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Biologically functionalized surface-modified polyether-ether-ketone material as well as preparation method and application thereof

A biological functionalization, polyetheretherketone technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve problems such as single promotion of osseointegration or inhibition of inflammatory response, failure of host osseointegration, lack of biological activity, etc. Achieve good multiple biological properties, improve lack of biological activity, and good reproducibility

Inactive Publication Date: 2020-05-08
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PEEK is biologically inert and hydrophobic, lacks biological activity, and cannot be well osseointegrated with the host bone after implantation, which greatly limits its wide clinical application.
[0005] Therefore, the surface modification of polyether ether ketone biomaterials should have the ability to promote polyetheretherketone osseointegration and inhibit inflammation at the same time, but most of the functional materials currently used in orthopedics have a single ability to promote osseointegration or inhibit inflammation.

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  • Biologically functionalized surface-modified polyether-ether-ketone material as well as preparation method and application thereof
  • Biologically functionalized surface-modified polyether-ether-ketone material as well as preparation method and application thereof
  • Biologically functionalized surface-modified polyether-ether-ketone material as well as preparation method and application thereof

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Embodiment Construction

[0028] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the teachings of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0029] The invention provides a method for preparing a surface-modified polyether ether ketone material, which specifically includes:

[0030] PEEK (diameter 10mm, thickness 2mm; Jiangsu Junhua Special Engineering Plastic Products Co., Ltd.) was soaked in different acids for 0.5h for acidification, then soaked in deionized water for 24h to remove excess acid, and then rinsed with deionized water Ultrasonic cleaning was perform...

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Abstract

According to the invention, a strong acid acidification method is combined to carry out biological functional modification on an orthopaedic biological material PEEK tablet, so that the orthopaedic biological material PEEK tablet is endowed with biological activity of inhibiting secretion of inflammatory factors while promoting osteogenic differentiation and bone mineralization of bone marrow mesenchymal stem cells. The PEEK surface modification method is simple and low in cost, and a prepared PEEK implant has multiple biological functions and is expected to promote osseointegration in a PEEKorthopaedic implant and reduce loosening-related complications caused by early excessive inflammatory response after the PEEK sheet is implanted into a body.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, and in particular relates to a biofunctionalized surface-modified polyether ether ketone material and a preparation method and application thereof. Background technique [0002] A perfect orthopedic implant should avoid complications after implant placement. Goodman (GoodmanSB, Biomaterials 2013,34(13):3174-3183) proposed that orthopedic biocoating implants in the future focus on improving osseointegration and reducing chronic inflammatory responses. Han (Han, Biomaterials, 2010. 31(13): p.3465-70.) believes that an excellent orthopedic prosthesis should not only have the potential to promote bone tissue growth, but also have good biocompatibility. In conclusion, the functional modification of the surface of orthopedic implants should not only inhibit the inflammatory response around the implant, but also improve the osseointegration of the implant. [0003] At present, mos...

Claims

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Application Information

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IPC IPC(8): C08J7/14A61L27/18A61L27/54A61L27/50C08L61/16
CPCC08J7/14A61L27/18A61L27/54A61L27/50C08J2361/16A61L2430/02A61L2300/216A61L2300/41A61L2300/412C08L61/16
Inventor 聂彬恩岳冰霍市城王友
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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