Material for preparing hydrophilic micro-fluidic chip, and micro-fluidic chip

A microfluidic chip and hydrophilic technology, which is applied in the direction of laboratory containers, laboratory utensils, chemical instruments and methods, etc., can solve the problems of easy peeling off of the coating, rapid processing regression, and limited application, etc., to achieve Reduce time and process costs, reduce non-specific adsorption, and reduce the effect of non-specific adsorption

Inactive Publication Date: 2020-05-15
重庆创芯生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, plasma modification and UV irradiation modification have high equipment cost, large energy consumption, complicated process, and the modification process may damage the surface of the substrate, and the treatment retreats quickly, which is a great disadvantage. limit its use in industrial production
The coating prepared by the nano-coating modification method has good uniformity and stability, but the coating requires a lot of space when it is dried, and the microfluidic chip needs to be embedded in the surface of the microfluidic chip in the later stage, so the coating is easy. The problem of shedding greatly limits the application of this method

Method used

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  • Material for preparing hydrophilic micro-fluidic chip, and micro-fluidic chip
  • Material for preparing hydrophilic micro-fluidic chip, and micro-fluidic chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 100 parts of dry rubber, 1 part of hydrophilic additive, 2 parts of color masterbatch, mix them evenly, pour them into the injection molding machine, set the injection molding parameters as follows: nozzle temperature 230°C, injection speed 100mm / s, mold temperature 70°C, keep The pressing pressure is 65MPa, the holding time is 2s, and the microfluidic chip mold is used together to prepare a hydrophilic microfluidic chip.

[0029] The sizing material used in this embodiment is polymethyl methacrylate (PMMA); the hydrophilic auxiliary agent is polyvinyl alcohol.

Embodiment 2

[0031] Take 100 parts of dry rubber, 0.1 part of hydrophilic additive, 1 part of color masterbatch, mix well, pour into the injection molding machine, set the injection molding parameters as follows: nozzle temperature 230°C, injection speed 100mm / s, mold temperature 70°C, keep The pressing pressure is 65MPa, the holding time is 2s, and the microfluidic chip mold is used together to prepare a hydrophilic microfluidic chip.

[0032] The sizing material used in this embodiment is polymethyl methacrylate (PMMA); the hydrophilic auxiliary agent is polyacrylic acid.

Embodiment 3

[0034] Take 100 parts of dry rubber, 5 parts of hydrophilic additives, and 5 parts of color masterbatch, mix them evenly, pour them into the injection molding machine, set the injection molding parameters as follows: nozzle temperature 230°C, injection speed 100mm / s, mold temperature 70°C, keep The pressing pressure is 65MPa, the holding time is 2s, and the microfluidic chip mold is used together to prepare a hydrophilic microfluidic chip.

[0035] The rubber material used in this embodiment is polydimethylsiloxane (PDMS); the hydrophilic auxiliary agent is polyvinylpyrrolidone.

[0036] The present invention also prepares hydrophilic microfluidic chips prepared from other raw materials, and the specific raw material ratios are shown in Table 1.

[0037] Table 1 is used to prepare the raw material proportion (parts by weight) of hydrophilic microfluidic chip

[0038] Sample / raw material Gum Hydrophilic additive masterbatch sample 1 100 0.5 2 sampl...

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Abstract

The invention discloses a material for preparing a hydrophilic micro-fluidic chip, and the micro-fluidic chip. The material is prepared from, by weight, 100 parts of a sizing material, 0.1 to 5 partsof a hydrophilic auxiliary agent and 1 to 5 parts of a color master batch. The micro-fluidic chip is made of the material through one-step processing of injection molding. The material for preparing the hydrophilic micro-fluidic chip is simple in formula, the hydrophilic auxiliary agent cannot be denatured due to the influence of injection molding conditions, and the characteristics of color, character and the like of the chip cannot be influenced. Hydrophilic modification treatment does not need to be additionally carried out on the surface of the chip, the prepared chip has hydrophilicity immediately, the non-specific adsorption of the chip is effectively reduced, and the production time and the process cost of the chip are greatly saved.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a material for preparing a hydrophilic microfluidic chip and a microfluidic chip prepared from the material. Background technique [0002] Microfluidics refers to the technology that integrates the basic operation units such as sample preparation, reaction, separation, and detection in the biological, chemical, and medical analysis processes into a micron-scale chip to automatically complete the entire analysis process. Microfluidic chip is the main platform and device for the realization of microfluidic technology. [0003] There are many materials currently used to prepare microfluidic chips, including inorganic materials, organic materials, hydrogels, and paper. Polymer materials have become the leading material for microfluidic chip processing in recent years. It has a wide variety, low price, good insulation, can be applied with a high electric field to achieve ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B29C45/00
CPCB01L3/502707B01L2200/027B01L2200/10B01L2300/161B29C45/00
Inventor 于梦露杨杰赵朝辉钟越兰诗玉
Owner 重庆创芯生物科技有限公司
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