours, the PLA molecular chain is completely stretched, and then add 0.15mL of imidacloprid into the dissolved PLA chloroform solution for use;

[0051] Step 2: Weigh 0.2g of Span 80 and stir at 40°C for 30min to dissolve in 100mL of distilled water to obtain a continuous aqueous phase for use;

[0052] Step 3: slowly pour the organic phase obtained in step 1 into the continuous water phase obtained in step 2, and emulsify at a high speed of 1000r / min for 0.5h to form an O / W emulsion. Add antifoaming agent and stir for 6 hours at 50°C. With the slow volatilization of chloroform, PLA gradually settles to form a suspension of PLA drug-loaded microspheres;

[0053] Step 4: Weigh 1g of gelatin at 40°C and stir at a spee...

Embodiment 2

[0058] The preparation of the biodegradable sustained-release gel film with dual-effect drug-loading function includes:

[0059] Step 1: Weigh 5g of polylactic acid (PLA) and dissolve it in 20mL of chloroform until it is completely dissolved. After standing for 20 hours, the PLA molecular chain is completely stretched, and then add 0.2mL of imidacloprid into the dissolved PLA chloroform solution for use;

[0060] Step 2: Weigh 0.2g of Span 80 and stir at 40°C for 30min to dissolve in 150mL of distilled water to obtain a continuous aqueous phase for use;

[0061] Step 3: slowly pour the organic phase obtained in step 1 into the continuous water phase obtained in step 2, and emulsify at a high speed of 1200r / min for 0.6h to form an O / W emulsion. Add antifoaming agent and stir for 5 hours at 30°C. With the slow volatilization of chloroform, PLA gradually settles to form a suspension of PLA drug-loaded microspheres;

[0062] Step 4: Weigh 1g of gelatin at 50°C and stir at a speed...

Embodiment 3

[0067] The preparation of the biodegradable sustained-release gel film with dual-effect drug-loading function includes:

[0068] Step 1: Weigh 10g of polylactic acid (PLA) and dissolve it in 20mL of chloroform until it is completely dissolved. After standing for 24 hours, the PLA molecular chain is completely stretched, and then add 0.15mL of imidacloprid into the dissolved PLA chloroform solution for use;

[0069] Step 2: Weigh 0.1g of Span 80 and stir at 40°C for 30min to dissolve in 100mL of distilled water to obtain a continuous aqueous phase for use;

[0070] Step 3: slowly pour the organic phase obtained in step 1 into the continuous water phase obtained in step 2, and emulsify at a high speed of 1500r / min for 0.5h to form an O / W emulsion. Add antifoaming agent at 80°C and stir for 10 hours. With the slow volatilization of chloroform, PLA gradually settles to form a suspension of PLA drug-loaded microspheres;

[0071] Step 4: Weigh 1g of gelatin at 20°C and stir at a sp...

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Abstract

The invention discloses a sustained-release gel material with a double-effect drug loading function as well as a preparation method and application thereof. The preparation method comprises the following steps: a drug loading polyester microsphere suspension, a surfactant and a first system are mixed and dispersed to obtain a second system, the second system is frozen and dried, and the sustained-release gel material with the double-effect drug loading function is obtained. The preparation method of the drug loading polyester microsphere suspension comprises the following steps: dissolving polymer polyester and chloroform, standing, adding a first agent to prepare an organic phase, adding an emulsifier and water to prepare a continuous aqueous phase, and adding the organic phase into the continuous aqueous phase to obtain the drug loading polyester microsphere suspension. The preparation of the first system comprises the following steps: respectively adding natural polymer materials into distilled water to prepare at least two mixed solutions, adjusting the pH value to 9-13, adding a second agent, adding a cross-linking agent, carrying out a stirring reaction, and carrying out centrifugal defoaming after the reaction is completed to obtain the first system. The sustained-release material disclosed by the invention realizes double-layer release and can be applied to the fields of agriculture and forestry, medicines and the like.

Description

technical field [0001] The invention relates to the technical field of material preparation, in particular to a slow-release gel material with dual-effect drug loading function, its preparation method and application. Background technique [0002] my country is a large agricultural country, and chemical pesticides are indispensable in the process of agricultural and forestry production and plant growth. However, due to excessive use of pesticides and unscientific application methods, problems such as drug residues, serious drug damage, environmental pollution, and increased production costs have not only reduced the efficiency of pesticides in killing pests and diseases, but also traditional pesticides cannot avoid sun exposure, wind, etc. Objective factors such as blowing and raining cause the decomposition and loss of drugs, so it is easy to cause serious pollution to the environment. In addition, plant growth regulators are also widely used in agricultural and forestry p...

Claims

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Application Information

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IPC IPC(8): A01N25/10A01N25/28A01N51/00A01N43/22A01N33/22A01N47/22A01N43/12A01N43/88A01N37/10A01N43/38A01N57/20A01N43/90A01N57/14A01N57/16A01N47/40A01P7/04A01P7/02A01P21/00C08L67/04C08K5/3445C08J5/18
CPCA01N25/10A01N25/28A01N51/00A01N43/22A01N33/22A01N47/22A01N43/12A01N43/88A01N37/10A01N43/38A01N57/20A01N43/90A01N57/14A01N57/16A01N47/40C08J5/18C08J2367/04C08K5/3445
Inventor 原伟杰虞毅张敏
Owner 虞毅
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