Application of plant polysaccharide in preparing medicines for intestinal type-related hyperuricemia

A technology of hyperuricemia and polysaccharide is applied in the application field of hyperuricemia drugs to achieve good therapeutic effect

Pending Publication Date: 2020-05-12
SHENZHEN HUADA GENE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the effect of psyllium husk on hyperuricemia

Method used

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  • Application of plant polysaccharide in preparing medicines for intestinal type-related hyperuricemia
  • Application of plant polysaccharide in preparing medicines for intestinal type-related hyperuricemia
  • Application of plant polysaccharide in preparing medicines for intestinal type-related hyperuricemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] In this case, the intervention effect of inulin on people with different intestinal types was studied, the details are as follows:

[0062] 1. Sample Collection

[0063] In this trial, a 5-month inulin intervention program was carried out. A total of 25 Chinese cases were enrolled, including 14 males and 11 females. Most of the subjects in this trial were patients with hyperuricemia. Hyperuricemia patients The standard for judging hyperuricemia patients is fasting blood uric acid value: male > 420 μmol / L, female > 360 μmol / L. All the subjects in this trial were without gout. At the same time, the following types of subjects need to be excluded: 1) pregnant women and nursing mothers; 2) taking / injecting antibiotics, steroid hormones, uric acid-lowering drugs, Probiotics, prebiotics, etc.; 3) Patients with severe gastrointestinal diseases, including colorectal cancer, IBS, IBD, chronic or acute diarrhea, long-term constipation, etc.; 4) Patients receiving gastrointestina...

Embodiment 2

[0085] In order to further verify the results of Example 1, this experiment expanded the sample size, recruited another batch of 60 patients with hyperuricemia, and carried out a 35-day inulin intervention experiment to determine the intervention effect of different intestinal types.

[0086] The inclusion criteria of the subjects are: hyperuricemia population, fasting blood uric acid value: male>420μmol / L, female>360μmol / L.

[0087] Similarly, subjects in the following situations are excluded:

[0088] 1) Pregnant women and nursing mothers;

[0089] 2) Taking / injecting antibiotics, steroid hormones, uric acid-lowering drugs, probiotics, prebiotics, etc. in the past 3 months;

[0090] 3) Patients with severe gastrointestinal diseases, including colorectal cancer, IBS, IBD, chronic or acute diarrhea, long-term constipation, etc.;

[0091] 4) Receive patients with gastrointestinal surgery and abdominal surgery within one year, such as cholecystectomy;

[0092] 5) Patients wit...

Embodiment 3

[0112] This case studies the intervention effect of psyllium husk on people with different intestinal types, the details are as follows:

[0113] 1. Sample Collection

[0114] In this study, a group of 28 patients with hyperuricemia were recruited, and a 35-day intervention experiment of psyllium husk was carried out to determine the intervention effect of psyllium husk on different intestinal types.

[0115] The subjects of this test were all patients with hyperuricemia, and the judgment standard for patients with hyperuricemia was that the fasting blood uric acid value of patients with hyperuricemia was >420 μmol / L for males and >360 μmol / L for females. All the subjects in this trial were without gout. At the same time, the following types of subjects need to be excluded: 1) pregnant women and nursing mothers; 2) taking / injecting antibiotics, steroid hormones, uric acid-lowering drugs, Probiotics, prebiotics, etc.; 3) Patients with severe gastrointestinal diseases, includin...

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Abstract

The invention discloses an application of plant polysaccharide in preparing medicine, food, health care product or food additive for intestinal type-related hyperuricemia, wherein the plant polysaccharide is inulin and / or psyllium seed husk, and the intestinal type-related hyperuricemia is prevotella intestinal type hyperuricemia and / or bacteroides intestinal type hyperuricemia. The invention provides the new application for two vegetable polysaccharides comprising inulin and psyllium seed husks, namely, the application in treating or preventing intestinal type-related hyperuricemia, in particular to prevotella intestinal type hyperuricemia and / or bacteroides intestinal type hyperuricemia. Discovery of the new application has a good guiding effect on implementation of individualized diagnosis and treatment, and has important significance on clinical application and deep research of vegetable polysaccharides.

Description

technical field [0001] The present application relates to the field of enterotype-associated hyperuricemia treatment or preventive medicine, in particular to the application of plant polysaccharides as preparation of enterotype-associated hyperuricemia medicine. Background technique [0002] Hyperuricemia (HUA) refers to the state of normal purine diet, the fasting blood uric acid level is higher than 420 μmol / L for men and higher than 360 μmol / L for women twice on different days, which is called hyperuricemia and belongs to metabolic diseases . [0003] In 2011, the concept of enterotypes was first proposed by Arumugam et al. in the journal Nature (Arumugam, Manimozhiyan, et al."Enterotypes of the human gut microbiome."nature473.7346(2011):174-180) , the study found that the human intestinal microbiome can be divided into three stable types, which are not displayed by age, gender, weight and region, and have high stability, similar to blood types, so they are called "gut t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/125A23L33/10A61K31/733A61K36/68A61P19/06A61K131/00
CPCA23L33/125A23L33/10A61K31/733A61K36/68A61P19/06A23V2002/00A23V2200/30A23V2250/5062
Inventor 李忠霞陈沛珊蔡雪梅蔡锴晔李晓平钟焕姿
Owner SHENZHEN HUADA GENE INST
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