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Supercritical fluid extraction method of high-purity sterol

A technology of supercritical fluid and pure sterol is applied in the field of supercritical fluid extraction technology to separate, purify high-purity sterol, and extract and purify high-purity sterol. To achieve the effect of simple process operation and low production cost

Inactive Publication Date: 2003-06-11
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The above-mentioned various processes are not ideal enough, or consume a large amount of flammable organic solvents, or the product purity is not high, or high temperature easily decomposes sterols

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] With 8.8% sterol content and 6 kg of deodorized soybean oil with an acid value of 117, add 2.5 L of methanol and 160 ml of concentrated flow acid, and stir and reflux for 3 hours at 70°C, add 2.5 L of water to stop the reaction, remove the lower layer, and continue to use The oil phase was washed with hot water until it became neutral, and the oil phase was cooled overnight at 5°C, and centrifuged to obtain 700 g of crude sterols.

[0025] Put the crude sterols into a 1-liter extractor, pump in carbon dioxide, and heat at the same time. When the extraction temperature reaches 35°C and the pressure reaches 18MPa, the cycle starts. The flow rate of carbon dioxide is 20 kg / hour. During the cycle, carbon dioxide and extraction The extract is separated out in the separator through decompression in the separator (the pressure is adjusted to be 5MPa, and the temperature is 45° C.), and the carbon dioxide is recycled. After extracting for 3.5 hours, stop the machine and take out...

example 2

[0027] 8.8% sterol content, 6 kg of deodorized soybean oil with an acid value of 117, add 2.0 L of methanol, 140 ml of concentrated flow acid, and stir and reflux for 4 hours at 70 ° C, add 2.0 L of water to stop the reaction, remove the lower layer, continue to use The oil phase was washed with hot water until it became neutral, and the oil phase was cooled overnight at 10°C, and centrifuged to obtain 650 grams of crude sterols.

[0028] Put the crude sterols into a 1-liter extractor, pump in carbon dioxide, and heat at the same time. When the temperature reaches 60°C and the pressure reaches 30MPa, the cycle starts. The flow rate of carbon dioxide is 20 kg / hour. During the cycle, the carbon dioxide and the extract In the separator, the extract is separated out in the separator through decompression (the pressure is adjusted to be 5MPa, and the temperature is 50° C.), and the carbon dioxide is recycled. After 3 hours of extraction, stop and take out 310 grams of raffinate from...

example 3

[0030] With 8.8% sterol content and 6 kg of deodorized soybean oil with an acid value of 117, add 2.5 L of methanol and 160 ml of concentrated flow acid, and stir and reflux for 3 hours at 70°C, add 2.5 L of water to stop the reaction, remove the lower layer, and continue to use The oil phase was washed with hot water until neutral, and the oil phase was cooled overnight at 5° C., and centrifuged to obtain 710 g of crude sterols.

[0031] Put the crude sterols into a 1-liter extractor, and pump carbon dioxide and 5% ethanol synergist, heat simultaneously, and when the temperature reaches 65°C and the pressure reaches 30MPa, the circulation starts, and the carbon dioxide flow rate is 20 kg / hour. During the circulation process, the carbon dioxide and the extract are decompressed in the separator (the pressure is adjusted to 5MPa, and the temperature is 40°C), and the extract is separated out in the separator, and the carbon dioxide is recycled. After 2.5 hours of extraction, the ...

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Abstract

The preparation method of refined high-purity sterol by utilizing supercritical fluid is characterized by using by-product obtained in the course of processing vegetable oil as raw material, according to that sterol and other components are different in soubility in supercritical fluid making purification and refinement, and its optimum extraction agent is CO2, extraction pressure is 15-35 MPa, extraction temp. is 32-75 deg.C, separation temp. is 40-60 deg.C, separation pressure is 4-6MPa, and in the course of extraction the synergist alcohol or ketone can be added. The obtained sterol is high in purity and yield.

Description

Technical field: [0001] The invention relates to a method for extracting and purifying high-purity sterols from vegetable oil refining and processing by-products, in particular to a process for separating and refining high-purity sterols using supercritical fluid extraction technology, and belongs to the field of deep processing and comprehensive utilization of agricultural by-products. Background technique: [0002] Phytosterol is a natural physiologically active substance that is very beneficial to the human body. It is known as the "key of life". In addition, using phytosterols as raw materials, almost all steroidal drugs can be synthesized, which is a $4 billion industry worldwide. Therefore, the separation and purification of phytosterols has been highly valued. The sterol resources with production significance mainly include vegetable oil refining by-products, sugar by-products and papermaking waste liquid. Among them, vegetable oil refining by-products are the main s...

Claims

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Application Information

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IPC IPC(8): B01D3/34C07J9/00C07J75/00
CPCY02P20/54
Inventor 赵亚平王大璞
Owner SHANGHAI JIAO TONG UNIV
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