Preparation method of fluorinated polyhexamethylene biguanide

A technology of fluorinated polyhexamethylene biguanide and polyhexamethylene biguanide hydrochloride, which is applied in the field of preparation of fluorinated polyhexamethylene biguanide, can solve the problems of harming the health of the whole body, fluorine-resistant strains, and excessive fluoride intake and other issues to achieve the effect of avoiding side effects, reducing side effects, and low cost
CN111138660AActive Publication Date: 2020-05-12ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2020-05-12

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Abstract

The invention provides a method for preparing fluorinated polyhexamethylene biguanide. The method comprises the following steps: adding water into polyhexamethylene biguanide hydrochloride powder, dissolving, precipitating, removing the precipitate, dialyzing, centrifuging and drying to obtain the fluorinated polyhexamethylene biguanide. The method is mild in reaction condition, simple in preparation method and suitable for large-scale industrial production and application. The product fluorinated polyhexamethylene biguanide can give play to the synergistic effect of polyhexamethylene biguanide and sodium fluoride, effectively reduces the side effects when polyhexamethylene biguanide and sodium fluoride are independently used or used in a compatible manner, and can be applied to the fieldsof oral gargle, toothpaste, enamel remineralization liquids, fluorine foams and fluorine gels.
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Description

technical field

[0001] The invention belongs to the preparation technology of functional guanidine-based polymer functional materials, and relates to a preparation method of fluorinated polyhexamethylene biguanide. Background technique

[0002] With the advancement and development of science and technology, people's understanding of microorganisms is getting deeper and deeper. In order to avoid the threat of pathogenic microorganisms to human health, cationic antibacterial agents have gradually appeared in people's daily life, and polyhexamethylene Biguanides are one of them. The antibacterial performance of polyhexamethylene biguanide mainly depends on the guanidine group it contains, which has high biological activity and safety.

[0003] Fluoride is often found in various anti-caries products due to its unique antibacterial and remineralizing capabilities. Studies have found that the application of sodium fluoride can better inhibit the occurrence of demineralization ca...

Claims

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